| Tag | Content |
|---|---|
| Uniprot ID | Q9QXV8; Q9WUQ9; |
| Entrez ID | 24064 |
| Genbank protein ID | AAD56006.1; AAD34167.1; |
| Genbank nucleotide ID | XM_006519016.3; NM_011897.3; |
| Ensembl protein ID | ENSMUSP00000022709 |
| Ensembl nucleotide ID | ENSMUSG00000022114 |
| Gene name | Protein sprouty homolog 2 |
| Gene symbol | Spry2 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | E13.5, E14.5, E16.5 |
| Data sources | Manually collected |
| Reference | 17693063; 21195053; 22674535; |
| Functional description | Antagonist of fibroblast growth factor (FGF) pathways via inhibition of FGF-mediated phosphorylation of ERK1/2 (PubMed:29501879). Thereby acts as an antagonist of FGF-induced retinal lens fiber differentiation, may inhibit limb bud outgrowth and may negatively modulate respiratory organogenesis (PubMed:10498682, PubMed:10074434, PubMed:29501879). Inhibits TGFB-induced epithelial-to-mesenchymal transition in retinal lens epithelial cells (PubMed:25576668). |
| Sequence | MEARAQSGNG SQPLLQTAHD SGRQRGEPDP RDALTQQVHV LSLDQIRAIR NTNEYTEGPT 60 VVPRPGLKPA PRPSTQHKHE RLHGLPEHRQ PPRLQPSQVH SSRAPLSRSI STVSSGSRSS 120 TRTSTSSSSS EQRLLGPSFS HGPAAADGII RVQPKSELKP GDVKPLSKDD LGLHAYRCED 180 CGKCKCKECT YPRPLPSDWI CDKQCLCSAQ NVIDYGTCVC CVKGLFYHCS NDDEDNCADN 240 PCSCSQSHCC TRWSAMGVMS LFLPCLWCYL PAKGCLKLCQ GCYDRVNRPG CRCKNSNTVC 300 CKVPTVPPRN FEKPT 315 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SPRY2 | 539090 | Q08E39 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | SPRY2 | 485504 | E2RGU9 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | SPRY2 | 102188779 | A0A452DWT1 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | SPRY2 | F6UL06 | Equus caballus | Prediction | More>> | |||
| 1:1 ortholog | SPRY2 | 10253 | O43597 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Spry2 | 24064 | Q9QXV8 | CPO | E13.5, E14.5, E16.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | SPRY2 | H2Q7P2 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | SPRY2 | 100157266 | F1RP67 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | SPRY2 | 100352158 | G1SXJ1 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Spry2 | 306141 | Q5HZA2 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | spry2 | 335098 | F1QU39 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005515 | protein binding | IPI |
| GO:0019901 | protein kinase binding | ISO |
| GO:0043539 | protein serine/threonine kinase activator activity | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000132 | establishment of mitotic spindle orientation | IGI |
| GO:0007605 | sensory perception of sound | IMP |
| GO:0008285 | negative regulation of cell population proliferation | IDA |
| GO:0010628 | positive regulation of gene expression | ISO |
| GO:0010801 | negative regulation of peptidyl-threonine phosphorylation | ISO |
| GO:0016525 | negative regulation of angiogenesis | ISO |
| GO:0030324 | lung development | IMP |
| GO:0030335 | positive regulation of cell migration | ISO |
| GO:0031345 | negative regulation of cell projection organization | IDA |
| GO:0033138 | positive regulation of peptidyl-serine phosphorylation | ISO |
| GO:0034260 | negative regulation of GTPase activity | IDA |
| GO:0035924 | cellular response to vascular endothelial growth factor stimulus | ISO |
| GO:0040037 | negative regulation of fibroblast growth factor receptor signaling pathway | IDA |
| GO:0040037 | negative regulation of fibroblast growth factor receptor signaling pathway | IGI |
| GO:0040037 | negative regulation of fibroblast growth factor receptor signaling pathway | IBA |
| GO:0042472 | inner ear morphogenesis | IGI |
| GO:0042472 | inner ear morphogenesis | IMP |
| GO:0043066 | negative regulation of apoptotic process | ISO |
| GO:0043066 | negative regulation of apoptotic process | IMP |
| GO:0043407 | negative regulation of MAP kinase activity | IDA |
| GO:0043407 | negative regulation of MAP kinase activity | IBA |
| GO:0045165 | cell fate commitment | IGI |
| GO:0045165 | cell fate commitment | IMP |
| GO:0045595 | regulation of cell differentiation | IEA |
| GO:0046580 | negative regulation of Ras protein signal transduction | IDA |
| GO:0046580 | negative regulation of Ras protein signal transduction | IBA |
| GO:0048513 | animal organ development | IBA |
| GO:0048754 | branching morphogenesis of an epithelial tube | IMP |
| GO:0051387 | negative regulation of neurotrophin TRK receptor signaling pathway | IDA |
| GO:0051897 | positive regulation of protein kinase B signaling | ISO |
| GO:0060425 | lung morphogenesis | IDA |
| GO:0060437 | lung growth | IDA |
| GO:0060449 | bud elongation involved in lung branching | IGI |
| GO:0060541 | respiratory system development | IDA |
| GO:0070373 | negative regulation of ERK1 and ERK2 cascade | ISO |
| GO:0070373 | negative regulation of ERK1 and ERK2 cascade | IDA |
| GO:0070373 | negative regulation of ERK1 and ERK2 cascade | IGI |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade | ISO |
| GO:0071902 | positive regulation of protein serine/threonine kinase activity | IEA |
| GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway | ISO |
| GO:1990830 | cellular response to leukemia inhibitory factor | IEP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005623 | cell | IEA |
| GO:0005634 | nucleus | IDA |
| GO:0005829 | cytosol | IDA |
| GO:0005829 | cytosol | IBA |
| GO:0005856 | cytoskeleton | IDA |
| GO:0015629 | actin cytoskeleton | ISO |
| GO:0015630 | microtubule cytoskeleton | ISO |
| GO:0016020 | membrane | IDA |
| GO:0032587 | ruffle membrane | IEA |
| GO:1990752 | microtubule end | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-1295596 | Spry regulation of FGF signaling | IEA |
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-177929 | Signaling by EGFR | IEA |
| R-MMU-182971 | EGFR downregulation | IEA |
| R-MMU-190236 | Signaling by FGFR | IEA |
| R-MMU-5654726 | Negative regulation of FGFR1 signaling | IEA |
| R-MMU-5654727 | Negative regulation of FGFR2 signaling | IEA |
| R-MMU-5654732 | Negative regulation of FGFR3 signaling | IEA |
| R-MMU-5654733 | Negative regulation of FGFR4 signaling | IEA |
| R-MMU-5654736 | Signaling by FGFR1 | IEA |
| R-MMU-5654738 | Signaling by FGFR2 | IEA |
| R-MMU-5654741 | Signaling by FGFR3 | IEA |
| R-MMU-5654743 | Signaling by FGFR4 | IEA |
| R-MMU-9006934 | Signaling by Receptor Tyrosine Kinases | IEA |
| PROSITE ID | PROSITE Term |
|---|---|
| PS51227 | SPR |
| Pfam ID | Pfam Term |
|---|---|
| PF05210 | Sprouty |