| Tag | Content |
|---|---|
| Uniprot ID | F1SSD9; A0A1I9Q606; F1SSE1; |
| Entrez ID | |
| Genbank protein ID | AOH69167.1 |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSSSCP00000017756 |
| Ensembl nucleotide ID | ENSSSCG00000016763 |
| Gene name | GLI family zinc finger 3 |
| Gene symbol | GLI3 |
| Organism | Sus scrofa |
| NCBI taxa ID | 9823 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MEAQSHSSTT TEKKKVENSI VKCSPRADVS EKAVASSTTS NEDESPGQTY HRERRNAVAM 60 QPQSVQGLGK VSEEPSTSSD ERASLIKKEI HGSLPHLAEP SVPYRGAVFA MDPRNGYMEP 120 HYHPPHLFPA FHPPVPIDAR HHEGRYHYDP SPVPPLHVPS ALSSSPAYSD LPLFRISPHR 180 NPAAASESPF SPPHPYVNPY MDYIRSLHSS PSLSMISAAR GLSPTDAPHA GVSPAEYYHQ 240 MALLAGQRSP YADIIPSAAT AGAGAIHMEY LHAMDGTRFP SPRLSARPSR KRTLSISPLS 300 DHSFDLQTMI RTSPNSLVTI LNNSRSSSSA SGSYGHLSAS AISPALSFTY PSAPVSLHMH 360 QQILSRQQSL GSAFGHSPPL IHPAPTFPTQ RPIPGIPTVL NPVQVSSGPS ESSQSKPTSE 420 SAVSSTGDLV HNKRSKIKPD EDLPSPGPRG PQEQPEGTTL VKEEGDKDES KQEPEVIYET 480 NCHWEGCSRE FDTQEQLVHH INNDHIHGEK KEFVCRWLDC SREQKPFKAQ YMLVVHMRRH 540 TGEKPHKCTF EGCTKAYSRL ENLKTHLRSH TGEKPYVCEH EGCNKAFSNA SDRAKHQNRT 600 HSNEKPYVCK IPGCTKRYTD PSSLRKHVKT VHGPEAHVTK KQRGDVHPRP PPPRDSGGHS 660 QARSPGRPTQ GALGEQKDLS STTSKREECL QVKAVKAEKP MTSQPSPGGQ SSCSSQQSPI 720 SNYSNSGLEL PLTDGGAVGD LSAIDETPIM DSTISTATTA LALQARRNPA GTKWMEHVKL 780 ERLKQVNGLL PRLNPIPPPK APVVSPLIGH STQPGTSCSL GGPAPLLPNR SDLSGVDLTV 840 LNVLDRRDSS TSTVSSAYLS SRRSSGISPC FSSRRSSEAS QAEGRPQNVS VADSYDPIST 900 DASRRSSEAS QGDGLPGLLS LTPAQQYRLK AKYAAATGGP PPTPLPNMER MSLKTRMALL 960 GEGREPAGTL PPVHPPRRCS DGGAHGHSRR PLLPQDALGI GVRRASDPVR TVSESLSLPR 1020 GQRFNSLHSF NPPGLAPALE KRHLVLQNYT RPEGGPARHF RASPCPPSIS ENVTMESLTL 1080 GATVDLNDED LLPDDVVQYL HSQNQAGYEQ PFPSALSDDG KVPHGPSLGS GPHDFDPLGL 1140 PDSHAGHTGQ QYRGLEPPCA DASKPDLPIQ WNEVSSGSAD LSSSKLKCGQ RPAAQQARAF 1200 GLYSSTGVHP QNSLRSGAGP AGGYPTLGEH GSAFGGPEPL VSHSGGAGTN GNAFHEQPCK 1260 AQQYGNCLAR QPGAPSLLDA GIQAAKLRSS MQGSGGQPDF GLLVAPNESA GSPGNGMPTQ 1320 DPVGQGYLAH QLLGDSMHPQ GPGRPAQHTL GQGSATSHLH VYQGPEGGLP GPPNIGGQLS 1380 GVAGIRGYQP CAGYGGSRRQ AGPRGSLALP PSGQLSDTSQ TCRVNGIKTE MPGPSHPLCS 1440 NVQSFSGQFY DRPVGFSQQD TKTGCFSISE ANCLLQGASA ETSELLSPGA NQVTSTVDSL 1500 DSHDLEGVQI DFDAILEDAD HASLMSGALS PSIIQNLSHS SSRLTTPRAA LPLPALPASS 1560 TNMAIGDMSS LLTSLAEESK FLAVMQ 1586 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | GLI3 | 483244 | J9P1Q3 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | GLI3 | 102178142 | A0A452EPR3 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | GLI3 | 2737 | P10071 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Gli3 | 14634 | Q61602 | CPO,CLO | E13.0, E14.0, E13.5, E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | GLI3 | 463369 | H2QUH1 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | GLI3 | F1SSD9 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | GLI3 | 100355047 | G1SR94 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Gli3 | F1M9H1 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | gli3 | F1QSH8 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005930 | axoneme |
| GO:0005829 | cytosol |
| GO:0016607 | nuclear speck |
| GO:0017053 | transcriptional repressor complex |
| GO:0008013 | beta-catenin binding |
| GO:0003682 | chromatin binding |
