| Tag | Content |
|---|---|
| Uniprot ID | F1QU39 |
| Entrez ID | 335098 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_005160285.3 |
| Ensembl protein ID | ENSDARP00000052422; ENSDARP00000151098; |
| Ensembl nucleotide ID | ENSDARG00000078308 |
| Gene name | Protein sprouty homolog 2 |
| Gene symbol | spry2 |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | METRTQNGGS GSSGLLRALR DSGRPQTGDS EPWDGQVLSL DQIRTIRGSN EYTEGPTVAP 60 RPPASEQKTD SQASSPTSTS SIELPEHRNS LRAQQAGQQT PQQAPRGGVS RSISGTSDGS 120 HSTTRASTGS TSSDQRLLGN AGDRVVRVQP KRSEQKQEEL KPLSAPVGPA PDGKHSVLCE 180 DCGRCKCEGC TCPRTLPSCW MCGRRCVCSA TSAMDYVTCV CCVKCLFYHC SSDDEDVCAD 240 KPFSCTQSHC CMRWSAISVL ALFLPCLLCY LPAKGCVALC QACYDCTSRP GCRCKNKGVE 300 K 301 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SPRY2 | 539090 | Q08E39 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | SPRY2 | 485504 | E2RGU9 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | SPRY2 | 102188779 | A0A452DWT1 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | SPRY2 | F6UL06 | Equus caballus | Prediction | More>> | |||
| 1:1 ortholog | SPRY2 | 10253 | O43597 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Spry2 | 24064 | Q9QXV8 | CPO | E13.5, E14.5, E16.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | SPRY2 | H2Q7P2 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | SPRY2 | 100157266 | F1RP67 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | SPRY2 | 100352158 | G1SXJ1 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Spry2 | 306141 | Q5HZA2 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | spry2 | 335098 | F1QU39 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005829 | cytosol |
| GO:0016020 | membrane |
| GO:0001525 | angiogenesis |
| GO:0048513 | animal organ development |
| GO:0009953 | dorsal/ventral pattern formation |
| GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
| GO:0040037 | negative regulation of fibroblast growth factor receptor signaling pathway |
| GO:0043407 | negative regulation of MAP kinase activity |
| GO:0046580 | negative regulation of Ras protein signal transduction |
| GO:0045595 | regulation of cell differentiation |
| GO:0042127 | regulation of cell population proliferation |
| GO:0060841 | venous blood vessel development |
| PROSITE ID | PROSITE Term |
|---|---|
| PS51227 | SPR |
| Pfam ID | Pfam Term |
|---|---|
| PF05210 | Sprouty |