| Tag | Content |
|---|---|
| Uniprot ID | H2QUH1; A0A2J8K9K4; |
| Entrez ID | 463369 |
| Genbank protein ID | JAA01207.1; JAA18558.1; |
| Genbank nucleotide ID | XM_009452941.2 |
| Ensembl protein ID | ENSPTRP00000032656 |
| Ensembl nucleotide ID | ENSPTRG00000019117 |
| Gene name | GLI family zinc finger 3 |
| Gene symbol | GLI3 |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MEAQSHSSTT TEKKKVENSI VKCSTRTDVS EKAVASSTTS NEDESPGQTY HRERRNAITM 60 QPQNVQGLSK VSEEPSTSSD ERASLIKKEI HGSLPHVAEP SVPYRGTVFA MDPRNGYMEP 120 HYHPPHLFPA FHPPVPIDAR HHEGRYHYDP SPIPPLHMTS ALSSSPTYPD LPFIRISPHR 180 NPAAASESPF SPPHPYINPY MDYIRSLHSS PSLSMISATR GLSPTDAPHA GVSPAEYYHQ 240 MALLTGQRSP YADIIPSAAT AGTGAIHMEY LHAMDSTRFP SPRLSARPSR KRTLSISPLS 300 DHSFDLQTMI RTSPNSLVTI LNNSRSSSSA SGSYGHLSAS AISPALSFTY SSAPVSLHMH 360 QQILSRQQSL GSAFGHSPPL IHPAPTFPTQ RPIPGIPTVL NPVQVSSGPS ESSQNKPTSE 420 SAVSSTGDPM HNKRSKIKPD EDLPSPGARG QQEQPEGTTL VKEEGDKDES KQEPEVIYET 480 NCHWEGCARE FDTQEQLVHH INNDHIHGEK KEFVCRWLDC SREQKPFKAQ YMLVVHMRRH 540 TGEKPHKCTF EGCTKAYSRL ENLKTHLRSH TGEKPYVCEH EGCNKAFSNA SDRAKHQNRT 600 HSNEKPYVCK IPGCTKRYTD PSSLRKHVKT VHGPEAHVTK KQRGDIHPRP PPPRDSGSHS 660 QSRSPGRPTQ GALGEQQDLS NTTSKREECL QVKTVKAEKP MTSQPSPGGQ SSCSSQQSPI 720 SNYSNSGLEL PLTDGGSIGD LSAIDETPIM DSTISTATTA LALQARRNPA GTKWMEHVKL 780 ERLKQVNGMF PRLNPILPPK APAVSPLIGN GTQSNNTCSL GGPMTLLPGR SDLSGVDVTM 840 LNMLNRRDSS ASTISSAYLS SRRSSGISPC FSSRRSSEAS QAEGRPQNVS VADSYDPIST 900 DASRRSSEAS QSDGLPSLLS LTPAQQYRLK AKYAAATGGP PPTPLPNMER MSLKTRLALL 960 GDALEPGVAL PPVHAPRRCS DGGAHGYGRR HLQPHDAPGH GVRRASDPVR TGSEGLALPR 1020 VPRFSSLSSC NPPAMATSAE KRSLVLQNYT RPEGGQSRNF HSSPCPPSIT ENVTLESLTM 1080 DADANLNDED FLPDDVVQYL NSQNQAGYEQ HFPSALPDDS KVPHGPGDFD APGLPDSHAG 1140 QQFHALEQPC PEGSKTDLPI QWNEVSSGSA DLSSSKLKCG PRPAVPQTRA FGFCNGMVVH 1200 PQNPLRSGPA GGYQTLGENS NPYGGPEHLM LHNSPGSGTS GNAFHEQPCK APQYGNCLNR 1260 QPVAPGALDG ACGAGIQASK LKSTPMQGSG GQLNFGLPVA PNESAGSMVN GMQNQDPVGQ 1320 GYLAHQLLGD SMQHPGAGRP GQQMLGQISA TSHINIYQGP ESCLPGAHGM GSQPSSLAVV 1380 RGYQPCASFG GSRRQAMPRD SLALQSGQLS DTSQTCRVNG IKMEMKGQPH PLCSNLQNYS 1440 GQFYDQTVGF SQQDTKAGSF SISDASCLLQ GTSAKNSELL SPGANQVTST VDSLDSHDLE 1500 GVQIDFDAII DDGDHSSLMS GALSPSIIQN LSYSSSRLTT PRASLPFPAL SMSTTNMAIG 1560 DMSSLLTSLA EESKFLAVMQ |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | GLI3 | 483244 | J9P1Q3 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | GLI3 | 102178142 | A0A452EPR3 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | GLI3 | 2737 | P10071 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Gli3 | 14634 | Q61602 | CPO,CLO | E13.0, E14.0, E13.5, E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | GLI3 | 463369 | H2QUH1 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | GLI3 | F1SSD9 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | GLI3 | 100355047 | G1SR94 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Gli3 | F1M9H1 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | gli3 | F1QSH8 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005930 | axoneme |
| GO:0005829 | cytosol |
| GO:0016607 | nuclear speck |
| GO:0005634 | nucleus |
| GO:0017053 | transcriptional repressor complex |
| GO:0008013 | beta-catenin binding |
