Gene: TYMS

Basic information

Tag Content
Uniprot ID F6TRC0
Entrez ID 100060971
Genbank protein ID
Genbank nucleotide ID XM_001492225.4
Ensembl protein ID ENSECAP00000020764
Ensembl nucleotide ID ENSECAG00000023203
Gene name Thymidylate synthetase
Gene symbol TYMS
Organism Equus caballus
NCBI taxa ID 9796
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MPAFGSELQR PPSPPAARER GSEPRPHGEL QYLGQIEHIL RSGFRKEDRT GTGTLSVFGL 60
QARYNLRDEF PLLTTKRVFW KGVLEELLWF IKGSTNANEL SCKGVKIWDA NGSRDFLDSL 120
GFSAREEGDL GPVYGFQWRH FGAEYKDMDS DYSGQGVDQL QKVINTIKTN PDDRRIILCA 180
WNPKDLPLMA LPPCHALCQF YVVNGELSCQ LYQRSGDMGL GVPFNIASYA LLTYMIAHIT 240
GLKPGDFVHT LGDAHIYLNH IDPLKTQLQR EPRPFPKLKI LRKVETIDDF KAEDFQLEGY 300
HPHPTIRMEM AV 312

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologTYMSF1MY63Bos taurusPredictionMore>>
1:1 orthologTYMSA0A452DJS6Capra hircusPredictionMore>>
1:1 orthologTYMS100060971F6TRC0Equus caballusPredictionMore>>
1:1 orthologTYMS7298P04818CPO,CL/PHomo sapiensPublicationMore>>
1:1 orthologTyms22171P07607E14.5Mus musculusPredictionMore>>
1:1 orthologTYMS740018G2HEY4Pan troglodytesPredictionMore>>
1:1 orthologTYMSA0A287AFN2Sus scrofaPredictionMore>>
1:1 orthologTYMS100347408G1SVL8Oryctolagus cuniculusPredictionMore>>
1:1 orthologTyms29261P45352Rattus norvegicusPredictionMore>>
1:1 orthologtyms81540Q6P045Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005829 cytosol
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
GO:0005739 mitochondrion
GO:0005634 nucleus
GO:1990825 sequence-specific mRNA binding
GO:0004799 thymidylate synthase activity
GO:0000900 translation repressor activity, mRNA regulatory element binding
GO:0006231 dTMP biosynthetic process
GO:0046683 response to organophosphorus
GO:0035999 tetrahydrofolate interconversion

Functional annotations

Keywords

Keyword ID Keyword Term
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR023451 Thymidate_synth/dCMP_Mease
IPR036926 Thymidate_synth/dCMP_Mease_sf
IPR000398 Thymidylate_synthase
IPR020940 Thymidylate_synthase_AS

PROSITE

PROSITE ID PROSITE Term
PS00091 THYMIDYLATE_SYNTHASE

Pfam

Pfam ID Pfam Term
PF00303 Thymidylat_synt