Gene: NECTIN2

Basic information

Tag Content
Uniprot ID Q17QC7; F1MTV8;
Entrez ID 505580
Genbank protein ID AAI18435.1
Genbank nucleotide ID NM_001075210.2
Ensembl protein ID ENSBTAP00000020364
Ensembl nucleotide ID ENSBTAG00000015318
Gene name Nectin cell adhesion molecule 2
Gene symbol NECTIN2
Organism Bos taurus
NCBI taxa ID 9913
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MARAAALRPL RLSPPTLPLL PLLLLLLRET GAQDVRVQVA AEVRGNLGDT VELPCHLLPS 60
APEIRVSQVT WLRLDAPEGK QNVAIFHPQY GRSFPSPKPG KERLSFVNTA PSSGAGQGSE 120
LEVRDATLSL RGLTVEDEGN YTCEFATFPK GTSRGVTWLR VIAQPQNHAE KQEVTFNLDP 180
VPVARCVSAG GRPPARVSWL SPLDGEAKET QGSGPLPGTV TVTSRYTVTP LSEADGVKVI 240
CKVEHESFQE PKLLPVILSV RYPPQVSISG YDDNWYIGRS EATLNCNVRS KPEPTGYDWS 300
TTSGVFPASA VAQGPKLIVH SVDRLFNTTF ICTVTNAVGT GQAEQVVLVR GDAGDLSTPE 360
SGRFPGGGNG SPLQYSSPEN PMDRGAWQAA VHAVAESKIW LSD 403

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologNECTIN2505580Q17QC7Bos taurusPredictionMore>>
1:1 orthologNECTIN2611060F1PWL4Canis lupus familiarisPredictionMore>>
1:1 orthologNECTIN2A0A452G7Y9Capra hircusPredictionMore>>
1:1 orthologNECTIN2100065463F6YWH3Equus caballusPredictionMore>>
1:1 orthologNECTIN25819Q92692Homo sapiensPublicationMore>>
1:1 orthologNectin219294P32507Mus musculusPredictionMore>>
1:1 orthologNECTIN2456118K6ZRP3Pan troglodytesPredictionMore>>
1:1 orthologNECTIN2100038012A2TEQ2Sus scrofaPredictionMore>>
1:1 orthologNectin2308417A0A0G2KA71Rattus norvegicusPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005912 adherens junction
GO:0016021 integral component of membrane
GO:0050839 cell adhesion molecule binding
GO:0042803 protein homodimerization activity
GO:0038023 signaling receptor activity
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
GO:0002860 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO:0042271 susceptibility to natural killer cell mediated cytotoxicity
GO:0060370 susceptibility to T cell mediated cytotoxicity

Functional annotations

Keywords

Keyword ID Keyword Term
KW-1015 Disulfide bond
KW-0393 Immunoglobulin domain
KW-0472 Membrane
KW-0675 Receptor
KW-1185 Reference proteome
KW-0732 Signal
KW-0812 Transmembrane
KW-1133 Transmembrane helix

Interpro

InterPro ID InterPro Term
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set

PROSITE

PROSITE ID PROSITE Term
PS50835 IG_LIKE

Pfam

Pfam ID Pfam Term
PF08205 C2-set_2
PF07686 V-set