Gene: EDNRB

Basic information

Tag Content
Uniprot ID F1PB15
Entrez ID 403862
Genbank protein ID
Genbank nucleotide ID XM_005633820.2
Ensembl protein ID ENSCAFP00000007760
Ensembl nucleotide ID ENSCAFG00000005187
Gene name Endothelin receptor type B
Gene symbol EDNRB
Organism Canis lupus familiaris
NCBI taxa ID 9615
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MKPLLSWCRR ALVALILACS GAGVQGEERG FPPARATVPL WGPGEITTPP TEASWSKGPN 60
ASVPWSSAPP QMPKGGRTAG GPPRTLTPPP CEKSIEIKET FKYINTVVSC LVFVLGIIGN 120
STLLRIIYKN KCMRNGPNIL IASLALGDLL HIIIDIPITV YKLLAEDWPF GVEMCKLVPF 180
IQKASVGITV LSLCALSIDR YRAVASWSRI KGIGVPKWTA VEIVLIWVVS VVLAVPEAVG 240
FDMITIDYKG RYLRICLLHP TQKTAFMQFY KTAKDWWLFS FYFCLPLAIT AFFYTLMTCE 300
MLRKKSGMQI ALNDHLKQRR EVAKTVFCLV LVFALCWLPL HLSRILKLTI YDQNDPNRCE 360
LLSFLLVLDY IGINMASLNS CINPIALYLV SKRFKNCFKS CLCCWCQSFE EKQSLEEKQS 420
CLKFKANDHG YDNFRSSNKY SSS 443

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologEDNRB281750P28088Bos taurusPredictionMore>>
1:1 orthologEDNRB403862F1PB15Canis lupus familiarisPredictionMore>>
1:1 orthologEDNRB102186699A0A452E880Capra hircusPredictionMore>>
1:1 orthologEDNRB1910P24530Homo sapiensPredictionMore>>
1:1 orthologEdnrb13618P48302CPO,CLPMus musculusPublicationMore>>
1:1 orthologEDNRB452613H2Q7N9Pan troglodytesPredictionMore>>
1:1 orthologEDNRB414911P35463Sus scrofaPredictionMore>>
1:1 orthologEDNRB100009477D6CI21Oryctolagus cuniculusPredictionMore>>
1:1 orthologEdnrb50672P21451Rattus norvegicusPredictionMore>>
1:1 orthologednrba30442Q9DGM2Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0016021 integral component of membrane
GO:0005886 plasma membrane
GO:0004962 endothelin receptor activity
GO:0017046 peptide hormone binding
GO:0019722 calcium-mediated signaling
GO:0048484 enteric nervous system development
GO:0035645 enteric smooth muscle cell differentiation
GO:0048246 macrophage chemotaxis
GO:0030318 melanocyte differentiation
GO:0032269 negative regulation of cellular protein metabolic process
GO:0014043 negative regulation of neuron maturation
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001755 neural crest cell migration
GO:0007422 peripheral nervous system development
GO:0007497 posterior midgut development
GO:0008217 regulation of blood pressure
GO:0006885 regulation of pH
GO:0014826 vein smooth muscle contraction

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0297 G-protein coupled receptor
KW-0472 Membrane
KW-0675 Receptor
KW-1185 Reference proteome
KW-0732 Signal
KW-0807 Transducer
KW-0812 Transmembrane
KW-1133 Transmembrane helix

Interpro

InterPro ID InterPro Term
IPR000499 Endthln_rcpt
IPR001112 ETB_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM

PROSITE

PROSITE ID PROSITE Term
PS00237 G_PROTEIN_RECEP_F1_1
PS50262 G_PROTEIN_RECEP_F1_2

Pfam

Pfam ID Pfam Term
PF00001 7tm_1