CleftGeneDB-Search

Gene: DLX2

Basic information

Tag	Content
Uniprot ID	K7AA60; A0A2J8PQW6; H2QIZ5;
Entrez ID	459741
Genbank protein ID	JAA29320.1; JAA14701.1; JAA34979.1;
Genbank nucleotide ID	XM_016950040.1
Ensembl protein ID	ENSPTRP00000021601
Ensembl nucleotide ID	ENSPTRG00000012640
Gene name	Distal-less homeobox 2
Gene symbol	DLX2
Organism	Pan troglodytes
NCBI taxa ID	9598
Cleft type
Developmental stage
Data sources	Homology search
Reference
Functional description
Sequence	MTGVFDSLVA DMHSTQIAAS STYHQHQQPP SGGGAGPGGN NSSSSSLHKP QESPTLPVST 60 ATDSSYYTNQ QHPAGGGGGG GSPYAHMGSY QYQASGLNNV PYSAKSSYDL GYTAAYTSYA 120 PYGTSSSPAN NEPEKEDLEP EIRIVNGKPK KVRKPRTIYS SFQLAALQRR FQKTQYLALP 180 ERAELAASLG LTQTQVKIWF QNRRSKFKKM WKSGEIPSEQ HPGASASPPC ASPPVSAPAS 240 WDFGAPQRMA GGGGPGSGGS GAGSSGSSPS SAASAFLGNY PWYHQTSGSA SHLQATAPLL 300 HPTQTPQPHH HHHHHGGGGA PVSAGTIF 328

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

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Relation	Gene symbol	Entrez ID	UniProt ID	Cleft type	Species	Evidence	Details
1:1 ortholog	Dlx2	13392	P40764	CPO	Mus musculus	Publication	More>>
1:1 ortholog	DLX2	528490	E1BCF7		Bos taurus	Prediction	More>>
1:1 ortholog	DLX2	100856541	E2R5E5		Canis lupus familiaris	Prediction	More>>
1:1 ortholog	DLX2	102188447	A0A452FZW1		Capra hircus	Prediction	More>>
1:1 ortholog	DLX2	1746	Q07687		Homo sapiens	Prediction	More>>
1:1 ortholog	DLX2	459741	K7AA60		Pan troglodytes	Prediction	More>>
1:1 ortholog	DLX2	100523029	F1S082		Sus scrofa	Prediction	More>>
1:1 ortholog	Dlx2	296499	G3V668		Rattus norvegicus	Prediction	More>>
1:1 ortholog	dlx2a	30574	F6NKE2		Danio rerio	Prediction	More>>

Showing 1 to 9 of 9 entries

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Gene ontology

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GO ID	GO Term
GO:0000122	negative regulation of transcription by RNA polymerase II
GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003682	chromatin binding
GO:0003700	DNA-binding transcription factor activity
GO:0003727	single-stranded RNA binding
GO:0005634	nucleus
GO:0006357	regulation of transcription by RNA polymerase II
GO:0009954	proximal/distal pattern formation
GO:0021544	subpallium development
GO:0021766	hippocampus development
GO:0021772	olfactory bulb development
GO:0021882	regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment
GO:0021893	cerebral cortex GABAergic interneuron fate commitment
GO:0030154	cell differentiation
GO:0042475	odontogenesis of dentin-containing tooth
GO:0043565	sequence-specific DNA binding
GO:0045746	negative regulation of Notch signaling pathway
GO:0045944	positive regulation of transcription by RNA polymerase II
GO:0046533	negative regulation of photoreceptor cell differentiation