| Tag | Content |
|---|---|
| Uniprot ID | G1SR94 |
| Entrez ID | 100355047 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_002713771.3 |
| Ensembl protein ID | ENSOCUP00000005676 |
| Ensembl nucleotide ID | ENSOCUG00000006563 |
| Gene name | GLI family zinc finger 3 |
| Gene symbol | GLI3 |
| Organism | Oryctolagus cuniculus |
| NCBI taxa ID | 9986 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MEAQSHSSTT TEKKKVESSI VKCSTRTDVS EKAAASSTTS NEDESPGQTY HRERRNAITM 60 QPQTVQGLSK ISEEPSTSSE ERASLIKKEV HGSLPHLAEP SVPYRGTVFA MDPRNGYMEP 120 HYHPPHLFPA FHPPVPIDAR HHEGRYHYDP SPIPPLHVPS ALSSSPTYSD LPFIRISPHR 180 NPAASESPFS PPHPYINPYM DYIRSLHSSP SLSMISAARG LSPTDAPHAG VSPAEYYHQM 240 ALLAGQRSPY ADILPSAATA SAGAIHMEYL HAMDSTRFPS PRLSARPSRK RTLSISPLSD 300 HSFDLQTMIR TSPNSLVTIL NNSRSSSSAS GSYGHLSASA ISPALSFTYP SAPVSLHMHQ 360 QILSRQQSLG SAFGHSPPLI HPAPTFPTQR PIPGIPTVLN PIQVSSGPSE SSQNKPTSES 420 AVSSTGDPMH NKRSKIKPDE DLPSPGARGQ QEQPEGTTLV KEEGDKDESK QEPEVIYETN 480 CHWEGCAREF DTQEQLVHHI NNDHIHGEKK EFVCRWLDCS REQKPFKAQY MLVVHMRRHT 540 GEKPHKCTFE GCTKAYSRLE NLKTHLRSHT GEKPYVCEHE GCNKAFSNAS DRAKHQNRTH 600 SNEKPYVCKI PGCTKRYTDP SSLRKHVKTV HGPEAHVTKK QRGDMHPRPP PPRDPGSHSQ 660 SRSPGRPTQG ALGEQKDLSN TTSKREECLQ VKTVKAEKPM TSQPSPGGQS SCSSQQSPIS 720 NYSNSGLELP LTDGGSVADL SAIDETPIMD STISTATTAL ALQARRNPAG TKWMEHVKLE 780 RLTQVNGMLP RLNPILPPKA PAVSPLIGNG TQSNSSCSAG APVTLLPNRS DLSGVDITML 840 NMLNRRDSST STISSAYLSS RRSSGISPCF SSRRSSEASQ AEGRPQNVSV ADSYDPISTD 900 ASRRSSEASQ GDGLPSLLSL TPAQQYRLKA KYAAATGGPP PTPLPHMERL SLKTRMALLG 960 DGREAAVTLP PVHPPRRCSD GGSHSYGRRH LLPHDALGHG VRRASDPVRT VSENLSLPRV 1020 QRFSSLNSFN PPGLPPAAEK RNLVLQNYTR PEGGPARHFH ASPCPPSISE NVTLESLTMD 1080 ADASLNDEDF LPDDVVQYLN SQNQAGYGQH FPEDSKGTSG AGDFDQPGLP DSHLGQQYRA 1140 LEQPCTEGSK TDLPIQWNEV SSGSADLSSS KLKCGQRSAV PQARAFGLYN NTAVHPQHPA 1200 RSSGAGPAGG YPTLGESSSS YGGPEPLALH SGGGAGPGAN AFHEQPYKAQ QYGNCLSRQP 1260 GAPGVLDSAC GAGVPGSKLK STAMQGNGAP LDFGLSVVPS EPAGGMLSGM QAQDPVGQGF 1320 LAHQLLSDSM QHQGAGRPGQ QMLGQVSATS HINIFQGPES CLPGTHSQPS SLAGVRGYQL 1380 CAGYGGSRRQ AVPRGSLPLQ HGQQGDSSQT CRVNGIKMEI QGQPQQLCSN MQNYSGQFYD 1440 QTVGFSQQDM KAGSFSVAEA SCLLQGASAE NSELLSPGAN QVTSTVDSLD SHDLEGVQID 1500 FDAIIDDGDH ASLMSGALSP SIIQNLSHSS SRLTTPRASL PFPALSVSTT NMAIGDMSSL 1560 LTSLAEESKF LAVMQ 1575 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | GLI3 | 483244 | J9P1Q3 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | GLI3 | 102178142 | A0A452EPR3 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | GLI3 | 2737 | P10071 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Gli3 | 14634 | Q61602 | CPO,CLO | E13.0, E14.0, E13.5, E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | GLI3 | 463369 | H2QUH1 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | GLI3 | F1SSD9 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | GLI3 | 100355047 | G1SR94 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Gli3 | F1M9H1 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | gli3 | F1QSH8 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005930 | axoneme |
| GO:0005829 | cytosol |
| GO:0016607 | nuclear speck |
| GO:0017053 | transcriptional repressor complex |
| GO:0008013 | beta-catenin binding |
| GO:0003682 | chromatin binding |
