| Tag | Content |
|---|---|
| Uniprot ID | F1RE28 |
| Entrez ID | 560667 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_684065.4 |
| Ensembl protein ID | ENSDARP00000066758 |
| Ensembl nucleotide ID | ENSDARG00000045398 |
| Gene name | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase |
| Gene symbol | mtrr |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MPCEAAAHFL ILYGSQRGQA QSIAEEICQQ AAEHGFTADI SCLSKHDKYN LDSESRPVVF 60 VVSTTGDGDP PDTALKFVRK IKNKSLPHDH LSHLRYALLG LGDTNYANFC NGGKTIDSYL 120 QKLGAKHFYA TGHADDGTGL EVVVDPWIEG LWDALKKAFS TMSTSDQQTL SDCTQDSNHQ 180 NASDQKKNLE VDLQLLKLSE VDSPKGKTVT SDSIATEIGS TSSVASLKES VPPLSESVLN 240 VPALPPSYLE ILLVGTENVE ETVLPDKDGY FEVPISKAVQ LTQDDAVKTA ILLELDISQQ 300 QEQVYQPGDA FDILCPNRDS EVEELLLKLD LQMQKNCTVQ VNLLKNTSKK AAKVPLHIPQ 360 NGSLQFILTW CLEIRSTPKK AFLRALVDFT QNASEKRRLL ELCSKQGSAD YNSFVRDSSV 420 CVLDLLRAFP SCCPPLSLLF EHLPKLQPRA YSAASSSLQH PGKVHLVFNV VEFPARPEHP 480 ARKGLCTGWL VDHVSSILEP HGTALASERP GTSALPKVHV RARPSSTFHL PSDPCVPVVM 540 VGPGTGVAPF IGFLQQREKE REANQEATFG EMWLFFGCRH KDKDFLFREE LEKFVHNGTL 600 SHLIVCFSRD EPDAAETVNR PTYVQHNLIL HAKNLAKILL EDKGCLYVCG DAKNMAKDVN 660 DTLLEIIGNE LQLDKLDAMK IVAGLREDKR YLQDIWS 697 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | MTRR | 507991 | F1MGP5 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | MTRR | 102171193 | A0A452F9C4 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | MTRR | 4552 | Q9UBK8 | CPO,CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Mtrr | 210009 | A0A0R4J0G9 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | MTRR | 461717 | H2QQM3 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | MTRR | F1S0T1 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Mtrr | 290947 | Q498R1 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | mtrr | 560667 | F1RE28 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005829 | cytosol |
| GO:0030586 | [methionine synthase] reductase activity |
| GO:0050660 | flavin adenine dinucleotide binding |
| GO:0010181 | FMN binding |
| GO:0016491 | oxidoreductase activity |
| GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen |
| GO:0050667 | homocysteine metabolic process |
| GO:0009086 | methionine biosynthetic process |
| InterPro ID | InterPro Term |
|---|---|
| IPR003097 | CysJ-like_FAD-binding |
| IPR017927 | FAD-bd_FR_type |
| IPR001094 | Flavdoxin-like |
| IPR008254 | Flavodoxin/NO_synth |
| IPR001709 | Flavoprot_Pyr_Nucl_cyt_Rdtase |
| IPR029039 | Flavoprotein-like_sf |
| IPR039261 | FNR_nucleotide-bd |
| IPR023173 | NADPH_Cyt_P450_Rdtase_alpha |
| IPR001433 | OxRdtase_FAD/NAD-bd |
| IPR017938 | Riboflavin_synthase-like_b-brl |