| Tag | Content |
|---|---|
| Uniprot ID | P48302; Q542M3; |
| Entrez ID | 13618 |
| Genbank protein ID | AAB60508.1; BAC36337.1; BAC39465.1; AAH26553.1; BAC38908.1; BAC38409.1; |
| Genbank nucleotide ID | NM_001136061.2; NM_001276296.1; XM_006518515.2; NM_007904.4; |
| Ensembl protein ID | ENSMUSP00000154806; ENSMUSP00000126057; ENSMUSP00000022718; |
| Ensembl nucleotide ID | ENSMUSG00000022122 |
| Gene name | Endothelin receptor type B |
| Gene symbol | Ednrb |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO,CLP |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 17693063; 8722795; |
| Functional description | Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Essential component in the normal development of two neuronal crest-derived cell lineages. |
| Sequence | MQSPASRCGR ALVALLLACG FLGVWGEKRG FPPAQATLSL LGTKEVMTPP TKTSWTRGSN 60 SSLMRSSAPA EVTKGGRGAG VPPRSFPPPC QRNIEISKTF KYINTIVSCL VFVLGIIGNS 120 TLLRIIYKNK CMRNGPNILI ASLALGDLLH IIIDIPINTY KLLAEDWPFG AEMCKLVPFI 180 QKASVGITVL SLCALSIDRY RAVASWSRIK GIGVPKWTAV EIVLIWVVSV VLAVPEAIGF 240 DMITSDYKGK PLRVCMLNPF QKTAFMQFYK TAKDWWLFSF YFCLPLAITA VFYTLMTCEM 300 LRKKSGMQIA LNDHLKQRRE VAKTVFCLVL VFALCWLPLH LSRILKLTLY DQSNPHRCEL 360 LSFLLVLDYI GINMASLNSC INPIALYLVS KRFKNCFKSC LCCWCQTFEE KQSLEEKQSC 420 LKFKANDHGY DNFRSSNKYS SS 442 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | EDNRB | 281750 | P28088 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | EDNRB | 403862 | F1PB15 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | EDNRB | 102186699 | A0A452E880 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | EDNRB | 1910 | P24530 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Ednrb | 13618 | P48302 | CPO,CLP | Mus musculus | Publication | More>> | |
| 1:1 ortholog | EDNRB | 452613 | H2Q7N9 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | EDNRB | 414911 | P35463 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | EDNRB | 100009477 | D6CI21 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Ednrb | 50672 | P21451 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | ednrba | 30442 | Q9DGM2 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0004962 | endothelin receptor activity | ISO |
| GO:0004962 | endothelin receptor activity | IMP |
| GO:0004962 | endothelin receptor activity | IDA |
| GO:0005515 | protein binding | IPI |
| GO:0017046 | peptide hormone binding | ISO |
| GO:0031702 | type 1 angiotensin receptor binding | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | ISO |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA |
| GO:0001755 | neural crest cell migration | IMP |
| GO:0001934 | positive regulation of protein phosphorylation | ISO |
| GO:0006885 | regulation of pH | IMP |
| GO:0007186 | G protein-coupled receptor signaling pathway | IDA |
| GO:0007186 | G protein-coupled receptor signaling pathway | IGI |
| GO:0007200 | phospholipase C-activating G protein-coupled receptor signaling pathway | ISO |
| GO:0007204 | positive regulation of cytosolic calcium ion concentration | ISO |
| GO:0007422 | peripheral nervous system development | IMP |
| GO:0007497 | posterior midgut development | IMP |
| GO:0007568 | aging | IEA |
| GO:0008217 | regulation of blood pressure | ISO |
| GO:0008217 | regulation of blood pressure | IMP |
| GO:0008284 | positive regulation of cell population proliferation | ISO |
| GO:0014043 | negative regulation of neuron maturation | IDA |
| GO:0014070 | response to organic cyclic compound | IEA |
| GO:0014826 | vein smooth muscle contraction | ISO |
| GO:0019233 | sensory perception of pain | ISO |
| GO:0019722 | calcium-mediated signaling | ISS |
| GO:0019722 | calcium-mediated signaling | ISO |
| GO:0019934 | cGMP-mediated signaling | ISO |
| GO:0030318 | melanocyte differentiation | ISO |
| GO:0030318 | melanocyte differentiation | IMP |
| GO:0030318 | melanocyte differentiation | IDA |
| GO:0031620 | regulation of fever generation | ISO |
| GO:0032269 | negative regulation of cellular protein metabolic process | ISO |
| GO:0032496 | response to lipopolysaccharide | ISO |
| GO:0035645 | enteric smooth muscle cell differentiation | IDA |
| GO:0035810 | positive regulation of urine volume | ISO |
| GO:0035815 | positive regulation of renal sodium excretion | ISO |
| GO:0042045 | epithelial fluid transport | ISO |
| GO:0042310 | vasoconstriction | ISO |
| GO:0042311 | vasodilation | ISO |
| GO:0043066 | negative regulation of apoptotic process | ISO |
| GO:0043473 | pigmentation | ISO |
| GO:0043473 | pigmentation | IMP |
| GO:0048066 | developmental pigmentation | IMP |
| GO:0048246 | macrophage chemotaxis | ISO |
| GO:0048265 | response to pain | ISO |
| GO:0048484 | enteric nervous system development | ISO |
| GO:0048484 | enteric nervous system development | IDA |
| GO:0050678 | regulation of epithelial cell proliferation | ISO |
| GO:0051930 | regulation of sensory perception of pain | ISO |
| GO:0060406 | positive regulation of penile erection | ISO |
| GO:0071222 | cellular response to lipopolysaccharide | IEA |
| GO:0086100 | endothelin receptor signaling pathway | ISO |
| GO:1990839 | response to endothelin | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005623 | cell | IEA |
| GO:0005886 | plasma membrane | ISS |
| GO:0005886 | plasma membrane | ISO |
| GO:0016020 | membrane | ISO |
| GO:0016021 | integral component of membrane | IEA |
| GO:0031965 | nuclear membrane | ISO |
| GO:0045121 | membrane raft | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-372790 | Signaling by GPCR | IEA |
| R-MMU-373076 | Class A/1 (Rhodopsin-like receptors) | IEA |
| R-MMU-375276 | Peptide ligand-binding receptors | IEA |
| R-MMU-388396 | GPCR downstream signalling | IEA |
| R-MMU-416476 | G alpha (q) signalling events | IEA |
| R-MMU-500792 | GPCR ligand binding | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-1003 | Cell membrane |
| KW-1015 | Disulfide bond |
| KW-0297 | G-protein coupled receptor |
| KW-0325 | Glycoprotein |
| KW-0449 | Lipoprotein |
| KW-0472 | Membrane |
| KW-0564 | Palmitate |
| KW-0597 | Phosphoprotein |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0732 | Signal |
| KW-0807 | Transducer |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| Pfam ID | Pfam Term |
|---|---|
| PF00001 | 7tm_1 |