| Tag | Content |
|---|---|
| Uniprot ID | F1S082 |
| Entrez ID | 100523029 |
| Genbank protein ID | HCZ75566.1 |
| Genbank nucleotide ID | XM_003133477.3 |
| Ensembl protein ID | ENSSSCP00000016906 |
| Ensembl nucleotide ID | ENSSSCG00000015954 |
| Gene name | Distal-less homeobox 2 |
| Gene symbol | DLX2 |
| Organism | Sus scrofa |
| NCBI taxa ID | 9823 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MTGVFDSLVA DMHSTQITAS STYHQHQQPP SGGGAGPGGS NGSSLHKPQE SPTLPVSTAT 60 DSSYYTNQQH PAGGGGGGGG SPYAHMGSYQ YHASGLNNVP YSAKSGYDLG YTAAYTSYAP 120 YGTSSSPANN EPEKEDLEPE IRIVNGKPKK VRKPRTIYSS FQLAALQRRF QKTQYLALPE 180 RAELAASLGL TQTQVKIWFQ NRRSKFKKMW KSGEIPSEQH PGASASPPCA SPPASAPASW 240 DFGAPQRMGG GGGPGSGGSG AGSSGSSPSS AASAFLGNYP WYHQASSSAT HLQAAAPLLH 300 PTQTPQPHHH HHHHHGGGGA PVSAGTIF 328 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | DLX2 | 528490 | E1BCF7 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | DLX2 | 100856541 | E2R5E5 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | DLX2 | 102188447 | A0A452FZW1 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | DLX2 | 1746 | Q07687 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Dlx2 | 13392 | P40764 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | DLX2 | 459741 | K7AA60 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | DLX2 | 100523029 | F1S082 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Dlx2 | 296499 | G3V668 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | dlx2a | 30574 | F6NKE2 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005634 | nucleus |
| GO:0003682 | chromatin binding |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO:0003700 | DNA-binding transcription factor activity |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0043565 | sequence-specific DNA binding |
| GO:0003727 | single-stranded RNA binding |
| GO:0048755 | branching morphogenesis of a nerve |
| GO:0051216 | cartilage development |
| GO:0030154 | cell differentiation |
| GO:0021893 | cerebral cortex GABAergic interneuron fate commitment |
| GO:0048701 | embryonic cranial skeleton morphogenesis |
| GO:0021766 | hippocampus development |
| GO:0045746 | negative regulation of Notch signaling pathway |
| GO:0048715 | negative regulation of oligodendrocyte differentiation |
| GO:0046533 | negative regulation of photoreceptor cell differentiation |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0042475 | odontogenesis of dentin-containing tooth |
| GO:0021772 | olfactory bulb development |
| GO:1902871 | positive regulation of amacrine cell differentiation |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0009954 | proximal/distal pattern formation |
| GO:0006357 | regulation of transcription by RNA polymerase II |
| GO:0021882 | regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment |
| GO:0021544 | subpallium development |