| Tag | Content |
|---|---|
| Uniprot ID | P21451 |
| Entrez ID | 50672 |
| Genbank protein ID | AAB28172.1; CAA40916.1; |
| Genbank nucleotide ID | XM_017599786.1; XM_006252431.3; NM_017333.1; |
| Ensembl protein ID | ENSRNOP00000014747 |
| Ensembl nucleotide ID | ENSRNOG00000010997 |
| Gene name | Endothelin receptor type B |
| Gene symbol | Ednrb |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. |
| Sequence | MQSSASRCGR ALVALLLACG LLGVWGEKRG FPPAQATPSL LGTKEVMTPP TKTSWTRGSN 60 SSLMRSSAPA EVTKGGRVAG VPPRSFPPPC QRKIEINKTF KYINTIVSCL VFVLGIIGNS 120 TLLRIIYKNK CMRNGPNILI ASLALGDLLH IIIDIPINAY KLLAGDWPFG AEMCKLVPFI 180 QKASVGITVL SLCALSIDRY RAVASWSRIK GIGVPKWTAV EIVLIWVVSV VLAVPEAIGF 240 DVITSDYKGK PLRVCMLNPF QKTAFMQFYK TAKDWWLFSF YFCLPLAITA IFYTLMTCEM 300 LRKKSGMQIA LNDHLKQRRE VAKTVFCLVL VFALCWLPLH LSRILKLTLY DQSNPQRCEL 360 LSFLLVLDYI GINMASLNSC INPIALYLVS KRFKNCFKSC LCCWCQTFEE KQSLEEKQSC 420 LKFKANDHGY DNFRSSNKYS SS 442 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | EDNRB | 281750 | P28088 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | EDNRB | 403862 | F1PB15 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | EDNRB | 102186699 | A0A452E880 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | EDNRB | 1910 | P24530 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Ednrb | 13618 | P48302 | CPO,CLP | Mus musculus | Publication | More>> | |
| 1:1 ortholog | EDNRB | 452613 | H2Q7N9 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | EDNRB | 414911 | P35463 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | EDNRB | 100009477 | D6CI21 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Ednrb | 50672 | P21451 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | ednrba | 30442 | Q9DGM2 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005623 | cell |
| GO:0016021 | integral component of membrane |
| GO:0016020 | membrane |
| GO:0045121 | membrane raft |
| GO:0031965 | nuclear membrane |
| GO:0005886 | plasma membrane |
| GO:0004962 | endothelin receptor activity |
| GO:0004930 | G protein-coupled receptor activity |
| GO:0017046 | peptide hormone binding |
| GO:0038023 | signaling receptor activity |
| GO:0031702 | type 1 angiotensin receptor binding |
| GO:0007568 | aging |
| GO:0019722 | calcium-mediated signaling |
| GO:0071222 | cellular response to lipopolysaccharide |
| GO:0019934 | cGMP-mediated signaling |
| GO:0048066 | developmental pigmentation |
| GO:0086100 | endothelin receptor signaling pathway |
| GO:0048484 | enteric nervous system development |
| GO:0035645 | enteric smooth muscle cell differentiation |
| GO:0042045 | epithelial fluid transport |
| GO:0007186 | G protein-coupled receptor signaling pathway |
| GO:0048246 | macrophage chemotaxis |
| GO:0030318 | melanocyte differentiation |
| GO:0043066 | negative regulation of apoptotic process |
| GO:0032269 | negative regulation of cellular protein metabolic process |
| GO:0014043 | negative regulation of neuron maturation |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0001755 | neural crest cell migration |
| GO:0007422 | peripheral nervous system development |
| GO:0007200 | phospholipase C-activating G protein-coupled receptor signaling pathway |
| GO:0043473 | pigmentation |
| GO:0008284 | positive regulation of cell population proliferation |
| GO:0007204 | positive regulation of cytosolic calcium ion concentration |
| GO:0060406 | positive regulation of penile erection |
| GO:0001934 | positive regulation of protein phosphorylation |
| GO:0035815 | positive regulation of renal sodium excretion |
| GO:0035810 | positive regulation of urine volume |
| GO:0007497 | posterior midgut development |
| GO:0008217 | regulation of blood pressure |
| GO:0050678 | regulation of epithelial cell proliferation |
| GO:0031620 | regulation of fever generation |
| GO:0006885 | regulation of pH |
| GO:0051930 | regulation of sensory perception of pain |
| GO:1990839 | response to endothelin |
| GO:0032496 | response to lipopolysaccharide |
| GO:0014070 | response to organic cyclic compound |
| GO:0048265 | response to pain |
| GO:0019233 | sensory perception of pain |
| GO:0042310 | vasoconstriction |
| GO:0042311 | vasodilation |
| GO:0014826 | vein smooth muscle contraction |
| Keyword ID | Keyword Term |
|---|---|
| KW-1003 | Cell membrane |
| KW-1015 | Disulfide bond |
| KW-0297 | G-protein coupled receptor |
| KW-0325 | Glycoprotein |
| KW-0449 | Lipoprotein |
| KW-0472 | Membrane |
| KW-0564 | Palmitate |
| KW-0597 | Phosphoprotein |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0732 | Signal |
| KW-0807 | Transducer |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| Pfam ID | Pfam Term |
|---|---|
| PF00001 | 7tm_1 |