| GO:0003682 | chromatin binding |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0035035 | histone acetyltransferase binding |
| GO:0042826 | histone deacetylase binding |
| GO:0036033 | mediator complex binding |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| GO:0060873 | anterior semicircular canal development |
| GO:0009952 | anterior/posterior pattern specification |
| GO:0060840 | artery development |
| GO:0007411 | axon guidance |
| GO:0001658 | branching involved in ureteric bud morphogenesis |
| GO:0048593 | camera-type eye morphogenesis |
| GO:0061005 | cell differentiation involved in kidney development |
| GO:0048589 | developmental growth |
| GO:0048557 | embryonic digestive tract morphogenesis |
| GO:0042733 | embryonic digit morphogenesis |
| GO:0048702 | embryonic neurocranium morphogenesis |
| GO:0021798 | forebrain dorsal/ventral pattern formation |
| GO:0021861 | forebrain radial glial cell differentiation |
| GO:0060364 | frontal suture morphogenesis |
| GO:0007507 | heart development |
| GO:0007442 | hindgut morphogenesis |
| GO:0021766 | hippocampus development |
| GO:0001701 | in utero embryonic development |
| GO:0060366 | lambdoid suture morphogenesis |
| GO:0022018 | lateral ganglionic eminence cell proliferation |
| GO:0060875 | lateral semicircular canal development |
| GO:0021819 | layer formation in cerebral cortex |
| GO:0030324 | lung development |
| GO:0060594 | mammary gland specification |
| GO:0030318 | melanocyte differentiation |
| GO:0001656 | metanephros development |
| GO:0046639 | negative regulation of alpha-beta T cell differentiation |
| GO:0043066 | negative regulation of apoptotic process |
| GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| GO:0008285 | negative regulation of cell population proliferation |
| GO:0045665 | negative regulation of neuron differentiation |
| GO:0045879 | negative regulation of smoothened signaling pathway |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0045060 | negative thymic T cell selection |
| GO:0042475 | odontogenesis of dentin-containing tooth |
| GO:0048709 | oligodendrocyte differentiation |
| GO:0021631 | optic nerve morphogenesis |
| GO:0046638 | positive regulation of alpha-beta T cell differentiation |
| GO:0032332 | positive regulation of chondrocyte differentiation |
| GO:0002052 | positive regulation of neuroblast proliferation |
| GO:0045669 | positive regulation of osteoblast differentiation |
| GO:0042307 | positive regulation of protein import into nucleus |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0016485 | protein processing |
| GO:0009954 | proximal/distal pattern formation |
| GO:1903010 | regulation of bone development |
| GO:0060021 | roof of mouth development |
| GO:0060367 | sagittal suture morphogenesis |
| GO:0007224 | smoothened signaling pathway |
| GO:0060831 | smoothened signaling pathway involved in dorsal/ventral neural tube patterning |
| GO:0021776 | smoothened signaling pathway involved in spinal cord motor neuron cell fate specification |
| GO:0021775 | smoothened signaling pathway involved in ventral spinal cord interneuron specification |
| GO:0070242 | thymocyte apoptotic process |
| GO:0043586 | tongue development |
| GO:0071625 | vocalization behavior |
| Pfam ID | Pfam Term |
|---|---|
| PF00096 | zf-C2H2 |