| Tag | Content |
|---|---|
| Uniprot ID | F1M9H1 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSRNOP00000019396 |
| Ensembl nucleotide ID | ENSRNOG00000014395 |
| Gene name | GLI family zinc finger 3 |
| Gene symbol | Gli3 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MEAQSHSSTT TERKKAESSI AKCPTRTDVS EKAVASSTTS NEDESAGQIY HRERRNAITM 60 QPQSVQGLSK ISEEPSTSSD ERASLIKKEI HGSLPHLAEP SLPYRGTVFA MDPRNGYMEP 120 HYHPPHLFPA FHPPVPIDAR HHEGRYHYDP SPIPPLHVPS ALSSSPTYPD LPFIRISPHR 180 NPTAASESPF SPPHPYINPY MDYIRSLHSS PSLSMISAAR GLSPTDAPHA GVSPAEYYHQ 240 MALLTGQRSP YADILPSAAT AGAGAIHMEY LHAMDSTRFP SPRLSARPSR KRTLSISPLS 300 DHSFDLQTMI RTSPNSLVTI LNNSRSSSSA SGSYGHLSAS AISPALSFTY PSAPVSLHMH 360 QQILSRQQSL GSAFGHSPPL IHPAPTFPTQ RPIPGIPTVL NPVQVSSGPS ESSQSKPTSE 420 SAVSSTGDPM HNKRSKIKPD EDLPSPGSRG QQEQPEGTTL VKEEGDKDES KQEPEVIYET 480 NCHWEGCTRE FDTQDQLPQH INNDHIHGEK KEFVCRWLDC SREQKPFKAQ YMLVVHMRRH 540 TGEKPHKCTF EGCTKAYSRL ENLKTHLRSH TGEKPYVCEH EGCNKAFSNA SDRAKHQNRT 600 HSNEKPYVCK IPGCTKRYTD PSSLRKHVKT VHGPEAHVTK KQRGDMHPRP PPPRDSGSHS 660 QSRSPGRPTQ GAFGEQKELS NTTSKREECL QVKTVKAEKP MTSQPSPGGQ SSCSSQQSPI 720 SNYSNSGLEL PLTDGGSIAD LSAIDETPIM DSTISTATTA LALQGRRNPA GTKWMEHIKL 780 ERLKQVNGMF PRLNPILPSK APAVSPLIGN GTQSNNNYSS GGPGTLLPSR SDLSGVDFTV 840 LNTLNRRDSN TSTISSAYLS SRRSSGISPC FSSRRSSEAS QAEGRPQNVS VADSYDPIST 900 DASRRSSEAS QGDGLPSLLS LTPVQQYRLK AKYAAATGGP PPTPLPHMEK LSLKTRMALL 960 GEGRDSGVTL PPVHPPRRCS DGGGHTYSRR HLLPHDALAN SARRASDPVR TVSENMSLPR 1020 VQRFSSLNSF NPPNLPPSVE KRSLVLQNYT RQESTHPRYF QASPCPPSIT ENVALEALTM 1080 DADASLNDED FLPDDVVQYL NSQNQTGYGQ QLQSSISEDG KVAREPEDLD LPGLPDSHVG 1140 QQYPALEQPC SEGSKTDLPI QWNEVSSGSS DLSSSKLKCG QRPTVQQARG FGLYSNMVVH 1200 PQNLWKVGTG PAGGSQTLGE NGSSYSDPEH FAVHSGDGLG PSGDTFHEQA YKTQQYGSQL 1260 SRQPLTSSVL DSACGAGIQG SKLKGNSLQE NGGLLDFGLS MAPNELADNI VNGIQTQEQM 1320 GQGYIAPQLL SGSMQHQGPS RPGQQVLGQV GATSHINIYQ GTESCLPGTQ DKISQPSSMA 1380 VIRGYQPCAS YGGSRRQAMP RGSLTLQQGQ LSDVSQTSRV NSIKMEAHGQ SHQLCSSMQN 1440 YSGQFYDQTM GFSQQDRKAG SFSLSEANCL LQENGSENSE LLSPGVNQVT STVDSFESHD 1500 LEGVQIDFDA IIDDGDHTSL MSGALSPSII QNLSHSSSRL TTPRASLPFP SLSMSTTNMA 1560 IGDMSSLLTS LAEESKFLAV MQ 1582 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | GLI3 | 483244 | J9P1Q3 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | GLI3 | 102178142 | A0A452EPR3 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | GLI3 | 2737 | P10071 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Gli3 | 14634 | Q61602 | CPO,CLO | E13.0, E14.0, E13.5, E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | GLI3 | 463369 | H2QUH1 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | GLI3 | F1SSD9 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | GLI3 | 100355047 | G1SR94 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Gli3 | F1M9H1 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | gli3 | F1QSH8 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005930 | axoneme |
| GO:0005929 | cilium |
| GO:0005737 | cytoplasm |
| GO:0005829 | cytosol |
| GO:0016607 | nuclear speck |
| GO:0005634 | nucleus |
| GO:0017053 | transcriptional repressor complex |
| GO:0008013 | beta-catenin binding |
| GO:0003682 | chromatin binding |
| GO:0003700 | DNA-binding transcription factor activity |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0035035 | histone acetyltransferase binding |
| GO:0042826 | histone deacetylase binding |
| GO:0036033 | mediator complex binding |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| GO:0043565 | sequence-specific DNA binding |
| GO:0048856 | anatomical structure development |
| GO:0048646 | anatomical structure formation involved in morphogenesis |
| GO:0060873 | anterior semicircular canal development |
| GO:0009952 | anterior/posterior pattern specification |
| GO:0060840 | artery development |
| GO:0007411 | axon guidance |
| GO:0007420 | brain development |
| GO:0001658 | branching involved in ureteric bud morphogenesis |
| GO:0048754 | branching morphogenesis of an epithelial tube |
| GO:0043010 | camera-type eye development |
| GO:0048593 | camera-type eye morphogenesis |
| GO:0061005 | cell differentiation involved in kidney development |
| GO:0007417 | central nervous system development |
| GO:0021801 | cerebral cortex radial glia guided migration |
