| Tag | Content |
|---|---|
| Uniprot ID | F1MGP5 |
| Entrez ID | 507991 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_005221640.3 |
| Ensembl protein ID | ENSBTAP00000012372 |
| Ensembl nucleotide ID | ENSBTAG00000009401 |
| Gene name | Methionine synthase reductase |
| Gene symbol | MTRR |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MRRFLLLYAT QRGQAKAIAE EISEKAVTYG FSADLHCISE SDKYDLKTET APLVMVVSTT 60 GNGDPPDTAR KFVKAIKDKT LPPDFLAHLR YGLLGLGDSE YTYFCNGGKV IDKRLQELGA 120 QRFYDTGHAD DCVGLELVVE PWINGLWAAL EKHFLSNRGR EDTSETLTMA SHASRDAVTP 180 ELLHVESQVG LLKLDDSGGK AAKVLEQNAV NSNQSSTLIV DFEASLTHSV PPLSQASLNI 240 PSLPPEYLEV HLEEALGQEE SHASVSLVDP VFHVPVSKAV QLTTNDAIKT TLLIELDISK 300 TDFSYQPGDA FNVICPNSDS EVQFLLQRLQ LADRREHHVA VTIKADTRKK GAALPQHVPE 360 RCSLQFLLTW CLEIRAVPKK AFLRALADHT GDSAERRRLQ ELCSRQGAAD YTRFVREAGA 420 CLSDLLRAFP SCQPPLGLLL EHLPKLQPRP YSCASSSLFH PGKLHFIFNI VEFLSNTTEV 480 ILRRGVCTGW LATLVESILQ PYMCANHVDG KKALAPKISI SPRTTNSFHL PNDPSVPIIM 540 VGPGAGVAPF IGFLQHREKL QEQHPGGHFG ATWLFFGCRH KERDYLFRDE LRHFLKCGVL 600 THLEVSFSRD VAVGEEEGPA KYVQDSLQRH SKQVAGVLLQ DSGYVYVCGD AKNMAKDVHD 660 ALVEIISRET GVEKLEAMKT LATLKEEKRY LQDIW 695 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | MTRR | 507991 | F1MGP5 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | MTRR | 102171193 | A0A452F9C4 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | MTRR | 4552 | Q9UBK8 | CPO,CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Mtrr | 210009 | A0A0R4J0G9 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | MTRR | 461717 | H2QQM3 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | MTRR | F1S0T1 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Mtrr | 290947 | Q498R1 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | mtrr | 560667 | F1RE28 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005829 | cytosol |
| GO:0030586 | [methionine synthase] reductase activity |
| GO:0050444 | aquacobalamin reductase (NADPH) activity |
| GO:0071949 | FAD binding |
| GO:0050660 | flavin adenine dinucleotide binding |
| GO:0010181 | FMN binding |
| GO:0070402 | NADPH binding |
| GO:0003958 | NADPH-hemoprotein reductase activity |
| GO:0016491 | oxidoreductase activity |
| GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen |
| GO:0046655 | folic acid metabolic process |
| GO:0043418 | homocysteine catabolic process |
| GO:0050667 | homocysteine metabolic process |
| GO:0009086 | methionine biosynthetic process |
| GO:1904042 | negative regulation of cystathionine beta-synthase activity |
| Keyword ID | Keyword Term |
|---|---|
| KW-1185 | Reference proteome |
| InterPro ID | InterPro Term |
|---|---|
| IPR003097 | CysJ-like_FAD-binding |
| IPR017927 | FAD-bd_FR_type |
| IPR001094 | Flavdoxin-like |
| IPR008254 | Flavodoxin/NO_synth |
| IPR001709 | Flavoprot_Pyr_Nucl_cyt_Rdtase |
| IPR029039 | Flavoprotein-like_sf |
| IPR039261 | FNR_nucleotide-bd |
| IPR023173 | NADPH_Cyt_P450_Rdtase_alpha |
| IPR001433 | OxRdtase_FAD/NAD-bd |
| IPR017938 | Riboflavin_synthase-like_b-brl |