Gene: PHC2

Basic information

Tag Content
Uniprot ID E1BFG7
Entrez ID 537511
Genbank protein ID
Genbank nucleotide ID NM_001192908.1
Ensembl protein ID ENSBTAP00000006041
Ensembl nucleotide ID ENSBTAG00000004603
Gene name Polyhomeotic homolog 2
Gene symbol PHC2
Organism Bos taurus
NCBI taxa ID 9913
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MEDELPVPHT PSSTSVTSSA SGSSSSSSSS GGGSGRPTGP HISVYSGIPD RQTVQVIQQA 60
LHRQPSTAAQ YLQQMYAAQQ QHLMLQTAAL QQQHLSSAQL QSLAAVQQAS LVANRQGSTS 120
GSSVSAQAPT QSSSINLAAS PAAAQLINRA QSVNSAAASG ITQQAVLLGN TSSPALTASQ 180
AQMYLRAQML IFTPTATVAT VQPELGTGSP ARPPTPAQVQ NLTLRSQQTP AAAASGPTPT 240
QPVLTSLALK PTPGGSQPLP TPSQGRNTAQ GSPAGAKSGT TDSVTEPLKR GDSNGSVPGS 300
LEGRAGLSRM VPTVATHPLI APAYAQLQPH QLLSQPSSKH LQPQFVMQQQ QPSQQQQPPQ 360
PSRPALQAPS HPQLASVPPS LALQPSPEAH AMPLGPVPST LPLQCPTANL HKPGSSQQCP 420
PPTPDTGAHN GYPEGLAHTP QRRFQHASAV ILQLQPASPP QQCTPDDWKE VVPGEKSGSE 480
TRSGPSPHQQ AIVTAMPGGL TVPKSPNIQQ SPAHETGQGI VHALTDLSSP GMTSGNGNSA 540
SSITGTAPQN GENKPPQAIV KPQILTHVIE GFVIQEGAEP FPVGRSSLLV GNLKKKYAQG 600
FLPEKLPQQD HTTTTDSEME EPYLQESKEE GTPLKLKCEL CGRVDFAYKF KRSKRFCSMA 660
CAKRYNVGCT KRVGLFHSDR SKLQKAGATT HNRRRASKAS LPTLTKDTKK QPTGTVPLSV 720
TAALQLTHSQ EDSSRCSDNS SYEEPLSPIS ASSSTSRRRQ GPRDLELPDV HMRDLVGMGH 780
HFLPSEPTKW NVDDVYEFIR SLPGCQEIAE EFRAQEIDGQ ALLLLKEDHL MSAMNIKLGP 840
ALKIYARISM LKDS 854

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologPHC2537511E1BFG7Bos taurusPredictionMore>>
1:1 orthologPHC2487297J9P8A4Canis lupus familiarisPredictionMore>>
1:1 orthologPHC2A0A452F0Q9Capra hircusPredictionMore>>
1:1 orthologPHC21912Q8IXK0Homo sapiensPredictionMore>>
1:1 orthologPhc254383Q9QWH1CPOMus musculusPublicationMore>>
1:1 orthologPHC2456729H2PYL7Pan troglodytesPredictionMore>>
1:1 orthologPHC2I3LIR0Sus scrofaPredictionMore>>
1:1 orthologPHC2100351541G1T576Oryctolagus cuniculusPredictionMore>>
1:1 orthologPhc2313038D4A0M3Rattus norvegicusPredictionMore>>
1:1 orthologphc2b394177F6P2R0Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0000792 heterochromatin
GO:0005654 nucleoplasm
GO:0035102 PRC1 complex
GO:0042802 identical protein binding
GO:0008270 zinc ion binding
GO:0007283 spermatogenesis

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0479 Metal-binding
KW-1185 Reference proteome
KW-0862 Zinc
KW-0863 Zinc-finger

Interpro

InterPro ID InterPro Term
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR012313 Znf_FCS
IPR038603 Znf_FCS_sf

PROSITE

PROSITE ID PROSITE Term
PS50105 SAM_DOMAIN
PS51024 ZF_FCS

Pfam

Pfam ID Pfam Term
PF00536 SAM_1