| Tag | Content |
|---|---|
| Uniprot ID | P32507; Q62096; |
| Entrez ID | 19294 |
| Genbank protein ID | AAH59941.1; BAA05103.1; AAA39734.1; |
| Genbank nucleotide ID | NM_001159724.1; NM_008990.3; |
| Ensembl protein ID | ENSMUSP00000074898; ENSMUSP00000104089; |
| Ensembl nucleotide ID | ENSMUSG00000062300 |
| Gene name | Nectin-2 |
| Gene symbol | Nectin2 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive. Probable cell adhesion protein. |
| Sequence | MARAAVLPPS RLSPTLPLLP LLLLLLQETG AQDVRVRVLP EVRGRLGGTV ELPCHLLPPT 60 TERVSQVTWQ RLDGTVVAAF HPSFGVDFPN SQFSKDRLSF VRARPETNAD LRDATLAFRG 120 LRVEDEGNYT CEFATFPNGT RRGVTWLRVI AQPENHAEAQ EVTIGPQSVA VARCVSTGGR 180 PPARITWISS LGGEAKDTQE PGIQAGTVTI ISRYSLVPVG RADGVKVTCR VEHESFEEPI 240 LLPVTLSVRY PPEVSISGYD DNWYLGRSEA ILTCDVRSNP EPTDYDWSTT SGVFPASAVA 300 QGSQLLVHSV DRMVNTTFIC TATNAVGTGR AEQVILVRES PSTAGAGATG GIIGGIIAAI 360 IATAVAGTGI LICRQQRKEQ RLQAADEEEE LEGPPSYKPP TPKAKLEEPE MPSQLFTLGA 420 SEHSPVKTPY FDAGVSCADQ EMPRYHELPT LEERSGPLLL GATGLGPSLL VPPGPNVVEG 480 VSLSLEDEEE DDEEEDFLDK INPIYDALSY PSPSDSYQSK DFFVSRAMYV |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | NECTIN2 | 505580 | Q17QC7 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | NECTIN2 | 611060 | F1PWL4 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | NECTIN2 | A0A452G7Y9 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | NECTIN2 | 100065463 | F6YWH3 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | NECTIN2 | 5819 | Q92692 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Nectin2 | 19294 | P32507 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | NECTIN2 | 456118 | K6ZRP3 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | NECTIN2 | 100038012 | A2TEQ2 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Nectin2 | 308417 | A0A0G2KA71 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005515 | protein binding | IPI |
| GO:0042802 | identical protein binding | ISO |
| GO:0042803 | protein homodimerization activity | ISO |
| GO:0042803 | protein homodimerization activity | IDA |
| GO:0050839 | cell adhesion molecule binding | ISO |
| GO:0050839 | cell adhesion molecule binding | IPI |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001675 | acrosome assembly | IMP |
| GO:0002860 | positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target | ISO |
| GO:0002891 | positive regulation of immunoglobulin mediated immune response | ISO |
| GO:0007010 | cytoskeleton organization | IMP |
| GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules | ISO |
| GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules | IDA |
| GO:0007286 | spermatid development | IMP |
| GO:0007289 | spermatid nucleus differentiation | IMP |
| GO:0009566 | fertilization | IMP |
| GO:0019064 | fusion of virus membrane with host plasma membrane | ISO |
| GO:0030382 | sperm mitochondrion organization | IMP |
| GO:0032990 | cell part morphogenesis | IMP |
| GO:0033005 | positive regulation of mast cell activation | ISO |
| GO:0042271 | susceptibility to natural killer cell mediated cytotoxicity | ISO |
| GO:0044406 | adhesion of symbiont to host | ISO |
| GO:0044782 | cilium organization | IMP |
| GO:0045954 | positive regulation of natural killer cell mediated cytotoxicity | ISO |
| GO:0046596 | regulation of viral entry into host cell | ISO |
| GO:0046814 | coreceptor-mediated virion attachment to host cell | ISO |
| GO:0050862 | positive regulation of T cell receptor signaling pathway | ISO |
| GO:0051654 | establishment of mitochondrion localization | IMP |
| GO:0060370 | susceptibility to T cell mediated cytotoxicity | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005886 | plasma membrane | IDA |
| GO:0005911 | cell-cell junction | ISO |
| GO:0005911 | cell-cell junction | IDA |
| GO:0005915 | zonula adherens | IDA |
| GO:0009986 | cell surface | ISO |
| GO:0016021 | integral component of membrane | ISO |
| GO:0043296 | apical junction complex | IDA |
| GO:0044291 | cell-cell contact zone | IDA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-1280218 | Adaptive Immune System | IEA |
| R-MMU-1500931 | Cell-Cell communication | IEA |
| R-MMU-168256 | Immune System | IEA |
| R-MMU-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | IEA |
| R-MMU-418990 | Adherens junctions interactions | IEA |
| R-MMU-420597 | Nectin/Necl trans heterodimerization | IEA |
| R-MMU-421270 | Cell-cell junction organization | IEA |
| R-MMU-446728 | Cell junction organization | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-0002 | 3D-structure |
| KW-0025 | Alternative splicing |
| KW-0130 | Cell adhesion |
| KW-1003 | Cell membrane |
| KW-1015 | Disulfide bond |
| KW-0325 | Glycoprotein |
| KW-0393 | Immunoglobulin domain |
| KW-0472 | Membrane |
| KW-0597 | Phosphoprotein |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0732 | Signal |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| PROSITE ID | PROSITE Term |
|---|---|
| PS50835 | IG_LIKE |