| Tag | Content |
|---|---|
| Uniprot ID | Q08E39 |
| Entrez ID | 539090 |
| Genbank protein ID | AAI23436.1 |
| Genbank nucleotide ID | XM_005213881.3; NM_001076147.1; |
| Ensembl protein ID | ENSBTAP00000043748 |
| Ensembl nucleotide ID | ENSBTAG00000001774 |
| Gene name | Protein sprouty homolog 2 |
| Gene symbol | SPRY2 |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Antagonist of fibroblast growth factor (FGF) pathways via inhibition of FGF-mediated phosphorylation of ERK1/2 (By similarity). Thereby acts as an antagonist of FGF-induced retinal lens fiber differentiation, may inhibit limb bud outgrowth and may negatively modulate respiratory organogenesis (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in retinal lens epithelial cells (By similarity). |
| Sequence | MEARAQSGSG SQPLLQAPRD SGRQRGEPDP RDALPQQVHV LSLDQIRAIR NTNEYTEGPT 60 VLPRAGLKPA PRPTAQHKHE RLHGLPEPRQ PSRPQHPPAH PSARASLARS ISTVSSGSRS 120 STRTSTSSSS SEQRLLGSSF SSGPLADRII RVQPKSELKP GELKPLSKED VGLHAYKCED 180 CGKCKCKECT YPRPLPSDWI CDKQCLCSAQ NVIDYGTCVC CVKGLFYHCS NDDEDNCADN 240 PCSCSQSHCC TRWSAMGVMS LFLPCLWCYL PAKGCLKLCQ GCYDRVNRPG CRCKNSNTVC 300 CKVPTVPPRN FEKPT 315 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SPRY2 | 539090 | Q08E39 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | SPRY2 | 485504 | E2RGU9 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | SPRY2 | 102188779 | A0A452DWT1 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | SPRY2 | F6UL06 | Equus caballus | Prediction | More>> | |||
| 1:1 ortholog | SPRY2 | 10253 | O43597 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Spry2 | 24064 | Q9QXV8 | CPO | E13.5, E14.5, E16.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | SPRY2 | H2Q7P2 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | SPRY2 | 100157266 | F1RP67 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | SPRY2 | 100352158 | G1SXJ1 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Spry2 | 306141 | Q5HZA2 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | spry2 | 335098 | F1QU39 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0015629 | actin cytoskeleton |
| GO:0005623 | cell |
| GO:0005829 | cytosol |
| GO:1990752 | microtubule end |
| GO:0005634 | nucleus |
| GO:0032587 | ruffle membrane |
| GO:0019901 | protein kinase binding |
| GO:0043539 | protein serine/threonine kinase activator activity |
| GO:0048513 | animal organ development |
| GO:0060449 | bud elongation involved in lung branching |
| GO:0045165 | cell fate commitment |
| GO:1990830 | cellular response to leukemia inhibitory factor |
| GO:0035924 | cellular response to vascular endothelial growth factor stimulus |
| GO:0000132 | establishment of mitotic spindle orientation |
| GO:0042472 | inner ear morphogenesis |
| GO:0060437 | lung growth |
| GO:0016525 | negative regulation of angiogenesis |
| GO:0043066 | negative regulation of apoptotic process |
| GO:0008285 | negative regulation of cell population proliferation |
| GO:0031345 | negative regulation of cell projection organization |
| GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
| GO:0040037 | negative regulation of fibroblast growth factor receptor signaling pathway |
| GO:0034260 | negative regulation of GTPase activity |
| GO:0043407 | negative regulation of MAP kinase activity |
| GO:0051387 | negative regulation of neurotrophin TRK receptor signaling pathway |
| GO:0010801 | negative regulation of peptidyl-threonine phosphorylation |
| GO:0046580 | negative regulation of Ras protein signal transduction |
| GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway |
| GO:0030335 | positive regulation of cell migration |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| GO:0010628 | positive regulation of gene expression |
| GO:0033138 | positive regulation of peptidyl-serine phosphorylation |
| GO:0051897 | positive regulation of protein kinase B signaling |
| GO:0045595 | regulation of cell differentiation |
| GO:0007605 | sensory perception of sound |
| PROSITE ID | PROSITE Term |
|---|---|
| PS51227 | SPR |
| Pfam ID | Pfam Term |
|---|---|
| PF05210 | Sprouty |