Gene: NECTIN2

Basic information

Tag Content
Uniprot ID F1PWL4
Entrez ID 611060
Genbank protein ID
Genbank nucleotide ID XM_847558.4
Ensembl protein ID ENSCAFP00000006905
Ensembl nucleotide ID ENSCAFG00000004626
Gene name Nectin cell adhesion molecule 2
Gene symbol NECTIN2
Organism Canis lupus familiaris
NCBI taxa ID 9615
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MARAAALPPS RSSPPLPLLP PLLLLLLLLR ETGAQDVQVR VPSEVRGYLG GTVQLPCHLL 60
PTGPEVRVSQ VTWLHVDATG ASRSVAAFHP SYGPSFRSPQ PGKERLSFVT AGQSTGTRQG 120
TEMELRDATL ALQGLTVEDE GNYTCEFATF PSGTSRGVTW LRAIAQPQNH AETQEVTLSL 180
DPVPVARCVS EGGRPPARIS WFSPLDGEAK ESQISGPVPG TVTVTSRFTL VPLSRVDGVK 240
VTCKVEHESF EEPILLPVTL SVRYPPEVSI SGYDDNWYLG RSEATLSCDV RSKPEPTGYD 300
WSTTAGVFPA SAVAQGPQLI IHSVDRLVNT TFICTVTNAV GTGRAEQVVL VRETPNTAGA 360
GATGGIIGGI IAAIIATAVV ATGILICRQQ RKEQRLQGAE EEDDLEGPPS YKPPAPKAKL 420
EEPEMPSQLF TLGPSEHSPL KTPYFDAGIP CAEQDMPRYH ELPTLEERSG PLLLGATGLG 480
PPMLVSPGPP AMEGVSLDLE DEEEEEDYID KISPIYDALS YSSPSDSYQS KGFVMSRAMY 540
V 541

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologNECTIN2505580Q17QC7Bos taurusPredictionMore>>
1:1 orthologNECTIN2611060F1PWL4Canis lupus familiarisPredictionMore>>
1:1 orthologNECTIN2A0A452G7Y9Capra hircusPredictionMore>>
1:1 orthologNECTIN2100065463F6YWH3Equus caballusPredictionMore>>
1:1 orthologNECTIN25819Q92692Homo sapiensPublicationMore>>
1:1 orthologNectin219294P32507Mus musculusPredictionMore>>
1:1 orthologNECTIN2456118K6ZRP3Pan troglodytesPredictionMore>>
1:1 orthologNECTIN2100038012A2TEQ2Sus scrofaPredictionMore>>
1:1 orthologNectin2308417A0A0G2KA71Rattus norvegicusPredictionMore>>

Gene ontology

GO ID GO Term
GO:0009986 cell surface
GO:0044291 cell-cell contact zone
GO:0016021 integral component of membrane
GO:0005886 plasma membrane
GO:0005915 zonula adherens
GO:0050839 cell adhesion molecule binding
GO:0042803 protein homodimerization activity
GO:0001675 acrosome assembly
GO:0032990 cell part morphogenesis
GO:0044782 cilium organization
GO:0046814 coreceptor-mediated virion attachment to host cell
GO:0007010 cytoskeleton organization
GO:0051654 establishment of mitochondrion localization
GO:0009566 fertilization
GO:0019064 fusion of virus membrane with host plasma membrane
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
GO:0002891 positive regulation of immunoglobulin mediated immune response
GO:0033005 positive regulation of mast cell activation
GO:0002860 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO:0050862 positive regulation of T cell receptor signaling pathway
GO:0046596 regulation of viral entry into host cell
GO:0030382 sperm mitochondrion organization
GO:0007289 spermatid nucleus differentiation
GO:0042271 susceptibility to natural killer cell mediated cytotoxicity
GO:0060370 susceptibility to T cell mediated cytotoxicity

Functional annotations

Keywords

Keyword ID Keyword Term
KW-1015 Disulfide bond
KW-0393 Immunoglobulin domain
KW-0472 Membrane
KW-1185 Reference proteome
KW-0732 Signal
KW-0812 Transmembrane
KW-1133 Transmembrane helix

Interpro

InterPro ID InterPro Term
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
IPR033318 Nectin-2

PROSITE

PROSITE ID PROSITE Term
PS50835 IG_LIKE

Pfam

Pfam ID Pfam Term
PF08205 C2-set_2
PF07686 V-set