Gene: SPRY2

Basic information

Tag Content
Uniprot ID H2Q7P2
Entrez ID
Genbank protein ID
Genbank nucleotide ID
Ensembl protein ID ENSPTRP00000010120
Ensembl nucleotide ID ENSPTRG00000005951
Gene name Sprouty RTK signaling antagonist 2
Gene symbol SPRY2
Organism Pan troglodytes
NCBI taxa ID 9598
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MEARAQSGNG SQPLLQTPRD GGRQRGEPDP RDALTQQVHV LSLDQIRAIR NTNEYTEGPT 60
VVPRPGLKPA PRPSTQHKHE RLHGLPEHRQ PPRLQHSQVH SSARAPLSRS ISTVSSGSRS 120
STRTSTSSSS SEQRLLGSSF SSGPVADGII RVQPKSELKP GELKPLSKED LGLHAYRCED 180
CGKCKCKECT YPRPLPSDWI CDKQCLCSAQ NVIDYGTCVC CVKGLFYHCS NDDEDNCADN 240
PCSCSQSHCC TRWSAMGVMS LFLPCLWCYL PAKGCLKLCQ GCYDRVNRPG CRCKNSNTVC 300
CKVPTEYYSN EDFFFLFLIH ICNQLNSYNL GTVNRKLG 338

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologSPRY2539090Q08E39Bos taurusPredictionMore>>
1:1 orthologSPRY2485504E2RGU9Canis lupus familiarisPredictionMore>>
1:1 orthologSPRY2102188779A0A452DWT1Capra hircusPredictionMore>>
1:1 orthologSPRY2F6UL06Equus caballusPredictionMore>>
1:1 orthologSPRY210253O43597Homo sapiensPredictionMore>>
1:1 orthologSpry224064Q9QXV8CPOE13.5, E14.5, E16.5Mus musculusPublicationMore>>
1:1 orthologSPRY2H2Q7P2Pan troglodytesPredictionMore>>
1:1 orthologSPRY2100157266F1RP67Sus scrofaPredictionMore>>
1:1 orthologSPRY2100352158G1SXJ1Oryctolagus cuniculusPredictionMore>>
1:1 orthologSpry2306141Q5HZA2Rattus norvegicusPredictionMore>>
1:1 orthologspry2335098F1QU39Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0015629 actin cytoskeleton
GO:0005623 cell
GO:0005829 cytosol
GO:0016020 membrane
GO:1990752 microtubule end
GO:0005634 nucleus
GO:0019901 protein kinase binding
GO:0043539 protein serine/threonine kinase activator activity
GO:0048513 animal organ development
GO:0060449 bud elongation involved in lung branching
GO:0045165 cell fate commitment
GO:1990830 cellular response to leukemia inhibitory factor
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0000132 establishment of mitotic spindle orientation
GO:0042472 inner ear morphogenesis
GO:0060437 lung growth
GO:0016525 negative regulation of angiogenesis
GO:0043066 negative regulation of apoptotic process
GO:0008285 negative regulation of cell population proliferation
GO:0031345 negative regulation of cell projection organization
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway
GO:0034260 negative regulation of GTPase activity
GO:0043407 negative regulation of MAP kinase activity
GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway
GO:0010801 negative regulation of peptidyl-threonine phosphorylation
GO:0046580 negative regulation of Ras protein signal transduction
GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway
GO:0030335 positive regulation of cell migration
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0010628 positive regulation of gene expression
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0051897 positive regulation of protein kinase B signaling
GO:0045595 regulation of cell differentiation
GO:0007605 sensory perception of sound

Functional annotations

Keywords

Keyword ID Keyword Term
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR007875 Sprouty
IPR030780 SPRY2

PROSITE

PROSITE ID PROSITE Term
PS51227 SPR

Pfam

Pfam ID Pfam Term
PF05210 Sprouty