| Tag | Content |
|---|---|
| Uniprot ID | F1RP67 |
| Entrez ID | 100157266 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_001927097.4 |
| Ensembl protein ID | ENSSSCP00000010127; ENSSSCP00000069477; |
| Ensembl nucleotide ID | ENSSSCG00000009482 |
| Gene name | Sprouty RTK signaling antagonist 2 |
| Gene symbol | SPRY2 |
| Organism | Sus scrofa |
| NCBI taxa ID | 9823 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MEARAQSGSG SQPLLQAPRD GGRQRGEPDP RDALTQQVHV LSLDQIRAIR NTNEYTEGPT 60 VVPRPGLKPA PRPSAQHKHE RLNGLPEHRQ PPRLQHSQAH VSVRASLSRS ISTVSSGSRS 120 STRTSTSSNS SEQRLLGSSF SSGPVADGII RVQPKSELKP GELKPLSKED LGLHAYRCED 180 CGKCKCKECT YPRPLPSDWI CDKQCLCSAQ NVIDYGTCVC CVKGLFYHCS NDDEDNCADN 240 PCSCSQSHCC TRWSAMGVMS LFLPCLWCYL PAKGCLKLCQ GCYDRVNRPG CRCKNSNTVC 300 CRVPTVPPRN FEKPT 315 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SPRY2 | 539090 | Q08E39 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | SPRY2 | 485504 | E2RGU9 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | SPRY2 | 102188779 | A0A452DWT1 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | SPRY2 | F6UL06 | Equus caballus | Prediction | More>> | |||
| 1:1 ortholog | SPRY2 | 10253 | O43597 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Spry2 | 24064 | Q9QXV8 | CPO | E13.5, E14.5, E16.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | SPRY2 | H2Q7P2 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | SPRY2 | 100157266 | F1RP67 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | SPRY2 | 100352158 | G1SXJ1 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Spry2 | 306141 | Q5HZA2 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | spry2 | 335098 | F1QU39 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005829 | cytosol |
| GO:0016020 | membrane |
| GO:0048513 | animal organ development |
| GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
| GO:0040037 | negative regulation of fibroblast growth factor receptor signaling pathway |
| GO:0043407 | negative regulation of MAP kinase activity |
| GO:0046580 | negative regulation of Ras protein signal transduction |
| GO:0045595 | regulation of cell differentiation |
| GO:0042127 | regulation of cell population proliferation |
| Keyword ID | Keyword Term |
|---|---|
| KW-1185 | Reference proteome |
| PROSITE ID | PROSITE Term |
|---|---|
| PS51227 | SPR |
| Pfam ID | Pfam Term |
|---|---|
| PF05210 | Sprouty |