| Tag | Content |
|---|---|
| Uniprot ID | P28088; Q0VCB3; Q9TSB9; |
| Entrez ID | 281750 |
| Genbank protein ID | BAA01762.1; AAI20257.1; BAA14422.1; |
| Genbank nucleotide ID | NM_174309.2; XM_005213874.3; |
| Ensembl protein ID | ENSBTAP00000006979; ENSBTAP00000064163; |
| Ensembl nucleotide ID | ENSBTAG00000005299 |
| Gene name | Endothelin receptor type B |
| Gene symbol | EDNRB |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. |
| Sequence | MQPLPSLCGR ALVALILACG VAGIQAEERE FPPAGATQPL PGTGEMMETP TETSWPGRSN 60 ASDPRSSATP QIPRGGRMAG IPPRTPPPCD GPIEIKETFK YINTVVSCLV FVLGIIGNST 120 LLRIIYKNKC MRNGPNILIA SLALGDLLHI IIDIPINTYK LLAKDWPFGV EMCKLVPFIQ 180 KASVGITVLS LCALSIDRYR AVASWSRIKG IGVPKWTAVE IVLIWVVSVV LAVPEAVGFD 240 IITSDHIGNK LRICLLHPTQ KTAFMQFYKT AKDWWLFSFY FCLPLAITAL FYTLMTCEML 300 RKKSGMQIAL NDHLKQRREV AKTVFCLVLV FALCWLPLHL SRILKLTLYD QHDPRRCEFL 360 SFLLVLDYIG INMASLNSCI NPIALYLVSK RFKNCFKSCL CCWCQSFEEK QSLEEKQSCL 420 KFKANDHGYD NFRSSNKYSS S 441 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | EDNRB | 281750 | P28088 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | EDNRB | 403862 | F1PB15 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | EDNRB | 102186699 | A0A452E880 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | EDNRB | 1910 | P24530 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Ednrb | 13618 | P48302 | CPO,CLP | Mus musculus | Publication | More>> | |
| 1:1 ortholog | EDNRB | 452613 | H2Q7N9 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | EDNRB | 414911 | P35463 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | EDNRB | 100009477 | D6CI21 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Ednrb | 50672 | P21451 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | ednrba | 30442 | Q9DGM2 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0016021 | integral component of membrane |
| GO:0005886 | plasma membrane |
| GO:0004962 | endothelin receptor activity |
| GO:0017046 | peptide hormone binding |
| GO:0019722 | calcium-mediated signaling |
| GO:0086100 | endothelin receptor signaling pathway |
| GO:0048484 | enteric nervous system development |
| GO:0035645 | enteric smooth muscle cell differentiation |
| GO:0048246 | macrophage chemotaxis |
| GO:0030318 | melanocyte differentiation |
| GO:0032269 | negative regulation of cellular protein metabolic process |
| GO:0014043 | negative regulation of neuron maturation |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0001755 | neural crest cell migration |
| GO:0007422 | peripheral nervous system development |
| GO:0007497 | posterior midgut development |
| GO:0008217 | regulation of blood pressure |
| GO:0006885 | regulation of pH |
| GO:0014826 | vein smooth muscle contraction |
| Keyword ID | Keyword Term |
|---|---|
| KW-1003 | Cell membrane |
| KW-0903 | Direct protein sequencing |
| KW-1015 | Disulfide bond |
| KW-0297 | G-protein coupled receptor |
| KW-0449 | Lipoprotein |
| KW-0472 | Membrane |
| KW-0564 | Palmitate |
| KW-0597 | Phosphoprotein |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0732 | Signal |
| KW-0807 | Transducer |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| Pfam ID | Pfam Term |
|---|---|
| PF00001 | 7tm_1 |