Gene: phc2b

Basic information

Tag Content
Uniprot ID F6P2R0
Entrez ID 394177
Genbank protein ID
Genbank nucleotide ID NM_201202.3
Ensembl protein ID ENSDARP00000018055
Ensembl nucleotide ID ENSDARG00000013224
Gene name Polyhomeotic homolog 2b (Drosophila)
Gene symbol phc2b
Organism Danio rerio
NCBI taxa ID 7955
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MGLTTGPNGA RAAPQKSLRR VWQRGSRGSK VKHRGGTMEG EQSTPAASAS STTGTSTSTT 60
NSTGTTSAST ASTASSTSSS TSSARQAVPQ ISVYSGIPDR QTVQVIQQAL NRQPSTAAQY 120
LQQMYAAQQQ HLMLQTAALQ QQHLSTAQLQ SLAAVQQASL AAGRQSSNQN GTSSTQSGSS 180
QTTINLTTSP AAAQLISRAQ SVNSAPSGIS QQAVLLGNAS SSTLTASQAQ MYLRAQMAQQ 240
SNLVHVARSL GRAVPLSSQL ILAPTATVTA LQSDTNTTNN TQSASAQVQN LALRNHQGVS 300
STPQATGLQA LSLKQTPVSI QPTPLIKTPS QSTGAGKNNL NAASSDGVKK AEEGQTEMKA 360
VNMSRNVSSS HPLIAPAYAQ IQPQALIKQQ PQQFVIQPQA TPTSRSQPQL LQTASIQPHQ 420
QTASLGIPSS AQTSTVTGII PVLPKPALHN QGSAQTQQAT IFHSTVSHHA HTALAHAKAQ 480
PVQLTAINLQ IQPAQNQASR LAQDDKEKPT SLVLREICPP VQIHPSTTTQ GTDPPEQSKA 540
DTVNATSQTQ GSVETAREPT GAQLTSSMTS AVSSEPPPAA VMGNTTQNGE NKPPQAIVKP 600
HVLTHVIEGF VIQEGAEPFP VERPPVAAES PKKPDTQLPS DPEKTASSNS LSATNSDTEE 660
AGQQDTRVEE ETEKPKLTCE LCGWVDFAHK FKRSKRFCSM VCAKRYSVSC TKRVGLFRPD 720
RTKSTNQINQ WRRRRSHSPR GREAKKQRLS VSQQSQGESI SSPLQSQPSQ GESSPCSDIS 780
SYEEATSPLS AASSGPVVSQ GVVAANEPEE LPLLSQHFLP CDPTKWNVQE VFEFIRSLPG 840
CQEIADEFRA QEIDGQALLL LKEDHLMSAM NIKLGPALKI FARINMLKDS

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologPHC2537511E1BFG7Bos taurusPredictionMore>>
1:1 orthologPHC2487297J9P8A4Canis lupus familiarisPredictionMore>>
1:1 orthologPHC2A0A452F0Q9Capra hircusPredictionMore>>
1:1 orthologPHC21912Q8IXK0Homo sapiensPredictionMore>>
1:1 orthologPhc254383Q9QWH1CPOMus musculusPublicationMore>>
1:1 orthologPHC2456729H2PYL7Pan troglodytesPredictionMore>>
1:1 orthologPHC2I3LIR0Sus scrofaPredictionMore>>
1:1 orthologPHC2100351541G1T576Oryctolagus cuniculusPredictionMore>>
1:1 orthologPhc2313038D4A0M3Rattus norvegicusPredictionMore>>
1:1 orthologphc2b394177F6P2R0Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005634 nucleus
GO:0035102 PRC1 complex
GO:0003682 chromatin binding
GO:0003677 DNA binding
GO:0042393 histone binding
GO:0008270 zinc ion binding
GO:0045892 negative regulation of transcription, DNA-templated

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0238 DNA-binding
KW-0479 Metal-binding
KW-0539 Nucleus
KW-1267 Proteomics identification
KW-1185 Reference proteome
KW-0862 Zinc
KW-0863 Zinc-finger

Interpro

InterPro ID InterPro Term
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR012313 Znf_FCS
IPR038603 Znf_FCS_sf

PROSITE

PROSITE ID PROSITE Term
PS50105 SAM_DOMAIN
PS51024 ZF_FCS

Pfam

Pfam ID Pfam Term
PF00536 SAM_1