| Tag | Content |
|---|---|
| Uniprot ID | J9P1Q3 |
| Entrez ID | 483244 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_540363.4 |
| Ensembl protein ID | ENSCAFP00000039478 |
| Ensembl nucleotide ID | ENSCAFG00000003535 |
| Gene name | GLI family zinc finger 3 |
| Gene symbol | GLI3 |
| Organism | Canis lupus familiaris |
| NCBI taxa ID | 9615 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MEAQNHSSTT TEKKKVDTSI VKCSSRTDVS EKAVASSTTS NEDESPGQTY HRERRNAVTM 60 QPQSVQGLGK ISEEPSTSSE ERASLIKKEI HGSLPHLAEP SVPYRGAVFA MDPRNGYMEP 120 HYHPSHLFPA FHPPVPIDAR HHEGRYHYDP SPIPPLHVPS ALSSSPTYSD LPFIRISPHR 180 NPAAASEPPF SPPHPYINPY MDYIRSLHSP SLSMISAARG LSPTDAPHAG VSPAEYYHQM 240 ALLAGQRSPY ADIIPSAATA GAGAIHMEYL HAMDSTRFPS PRLSARPSRK RTLSISPLSD 300 HSFDLQTMIR TSPNSLVTIL NNSRSSSSAS GSYGHLSASA ISPALSFTYP SAPVSLHMHQ 360 QILSRQQSLG SAFGHSPPLI HPAPTFPTQR PIPGIPTVLN PVQVTSGPSE SSQNKPTSES 420 AVSSTGDLMH NKRSKIKPDE DLPSPGPRGQ QEQPEGTTLV KEEGDRDESK QEPEVIYETN 480 CHWEGCTREF DTQEQLVHHI NNDHIHGEKK EFVCRWMDCS REQKPFKAQY MLVVHMRRHT 540 GEKPHKCTFE GCTKAYSRLE NLKTHLRSHT GEKPYVCEHE GCNKAFSNAS DRAKHQNRTH 600 SNEKPYVCKI PGCTKRYTDP SSLRKHVKTV HGPEAHVTKK QRGDIHPRPP PPRDSGSHSQ 660 SRSPGRQTQG ALGEQKDLSN TTSKREECLQ VKAVKAEKPM TSQPSPGGES SCSSQQSPIS 720 NYSNSGLELP LTDGGGVGDL GTIDETPIMD STISTATTAL ALQARRNPAG AKWMEHVKLE 780 RLKQVNGMLP RLNPVLPPKA PAVSPLIGNG TQPSTSCSLG GPITLLPNRS DLSGVDITML 840 NMLNRRDSSA STISSAYLSS RRSSGISPCF SSRRSSEASQ AEGRPQNVSV ADSYDPISTD 900 ASRRSSEASQ GDGLPSLLSL TPAQQYRLKA KYAAATGGPP PTPLPNMERM SLKTRMALLG 960 DAREPAGALP PVPPPRRCSD GGAHGYGRRP LLPLDALGNG VRRASDPVRT ASDGLSLPRV 1020 QRFGSLHSFN PPGPPPTLEK RHLVLQNYTR PDGGQPRHFP PSPCPPSITE NVTLEALTMD 1080 ADVSLTDEDF LPDDVVQYLN SQNPAGFEQP FQSAVSEDSK APHGPGDFDG PGLPDGHAGH 1140 PGHPGHPGPA GQPYRPLEQP CPEASKADLP IQWNEVSSGS ADLCSSKLKC GQRPAAQQAR 1200 AFGFYGNVGA PPQPALRSGP GPAGAYAPLA EPGPAYGGPE PLAGHGAGAG SPGDAFHEQP 1260 CKAPQFGSCL GRQPGAPGPL DGGCAAAAKL KSSTAPGPGG QPDFGLLPGP GESAGGAGSG 1320 LATQDLAGQG YLAHPLLHDG VPHQGAGRAG QQMLGQVSAT SHVNVYLGPE GGLPGPPCVS 1380 GQPAGLAATR GYQPCAAYGG GRRQAVPRGS LALQQAQLSD PSPTCRVNGI KVEMQGQPHQ 1440 LCSNTQSYSG QFYDQTVGFS QQDMKTGSFS ISEASCLLQG ASAENSELLS PGANQVTSTV 1500 DSLDSHDLEG VQIDFDAIID DGDHASLMSG ALSPSIIQNL SHSSSRLTTP RASLPLPTLS 1560 VSTTNMAIGD MSSLLTSLAE ESKFLAVMQ 1589 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | GLI3 | 483244 | J9P1Q3 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | GLI3 | 102178142 | A0A452EPR3 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | GLI3 | 2737 | P10071 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Gli3 | 14634 | Q61602 | CPO,CLO | E13.0, E14.0, E13.5, E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | GLI3 | 463369 | H2QUH1 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | GLI3 | F1SSD9 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | GLI3 | 100355047 | G1SR94 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Gli3 | F1M9H1 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | gli3 | F1QSH8 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005634 | nucleus |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| GO:0009952 | anterior/posterior pattern specification |
| GO:0009953 | dorsal/ventral pattern formation |
| GO:0048568 | embryonic organ development |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0007224 | smoothened signaling pathway |
| Pfam ID | Pfam Term |
|---|---|
| PF00096 | zf-C2H2 |