| Tag | Content |
|---|---|
| Uniprot ID | P45352; A0JN23; |
| Entrez ID | 29261 |
| Genbank protein ID | AAI26094.1; AAA92340.1; |
| Genbank nucleotide ID | NM_019179.1 |
| Ensembl protein ID | ENSRNOP00000053086 |
| Ensembl nucleotide ID | ENSRNOG00000037225 |
| Gene name | Thymidylate synthase |
| Gene symbol | Tyms |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. |
| Sequence | MLVEGSELQS GAQQPRTEAP QHGELQYLRQ VEHIMRCGFK KEDRTGTGTL SVFGMQARYS 60 LRDEFPLLTT KRVFWKGVLE ELLWFIKGST NAKELSSKGV RIWDANGSRD FLDSLGFSAR 120 QEGDLGPVYG FQWRHFGADY KDMDSDYSGQ GVDQLQKVID TIKTNPDDRR IIMCAWNPKD 180 LPLMALPPCH ALCQFYVVNG ELSCQLYQRS GDMGLGVPFN IASYALLTYM IAHITGLQPG 240 DFVHTLGDAH IYLNHIEPLK IQLQREPRPF PKLRILRKVE TIDDFKVEDF QIEGYNPHPT 300 IKMEMAV 307 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TYMS | F1MY63 | Bos taurus | Prediction | More>> | |||
| 1:1 ortholog | TYMS | A0A452DJS6 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | TYMS | 100060971 | F6TRC0 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | TYMS | 7298 | P04818 | CPO,CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Tyms | 22171 | P07607 | E14.5 | Mus musculus | Prediction | More>> | |
| 1:1 ortholog | TYMS | 740018 | G2HEY4 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | TYMS | A0A287AFN2 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | TYMS | 100347408 | G1SVL8 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Tyms | 29261 | P45352 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | tyms | 81540 | Q6P045 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0005829 | cytosol |
| GO:0005743 | mitochondrial inner membrane |
| GO:0005759 | mitochondrial matrix |
| GO:0005739 | mitochondrion |
| GO:0005730 | nucleolus |
| GO:0005634 | nucleus |
| GO:0048037 | cofactor binding |
| GO:0008144 | drug binding |
| GO:0005542 | folic acid binding |
| GO:0042802 | identical protein binding |
| GO:0003729 | mRNA binding |
| GO:0000166 | nucleotide binding |
| GO:1990825 | sequence-specific mRNA binding |
| GO:0004799 | thymidylate synthase activity |
| GO:0000900 | translation repressor activity, mRNA regulatory element binding |
| GO:0007568 | aging |
| GO:0051216 | cartilage development |
| GO:0007623 | circadian rhythm |
| GO:0048589 | developmental growth |
| GO:0006231 | dTMP biosynthetic process |
| GO:0006235 | dTTP biosynthetic process |
| GO:0046078 | dUMP metabolic process |
| GO:0060574 | intestinal epithelial cell maturation |
| GO:0097421 | liver regeneration |
| GO:0032259 | methylation |
| GO:0019048 | modulation by virus of host process |
| GO:0017148 | negative regulation of translation |
| GO:0006206 | pyrimidine nucleobase metabolic process |
| GO:0006417 | regulation of translation |
| GO:0034097 | response to cytokine |
| GO:0042493 | response to drug |
| GO:0045471 | response to ethanol |
| GO:0051593 | response to folic acid |
| GO:0051384 | response to glucocorticoid |
| GO:0014070 | response to organic cyclic compound |
| GO:0046683 | response to organophosphorus |
| GO:0032570 | response to progesterone |
| GO:0009636 | response to toxic substance |
| GO:0033189 | response to vitamin A |
| GO:0035999 | tetrahydrofolate interconversion |
| GO:0046653 | tetrahydrofolate metabolic process |
| GO:0019860 | uracil metabolic process |
| Keyword ID | Keyword Term |
|---|---|
| KW-0002 | 3D-structure |
| KW-0963 | Cytoplasm |
| KW-1017 | Isopeptide bond |
| KW-0472 | Membrane |
| KW-0489 | Methyltransferase |
| KW-0496 | Mitochondrion |
| KW-0999 | Mitochondrion inner membrane |
| KW-0545 | Nucleotide biosynthesis |
| KW-0539 | Nucleus |
| KW-0597 | Phosphoprotein |
| KW-1185 | Reference proteome |
| KW-0808 | Transferase |
| KW-0832 | Ubl conjugation |
| PROSITE ID | PROSITE Term |
|---|---|
| PS00091 | THYMIDYLATE_SYNTHASE |
| Pfam ID | Pfam Term |
|---|---|
| PF00303 | Thymidylat_synt |