| Tag | Content |
|---|---|
| Uniprot ID | F1QSH8 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSDARP00000058991 |
| Ensembl nucleotide ID | ENSDARG00000052131 |
| Gene name | GLI family zinc finger 3 |
| Gene symbol | gli3 |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MEPQFQTSSS TEKRMENVVG TNSAPTRTDI SEKAVASSTT SNEDDSSGSP YHLERRNTIS 60 AQTDVVNTSG KVSEEPSTST DERPPLVKKE LQSSLHRLAD HTLPYRGTLF AMDPRSGYLD 120 PHYTAPQFFP AFHHPVPIDD RHTQGRYIYE PSPVPSLHMP PALAASPTFS DISLIRISPH 180 RNPSMGTDSP FNPSHPYINP YMDYIRSLHS SPSLSMVSAA RGLSPADTHH TGLTTAEYYH 240 QMALLAGHRS PYADLIPSVG STTGPASSAL HMEYLQAMES SRFPSPRLIN RPSRKRPIPN 300 SPSLSDPSFD LQAMIRTSPN SLVTILNNSR SSSSNSGSYG HLSAGTISPA LSFAYPPTPV 360 ALQMHQQLIS RQPGIVGSAF GHSPPLMHSA PAFSTQRPVP AIQTSSLAPT ERSIVSNDSQ 420 SKPTSESAVS STGDPMNHKR SKLKPEEEPP SPRAVSMQEQ MNGMTLVKEE GDKEEGKQEP 480 EVVYETNCHW DGCCREFDTQ EQLVHHINND HIHGEKKEFV CRWEECSREQ KPFKAQYMLV 540 VHMRRHTGEK PHKCTFEGCS KAYSRLENLK THLRSHTGEK PYVCEHEGCN KAFSNASDRA 600 KHQNRTHSNE KPYVCKIPGC TKRYTDPSSL RKHVKTVHGP EAHVTKKQRG ETYPRPPPQP 660 REPGATTDQK EYTHATSKQD ECLQVKSIKT EKPMTSQSSP GSQSSCSSDQ SINGPHVSQG 720 VQLTVNSIGL AGEVAMLEDM ENEEEDEENR EREKEDAPIM DSTVSTATSS AATIVLQTHR 780 SVGRPLRWME HVKMERLRQV NGAVPRLGFL PPTPPPKGQA MPALTGKGQC LGRSTSVRVP 840 PCPEPSNTEL TILSLLHERR DSSGSNTSSA YLSSSRRSSG ISPCFSSRCS SQASLSEYSP 900 HRHIHNLSAT DSYDPISTDA SRRSSEASQY DGGSSSAVVF GGSGVFKGSG MGSRGDLNLT 960 PAQHYSLKAK YAAATGGPPP TPLPSMGHIN LKSHFALKED RKDTGQLTLP PLVRSRRCSD 1020 GAHNSHDSQA VYQRKGTYFG GGPGKNDRRA SDPTHHKQNL SSYGLPQVRH FSSLNNMTSS 1080 PNPASYGYLN REDHSLNLQN STCHVDSFQS GLHSPCPPSI MEQSALENIS INQDGLLLRV 1140 NENIQSDFMQ YLHSQDQESI INQDNHRPIF NPANDQNFLS PQQHQEGVEQ EDTSIDLMPI 1200 QSNEVSSGSA DVTIPRQPFQ RCGRWSDQSG SVSNAFGRFG NMVVQQQPID FIDQHSALQH 1260 MGGISYGCRN SEQHLQVAKP AQEKSRMKTG IKTESSSTFQ LESKHSNFGR PDFSHIFSAP 1320 IHQKCSQHTV VSQSYPQQNQ ITNQDSSNLF LQRPGNCSLL LAYRPQPAVN TSYSTRQDIN 1380 SHNVQSCHPQ SLNNRLGTNC SPSNQVSVVK LDQVNHLQIN SCSSIQQQTP VFIDKCFDLE 1440 KSKLSHAIVQ SCLMESLMAE KERTSKVLLS SGVGQVTSTV ERSPAEKVGL GICSIGDDSY 1500 DQGSVVSSSQ LSNSHDSFAF HSVNPGTNNM AISDMSSLLT TLAEESKFLA IIQ 1553 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | GLI3 | 483244 | J9P1Q3 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | GLI3 | 102178142 | A0A452EPR3 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | GLI3 | 2737 | P10071 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Gli3 | 14634 | Q61602 | CPO,CLO | E13.0, E14.0, E13.5, E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | GLI3 | 463369 | H2QUH1 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | GLI3 | F1SSD9 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | GLI3 | 100355047 | G1SR94 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Gli3 | F1M9H1 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | gli3 | F1QSH8 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0005634 | nucleus |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0046872 | metal ion binding |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0009952 | anterior/posterior pattern specification |
| GO:0009953 | dorsal/ventral pattern formation |
| GO:0048568 | embryonic organ development |
| GO:0048699 | generation of neurons |
| GO:0050767 | regulation of neurogenesis |
| GO:0006357 | regulation of transcription by RNA polymerase II |
| GO:0006355 | regulation of transcription, DNA-templated |
| GO:0007224 | smoothened signaling pathway |
| Pfam ID | Pfam Term |
|---|---|
| PF00096 | zf-C2H2 |