| Tag | Content |
|---|---|
| Uniprot ID | Q9QWH1; B1AS98; B1ASA4; O88463; Q8K5D9; |
| Entrez ID | 54383 |
| Genbank protein ID | BAB93527.1; AAC23570.1; AAD00519.1; AAH57571.1; AAH71246.1; |
| Genbank nucleotide ID | XM_017320320.1; NM_001195130.1; XM_006503237.3; NM_018774.4; NM_001195083.1; XM_006503238.1; |
| Ensembl protein ID | ENSMUSP00000030588; ENSMUSP00000101689; ENSMUSP00000101690; |
| Ensembl nucleotide ID | ENSMUSG00000028796 |
| Gene name | Polyhomeotic-like protein 2 |
| Gene symbol | Phc2 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 16024804 |
| Functional description | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. |
| Sequence | MENELPVPHT SNRASVTTNT SGTNSSSGCI SSSGGGGGSG GRPTAPQISV YSGIPDRQTV 60 QVIQQALHRQ PSTAAQYLQQ MYAAQQQHLM LQTAALQQQH LSSAQLQSLA AVQQASLVAN 120 RQGSTPGSSV SSQAPAQSSS LNLAASPAAA QLINRAQSVN SAAASGLAQQ AVLLGNTSSP 180 ALTASQAQMY LRAQMLIFTP TATVATVQPE LCTGSPARPP TPAQVQNLTL RTQQTPAAAA 240 SGPPPTQPVL PSLALKPTPS SSQPLPAPPQ GRTMAQGSPA GAKPSGTDNA PETLKAGDGN 300 CNMEGRPGPG RAVPAVATHP LIAPAYAHLQ SHQLLPQPPA KHPQPQFVAQ QQPQPPRPAP 360 QVQSQPQLAS VSPSLALQSS PEDHALPLGS VTQALPLQCS TTHVHKPGNS QQCHLPTLDT 420 GSQNGHPEGG SHPPQRRFQH TSAVILQVQP ASPVTPQQCA PDDWKEVVPA EKSVPVARPG 480 PSPHQQAIIP AIPGGLPGPK SPNIQQCPAH ETGQGIVHAL TDLSSPGMTS GNGNSASSIA 540 GTAPQNGENK PPQAIVKPQI LTHVIEGFVI QEGAEPFPVG RSSLLVGNLK KKYAQGFLPE 600 KPPQQDHTTT TDSEMEEPYL QESKEEGTPL KLKCELCGRV DFAYKFKRSK RFCSMACAKR 660 YNVGCTKRVG LFHSDRSKLQ KAGTTTHNRR RASKASLPTL TKDTKKQPSG TVPLSVTAAL 720 QLAHSQEDSS RCSDNSSYEE PLSPISASSS TSRRRQGQRD LDLPDMHMRD LVGVGHHFLP 780 SEPTKWNVED VYEFIRSLPG CQEIAEEFRA QEIDGQALLL LKEDHLMSAM NIKLGPALKI 840 YARISMLKDS |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PHC2 | 537511 | E1BFG7 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | PHC2 | 487297 | J9P8A4 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | PHC2 | A0A452F0Q9 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | PHC2 | 1912 | Q8IXK0 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Phc2 | 54383 | Q9QWH1 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | PHC2 | 456729 | H2PYL7 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | PHC2 | I3LIR0 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | PHC2 | 100351541 | G1T576 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Phc2 | 313038 | D4A0M3 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | phc2b | 394177 | F6P2R0 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0003677 | DNA binding | IEA |
| GO:0005515 | protein binding | IPI |
| GO:0008270 | zinc ion binding | IEA |
| GO:0042802 | identical protein binding | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0007275 | multicellular organism development | IEA |
| GO:0007283 | spermatogenesis | IGI |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000792 | heterochromatin | IDA |
| GO:0005634 | nucleus | ISO |
| GO:0005634 | nucleus | IDA |
| GO:0005654 | nucleoplasm | ISO |
| GO:0031519 | PcG protein complex | ISO |
| GO:0031519 | PcG protein complex | IDA |
| GO:0035102 | PRC1 complex | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-1257604 | PIP3 activates AKT signaling | IEA |
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-212436 | Generic Transcription Pathway | IEA |
| R-MMU-2262752 | Cellular responses to stress | IEA |
| R-MMU-2559580 | Oxidative Stress Induced Senescence | IEA |
| R-MMU-2559583 | Cellular Senescence | IEA |
| R-MMU-2990846 | SUMOylation | IEA |
| R-MMU-3108214 | SUMOylation of DNA damage response and repair proteins | IEA |
| R-MMU-3108232 | SUMO E3 ligases SUMOylate target proteins | IEA |
| R-MMU-3899300 | SUMOylation of transcription cofactors | IEA |
| R-MMU-392499 | Metabolism of proteins | IEA |
| R-MMU-4551638 | SUMOylation of chromatin organization proteins | IEA |
| R-MMU-4570464 | SUMOylation of RNA binding proteins | IEA |
| R-MMU-597592 | Post-translational protein modification | IEA |
| R-MMU-6807070 | PTEN Regulation | IEA |
| R-MMU-73857 | RNA Polymerase II Transcription | IEA |
| R-MMU-74160 | Gene expression (Transcription) | IEA |
| R-MMU-8878171 | Transcriptional regulation by RUNX1 | IEA |
| R-MMU-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known | IEA |
| R-MMU-8943724 | Regulation of PTEN gene transcription | IEA |
| R-MMU-8953897 | Cellular responses to external stimuli | IEA |
| R-MMU-9006925 | Intracellular signaling by second messengers | IEA |
| Pfam ID | Pfam Term |
|---|---|
| PF00536 | SAM_1 |