| Tag | Content |
|---|---|
| Uniprot ID | P40764 |
| Entrez ID | 13392 |
| Genbank protein ID | AAA40412.1; AAA18487.1; AAB40901.1; |
| Genbank nucleotide ID | NM_010054.2 |
| Ensembl protein ID | ENSMUSP00000024159 |
| Ensembl nucleotide ID | ENSMUSG00000023391 |
| Gene name | Homeobox protein DLX-2 |
| Gene symbol | Dlx2 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 9187081; 12902388; 7590232; 23246068; 22972697; |
| Functional description | Acts as a transcriptional activator (PubMed:21875655). Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina (PubMed:21875655). Likely to play a regulatory role in the development of the ventral forebrain (PubMed:1678612). May play a role in craniofacial patterning and morphogenesis (PubMed:1678612). |
| Sequence | MTGVFDSLVA DMHSTQITAS STYHQHQQPP SGAGAGPGGN SNSSSSNSSL HKPQESPTLP 60 VSTATDSSYY TNQQHPAGGG GGGASPYAHM GSYQYHASGL NNVSYSAKSS YDLGYTAAYT 120 SYAPYGTSSS PVNNEPDKED LEPEIRIVNG KPKKVRKPRT IYSSFQLAAL QRRFQKTQYL 180 ALPERAELAA SLGLTQTQVK IWFQNRRSKF KKMWKSGEIP TEQHPGASAS PPCASPPVSA 240 PASWDFGAPQ RMAGGGPGSG GGGAGSSGSS PSSAASAFLG NYPWYHQASG SASHLQATAP 300 LLHPSQTPQA HHHHHHHHHA GGGAPVSAGT IF 332 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | DLX2 | 528490 | E1BCF7 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | DLX2 | 100856541 | E2R5E5 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | DLX2 | 102188447 | A0A452FZW1 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | DLX2 | 1746 | Q07687 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Dlx2 | 13392 | P40764 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | DLX2 | 459741 | K7AA60 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | DLX2 | 100523029 | F1S082 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Dlx2 | 296499 | G3V668 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | dlx2a | 30574 | F6NKE2 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IDA |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding | IBA |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IDA |
| GO:0003677 | DNA binding | IDA |
| GO:0003682 | chromatin binding | IDA |
| GO:0003700 | DNA-binding transcription factor activity | IBA |
| GO:0003727 | single-stranded RNA binding | IPI |
| GO:0005515 | protein binding | IPI |
| GO:0043565 | sequence-specific DNA binding | IBA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IGI |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IBA |
| GO:0006357 | regulation of transcription by RNA polymerase II | IBA |
| GO:0006357 | regulation of transcription by RNA polymerase II | IGI |
| GO:0009954 | proximal/distal pattern formation | IGI |
| GO:0009954 | proximal/distal pattern formation | IMP |
| GO:0021544 | subpallium development | IGI |
| GO:0021766 | hippocampus development | IGI |
| GO:0021772 | olfactory bulb development | IMP |
| GO:0021879 | forebrain neuron differentiation | IGI |
| GO:0021882 | regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment | IGI |
| GO:0021892 | cerebral cortex GABAergic interneuron differentiation | IGI |
| GO:0021893 | cerebral cortex GABAergic interneuron fate commitment | IGI |
| GO:0030154 | cell differentiation | IMP |
| GO:0030154 | cell differentiation | IBA |
| GO:0042475 | odontogenesis of dentin-containing tooth | IGI |
| GO:0045597 | positive regulation of cell differentiation | IMP |
| GO:0045746 | negative regulation of Notch signaling pathway | IGI |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IDA |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IGI |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IBA |
| GO:0046533 | negative regulation of photoreceptor cell differentiation | IMP |
| GO:0048701 | embryonic cranial skeleton morphogenesis | IMP |
| GO:0048706 | embryonic skeletal system development | IGI |
| GO:0048706 | embryonic skeletal system development | IMP |
| GO:0048715 | negative regulation of oligodendrocyte differentiation | IGI |
| GO:0048755 | branching morphogenesis of a nerve | IMP |
| GO:0051216 | cartilage development | IMP |
| GO:1902871 | positive regulation of amacrine cell differentiation | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005634 | nucleus | IDA |
| GO:0005634 | nucleus | IBA |
| Reactome ID | Reactome Term | Evidence |
|---|