| Tag | Content |
|---|---|
| Uniprot ID | Q5HZA2 |
| Entrez ID | 306141 |
| Genbank protein ID | AAH89116.1 |
| Genbank nucleotide ID | XM_006252438.3; NM_001012046.1; |
| Ensembl protein ID | ENSRNOP00000013342 |
| Ensembl nucleotide ID | ENSRNOG00000010058 |
| Gene name | Sprouty RTK-signaling antagonist 2 |
| Gene symbol | Spry2 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MEARAQSGSG SQPLLQSPHD SGRQRGEPDP RDALTQQVHV LSLDQIRAIR NTNEYTEGPT 60 VVPRPGLKPA PRPSTQHKHE RLHGLPEHRQ PPRLQPTQVH SSRAALSRSV STVSSGSRSS 120 TRTSTSSSSS EQRLLGSSFS PGPAVDGIIR VQPKSELKSG ELKPLSRDDL GLHAYRCEDC 180 GKCKCKECTY PRPLPSDWIC DKQCLCSAQN VIDYGTCVCC VKGLFYHCSN DDEDNCADNP 240 CSCSQSHCCT RWSAMGVMSL FLPCLWCYLP AKGCLKLCQG CYDRVNRPGC RCKNSNTVCC 300 KVPTVPPRNF EKPT 314 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SPRY2 | 539090 | Q08E39 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | SPRY2 | 485504 | E2RGU9 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | SPRY2 | 102188779 | A0A452DWT1 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | SPRY2 | F6UL06 | Equus caballus | Prediction | More>> | |||
| 1:1 ortholog | SPRY2 | 10253 | O43597 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Spry2 | 24064 | Q9QXV8 | CPO | E13.5, E14.5, E16.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | SPRY2 | H2Q7P2 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | SPRY2 | 100157266 | F1RP67 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | SPRY2 | 100352158 | G1SXJ1 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Spry2 | 306141 | Q5HZA2 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | spry2 | 335098 | F1QU39 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0015629 | actin cytoskeleton |
| GO:0005623 | cell |
| GO:0005856 | cytoskeleton |
| GO:0005829 | cytosol |
| GO:0016020 | membrane |
| GO:1990752 | microtubule end |
| GO:0005634 | nucleus |
| GO:0019901 | protein kinase binding |
| GO:0043539 | protein serine/threonine kinase activator activity |
| GO:0048513 | animal organ development |
| GO:0048754 | branching morphogenesis of an epithelial tube |
| GO:0060449 | bud elongation involved in lung branching |
| GO:0045165 | cell fate commitment |
| GO:1990830 | cellular response to leukemia inhibitory factor |
| GO:0035924 | cellular response to vascular endothelial growth factor stimulus |
| GO:0000132 | establishment of mitotic spindle orientation |
| GO:0042472 | inner ear morphogenesis |
| GO:0030324 | lung development |
| GO:0060437 | lung growth |
| GO:0060425 | lung morphogenesis |
| GO:0016525 | negative regulation of angiogenesis |
| GO:0043066 | negative regulation of apoptotic process |
| GO:0008285 | negative regulation of cell population proliferation |
| GO:0031345 | negative regulation of cell projection organization |
| GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
| GO:0040037 | negative regulation of fibroblast growth factor receptor signaling pathway |
| GO:0034260 | negative regulation of GTPase activity |
| GO:0043407 | negative regulation of MAP kinase activity |
| GO:0051387 | negative regulation of neurotrophin TRK receptor signaling pathway |
| GO:0010801 | negative regulation of peptidyl-threonine phosphorylation |
| GO:0046580 | negative regulation of Ras protein signal transduction |
| GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway |
| GO:0030335 | positive regulation of cell migration |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| GO:0010628 | positive regulation of gene expression |
| GO:0033138 | positive regulation of peptidyl-serine phosphorylation |
| GO:0051897 | positive regulation of protein kinase B signaling |
| GO:0045595 | regulation of cell differentiation |
| GO:0060541 | respiratory system development |
| GO:0007605 | sensory perception of sound |
| Keyword ID | Keyword Term |
|---|---|
| KW-1185 | Reference proteome |
| PROSITE ID | PROSITE Term |
|---|---|
| PS51227 | SPR |
| Pfam ID | Pfam Term |
|---|---|
| PF05210 | Sprouty |