Gene: PHC2

Basic information

Tag Content
Uniprot ID J9P8A4
Entrez ID 487297
Genbank protein ID
Genbank nucleotide ID XM_003433835.3
Ensembl protein ID ENSCAFP00000041972
Ensembl nucleotide ID ENSCAFG00000010340
Gene name Polyhomeotic homolog 2
Gene symbol PHC2
Organism Canis lupus familiaris
NCBI taxa ID 9615
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MENELPVPHT SSSASVASSA SSGCNSGSSG GSGRPTGPQI SVYSGIPDRQ TVQVIQQALH 60
RQPSTAAQYL QQMYAAQQQH LMLQTAALQQ QHLSSAQLQS LAAVQQASLV ANRQGSTSSS 120
NVSAQAPAPS SSINLAASPA AAQLINRAQS VNSATASGIA QQAVLLGNTS SPALTASQAQ 180
MYLRAQMLIF TPTATVATVQ PELGTGSPAR PPTPAQVQNL TLRTQQTPTA AASGPSPTQP 240
VLPSLALKPT PSGSQPLPTP SQGRNTAQGS PAGAKPGITD SVMEPLKKGD GNSSVPGSME 300
GRAGLSRMVP AVATHPLVAP AYAQLQPHQL LSQPPSKHLQ PQFVLQQQPQ QPAPPPPPPP 360
LPQQSRPALQ AQSHPQLASV PPSLTLQPSP EAHAMPLGPV TPALPLQCPT ANLNKAGSTQ 420
QCHPPTPDAG PHNGYPEGLA HTPQRRFQHA SAVILQLQPA SPVPQECNMD DWKEAVPGEK 480
SVPETRSGPS PHQQAIITAV PGGLPVPKSP NIQQSPAHET GQGIVHALTD LSSPGMTSGN 540
GNSASSITGT APQNGENKPP QAIVKPQILT HVIEGFVIQE GAEPFPVGRS SLLVGNLKKK 600
YAQGFLPEKL PQQDHTTTTD SEMEEPYLQE SKEEGIPLKL KCELCGRVDF AYKFKRSKRF 660
CSMACAKRYN VGCTKRVGLF YPDESKLQMA GITTHNRRRA SKASLPTLTK DTKKQPTGIM 720
PLSVTAALQL THSQEDSSRC SDNSSYEEPL SPISASSSTS RRRQGQRDLE FPDMHMRDLM 780
GMGHHFLPSE PTKWNVEDVY EFIRSLPGCQ EIAEEFRAQE IDGQALLLLK EDHLMSAMNI 840
KLGPALKIYA RISMLKDS 858

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologPHC2537511E1BFG7Bos taurusPredictionMore>>
1:1 orthologPHC2487297J9P8A4Canis lupus familiarisPredictionMore>>
1:1 orthologPHC2A0A452F0Q9Capra hircusPredictionMore>>
1:1 orthologPHC21912Q8IXK0Homo sapiensPredictionMore>>
1:1 orthologPhc254383Q9QWH1CPOMus musculusPublicationMore>>
1:1 orthologPHC2456729H2PYL7Pan troglodytesPredictionMore>>
1:1 orthologPHC2I3LIR0Sus scrofaPredictionMore>>
1:1 orthologPHC2100351541G1T576Oryctolagus cuniculusPredictionMore>>
1:1 orthologPhc2313038D4A0M3Rattus norvegicusPredictionMore>>
1:1 orthologphc2b394177F6P2R0Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0000792 heterochromatin
GO:0005654 nucleoplasm
GO:0035102 PRC1 complex
GO:0042802 identical protein binding
GO:0008270 zinc ion binding
GO:0007283 spermatogenesis

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0479 Metal-binding
KW-1185 Reference proteome
KW-0862 Zinc
KW-0863 Zinc-finger

Interpro

InterPro ID InterPro Term
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR012313 Znf_FCS
IPR038603 Znf_FCS_sf

PROSITE

PROSITE ID PROSITE Term
PS50105 SAM_DOMAIN
PS51024 ZF_FCS

Pfam

Pfam ID Pfam Term
PF00536 SAM_1