| GO:0048589 | developmental growth |
| GO:0009953 | dorsal/ventral pattern formation |
| GO:0048566 | embryonic digestive tract development |
| GO:0048557 | embryonic digestive tract morphogenesis |
| GO:0042733 | embryonic digit morphogenesis |
| GO:0030326 | embryonic limb morphogenesis |
| GO:0048598 | embryonic morphogenesis |
| GO:0048702 | embryonic neurocranium morphogenesis |
| GO:0048704 | embryonic skeletal system morphogenesis |
| GO:0030900 | forebrain development |
| GO:0021798 | forebrain dorsal/ventral pattern formation |
| GO:0021861 | forebrain radial glial cell differentiation |
| GO:0060364 | frontal suture morphogenesis |
| GO:0007507 | heart development |
| GO:0007442 | hindgut morphogenesis |
| GO:0021766 | hippocampus development |
| GO:0001701 | in utero embryonic development |
| GO:0048839 | inner ear development |
| GO:0001822 | kidney development |
| GO:0060366 | lambdoid suture morphogenesis |
| GO:0022018 | lateral ganglionic eminence cell proliferation |
| GO:0060875 | lateral semicircular canal development |
| GO:0021819 | layer formation in cerebral cortex |
| GO:0060173 | limb development |
| GO:0035108 | limb morphogenesis |
| GO:0097421 | liver regeneration |
| GO:0030324 | lung development |
| GO:0030879 | mammary gland development |
| GO:0060594 | mammary gland specification |
| GO:0030318 | melanocyte differentiation |
| GO:0001656 | metanephros development |
| GO:0046639 | negative regulation of alpha-beta T cell differentiation |
| GO:0043066 | negative regulation of apoptotic process |
| GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| GO:0045596 | negative regulation of cell differentiation |
| GO:0008285 | negative regulation of cell population proliferation |
| GO:0045665 | negative regulation of neuron differentiation |
| GO:0045879 | negative regulation of smoothened signaling pathway |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0045892 | negative regulation of transcription, DNA-templated |
| GO:0045060 | negative thymic T cell selection |
| GO:0021915 | neural tube development |
| GO:0048663 | neuron fate commitment |
| GO:0042475 | odontogenesis of dentin-containing tooth |
| GO:0048709 | oligodendrocyte differentiation |
| GO:0021631 | optic nerve morphogenesis |
| GO:0021543 | pallium development |
| GO:0007389 | pattern specification process |
| GO:0046638 | positive regulation of alpha-beta T cell differentiation |
| GO:0032332 | positive regulation of chondrocyte differentiation |
| GO:0002052 | positive regulation of neuroblast proliferation |
| GO:0045669 | positive regulation of osteoblast differentiation |
| GO:0042307 | positive regulation of protein import into nucleus |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0045893 | positive regulation of transcription, DNA-templated |
| GO:0030850 | prostate gland development |
| GO:0016485 | protein processing |
| GO:0009954 | proximal/distal pattern formation |
| GO:0042981 | regulation of apoptotic process |
| GO:1903010 | regulation of bone development |
| GO:0045595 | regulation of cell differentiation |
| GO:0042127 | regulation of cell population proliferation |
| GO:0010468 | regulation of gene expression |
| GO:0006355 | regulation of transcription, DNA-templated |
| GO:0043627 | response to estrogen |
| GO:0060021 | roof of mouth development |
| GO:0060367 | sagittal suture morphogenesis |
| GO:0007224 | smoothened signaling pathway |
| GO:0060831 | smoothened signaling pathway involved in dorsal/ventral neural tube patterning |
| GO:0021776 | smoothened signaling pathway involved in spinal cord motor neuron cell fate specification |
| GO:0021775 | smoothened signaling pathway involved in ventral spinal cord interneuron specification |
| GO:0021513 | spinal cord dorsal/ventral patterning |
| GO:0021522 | spinal cord motor neuron differentiation |
| GO:0021544 | subpallium development |
| GO:0033077 | T cell differentiation in thymus |
| GO:0021537 | telencephalon development |
| GO:0070242 | thymocyte apoptotic process |
| GO:0043586 | tongue development |
| GO:0035295 | tube development |
| GO:0071625 | vocalization behavior |
| GO:0042060 | wound healing |
| Pfam ID | Pfam Term |
|---|---|
| PF00096 | zf-C2H2 |