| Tag | Content |
|---|---|
| Uniprot ID | H2QQM3 |
| Entrez ID | 461717 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_001145250.4 |
| Ensembl protein ID | ENSPTRP00000028690 |
| Ensembl nucleotide ID | ENSPTRG00000016721 |
| Gene name | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase |
| Gene symbol | MTRR |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MGAASVRAGA RLVEVALCSF TVTCLEVMRR FLLLYATQQG QAKAIAEEIC EQAVVHGFSA 60 DLHCISESDK YDLKTETAPL VVVVSTTGTG DPPDTARKFV KEIQNQTLPV DFFAHLRYGL 120 LGLGDSEYTY FCNGGKIIDK RLQELGARHF YDTGHADDCV GLELVVEPWI AGLWPALRKH 180 FRSSRGQEEI SGALPVASPA SLRTDLVKSE LLHIESQVEL LRFDDSGGKD SEVLKQNAVN 240 SNQSNVLIED FESSLTRSEP PLSQASLNIP ALPPEYLQVY LQESLGQEES QASVTSADPI 300 FQVPISKAVQ LTTNDAIKTT LLVELDISNT DFSYQPGDAF SVICPNSDSE VQSLLQRLQL 360 EDKREHCVLL KIKADTKKKG AALPQHIPAG CSLQFIFTWC LEIRAIPKKA FLRALVDYTS 420 DSAEKRRLQE LCSKQGAADY SRFVRDACAC LLDLLLAFPS CQPPLSLLLE HLPKLQPRPY 480 SCASSSLFHP GKLHFVFNIV EFLSTATTEV LRKGVCTGWL ALLVASVLQP NIHSSHEDSG 540 KALAPKISIS SRTTNSFHLP DDPSIPIIMV GPGTGIAPFI GFLQHREKLQ EQHPDGNFGA 600 MWLFFGCRHK DRDYLFRKEL RHFLKHGILT HLKVSFSRDA PVGEEEAPAK YVQDNIQLHG 660 QQVARILLQE NGHIYVCGDA KNMAKDVHDA LVEIISKEVG VEKLEAMKTL ATLKEEKRYL 720 QDIWS 725 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | MTRR | 507991 | F1MGP5 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | MTRR | 102171193 | A0A452F9C4 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | MTRR | 4552 | Q9UBK8 | CPO,CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Mtrr | 210009 | A0A0R4J0G9 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | MTRR | 461717 | H2QQM3 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | MTRR | F1S0T1 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Mtrr | 290947 | Q498R1 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | mtrr | 560667 | F1RE28 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005829 | cytosol |
| GO:0030586 | [methionine synthase] reductase activity |
| GO:0050444 | aquacobalamin reductase (NADPH) activity |
| GO:0071949 | FAD binding |
| GO:0050660 | flavin adenine dinucleotide binding |
| GO:0010181 | FMN binding |
| GO:0070402 | NADPH binding |
| GO:0003958 | NADPH-hemoprotein reductase activity |
| GO:0016491 | oxidoreductase activity |
| GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen |
| GO:0046655 | folic acid metabolic process |
| GO:0043418 | homocysteine catabolic process |
| GO:0050667 | homocysteine metabolic process |
| GO:0009086 | methionine biosynthetic process |
| GO:1904042 | negative regulation of cystathionine beta-synthase activity |
| Keyword ID | Keyword Term |
|---|---|
| KW-1185 | Reference proteome |
| InterPro ID | InterPro Term |
|---|---|
| IPR003097 | CysJ-like_FAD-binding |
| IPR017927 | FAD-bd_FR_type |
| IPR001094 | Flavdoxin-like |
| IPR008254 | Flavodoxin/NO_synth |
| IPR001709 | Flavoprot_Pyr_Nucl_cyt_Rdtase |
| IPR029039 | Flavoprotein-like_sf |
| IPR039261 | FNR_nucleotide-bd |
| IPR023173 | NADPH_Cyt_P450_Rdtase_alpha |
| IPR001433 | OxRdtase_FAD/NAD-bd |
| IPR017938 | Riboflavin_synthase-like_b-brl |