| GO:0003700 | DNA-binding transcription factor activity |
| GO:0035035 | histone acetyltransferase binding |
| GO:0042826 | histone deacetylase binding |
| GO:0036033 | mediator complex binding |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0060873 | anterior semicircular canal development |
| GO:0009952 | anterior/posterior pattern specification |
| GO:0060840 | artery development |
| GO:0007411 | axon guidance |
| GO:0001658 | branching involved in ureteric bud morphogenesis |
| GO:0048593 | camera-type eye morphogenesis |
| GO:0061005 | cell differentiation involved in kidney development |
| GO:0048589 | developmental growth |
| GO:0048557 | embryonic digestive tract morphogenesis |
| GO:0042733 | embryonic digit morphogenesis |
| GO:0048702 | embryonic neurocranium morphogenesis |
| GO:0021798 | forebrain dorsal/ventral pattern formation |
| GO:0021861 | forebrain radial glial cell differentiation |
| GO:0060364 | frontal suture morphogenesis |
| GO:0007507 | heart development |
| GO:0007442 | hindgut morphogenesis |
| GO:0021766 | hippocampus development |
| GO:0001701 | in utero embryonic development |
| GO:0060366 | lambdoid suture morphogenesis |
| GO:0022018 | lateral ganglionic eminence cell proliferation |
| GO:0060875 | lateral semicircular canal development |
| GO:0021819 | layer formation in cerebral cortex |
| GO:0030324 | lung development |
| GO:0060594 | mammary gland specification |
| GO:0030318 | melanocyte differentiation |
| GO:0001656 | metanephros development |
| GO:0046639 | negative regulation of alpha-beta T cell differentiation |
| GO:0043066 | negative regulation of apoptotic process |
| GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| GO:0008285 | negative regulation of cell population proliferation |
| GO:0045665 | negative regulation of neuron differentiation |
| GO:0045879 | negative regulation of smoothened signaling pathway |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0045060 | negative thymic T cell selection |
| GO:0042475 | odontogenesis of dentin-containing tooth |
| GO:0048709 | oligodendrocyte differentiation |
| GO:0021631 | optic nerve morphogenesis |
| GO:0046638 | positive regulation of alpha-beta T cell differentiation |
| GO:0032332 | positive regulation of chondrocyte differentiation |
| GO:0002052 | positive regulation of neuroblast proliferation |
| GO:0045669 | positive regulation of osteoblast differentiation |
| GO:0042307 | positive regulation of protein import into nucleus |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0016485 | protein processing |
| GO:0009954 | proximal/distal pattern formation |
| GO:1903010 | regulation of bone development |
| GO:0060021 | roof of mouth development |
| GO:0060367 | sagittal suture morphogenesis |
| GO:0060831 | smoothened signaling pathway involved in dorsal/ventral neural tube patterning |
| GO:0021776 | smoothened signaling pathway involved in spinal cord motor neuron cell fate specification |
| GO:0021775 | smoothened signaling pathway involved in ventral spinal cord interneuron specification |
| GO:0070242 | thymocyte apoptotic process |
| GO:0043586 | tongue development |
| GO:0071625 | vocalization behavior |
| Pfam ID | Pfam Term |
|---|---|
| PF00096 | zf-C2H2 |