| GO:0003700 | DNA-binding transcription factor activity |
| GO:0035035 | histone acetyltransferase binding |
| GO:0042826 | histone deacetylase binding |
| GO:0036033 | mediator complex binding |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0060873 | anterior semicircular canal development |
| GO:0009952 | anterior/posterior pattern specification |
| GO:0060840 | artery development |
| GO:0007411 | axon guidance |
| GO:0001658 | branching involved in ureteric bud morphogenesis |
| GO:0048593 | camera-type eye morphogenesis |
| GO:0061005 | cell differentiation involved in kidney development |
| GO:0048589 | developmental growth |
| GO:0048557 | embryonic digestive tract morphogenesis |
| GO:0042733 | embryonic digit morphogenesis |
| GO:0048702 | embryonic neurocranium morphogenesis |
| GO:0021798 | forebrain dorsal/ventral pattern formation |
| GO:0021861 | forebrain radial glial cell differentiation |
| GO:0060364 | frontal suture morphogenesis |
| GO:0007507 | heart development |
| GO:0007442 | hindgut morphogenesis |
| GO:0021766 | hippocampus development |
| GO:0001701 | in utero embryonic development |
| GO:0060366 | lambdoid suture morphogenesis |
| GO:0022018 | lateral ganglionic eminence cell proliferation |
| GO:0060875 | lateral semicircular canal development |
| GO:0021819 | layer formation in cerebral cortex |
| GO:0030324 | lung development |
| GO:0060594 | mammary gland specification |
| GO:0030318 | melanocyte differentiation |
| GO:0001656 | metanephros development |
| GO:0046639 | negative regulation of alpha-beta T cell differentiation |
| GO:0043066 | negative regulation of apoptotic process |
| GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| GO:0008285 | negative regulation of cell population proliferation |
| GO:0045665 | negative regulation of neuron differentiation |
| GO:0045879 | negative regulation of smoothened signaling pathway |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0045060 | negative thymic T cell selection |
| GO:0042475 | odontogenesis of dentin-containing tooth |
| GO:0048709 | oligodendrocyte differentiation |
| GO:0021631 | optic nerve morphogenesis |
| GO:0046638 | positive regulation of alpha-beta T cell differentiation |
| GO:0032332 | positive regulation of chondrocyte differentiation |
| GO:0002052 | positive regulation of neuroblast proliferation |
| GO:0045669 | positive regulation of osteoblast differentiation |
| GO:0042307 | positive regulation of protein import into nucleus |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0016485 | protein processing |
| GO:0009954 | proximal/distal pattern formation |
| GO:1903010 | regulation of bone development |
| GO:0060021 | roof of mouth development |
| GO:0060367 | sagittal suture morphogenesis |
| GO:0060831 | smoothened signaling pathway involved in dorsal/ventral neural tube patterning |
| GO:0021776 | smoothened signaling pathway involved in spinal cord motor neuron cell fate specification |
| GO:0021775 | smoothened signaling pathway involved in ventral spinal cord interneuron specification |
| GO:0070242 | thymocyte apoptotic process |
| GO:0043586 | tongue development |
| GO:0071625 | vocalization behavior |
| Pfam ID | Pfam Term |
|---|---|
| PF00096 | zf-C2H2 |