Gene: tyms

Basic information

Tag Content
Uniprot ID Q6P045
Entrez ID 81540
Genbank protein ID AAH65845.1
Genbank nucleotide ID NM_131760.2
Ensembl protein ID ENSDARP00000047068
Ensembl nucleotide ID ENSDARG00000042894
Gene name Thymidylate synthase
Gene symbol tyms
Organism Danio rerio
NCBI taxa ID 7955
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MPDTAVEVTN GHCVNGESKK ETNGGKKEFS LFCDERGYLS LVEFILQNGA KKGDRTGTGV 60
ISVFGTQARY SLRDQFPLLT TKRVFWKGIL EELLWFIKGS TNAKDLSEKG VRIWDANGSR 120
EFLDKNGFTD REEGDLGPVY GFQWRHFGAE YKDMHTDYSG EGVDQLQKVI DTIKSNPEDR 180
RIIMCAWNPK DLPLMALPPC HALCQFYVSN GELSCQLYQR SGDIGLGVPF NIASYALLTY 240
MIAHITGLKP GDFVHTLGDA HIYTNHIEPL KEQIQREPRP FPKLRIKRKV EQINDFCAED 300
FEIYDYNPHP TIKMQMAV 318

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologTYMSF1MY63Bos taurusPredictionMore>>
1:1 orthologTYMSA0A452DJS6Capra hircusPredictionMore>>
1:1 orthologTYMS100060971F6TRC0Equus caballusPredictionMore>>
1:1 orthologTYMS7298P04818CPO,CL/PHomo sapiensPublicationMore>>
1:1 orthologTyms22171P07607E14.5Mus musculusPredictionMore>>
1:1 orthologTYMS740018G2HEY4Pan troglodytesPredictionMore>>
1:1 orthologTYMSA0A287AFN2Sus scrofaPredictionMore>>
1:1 orthologTYMS100347408G1SVL8Oryctolagus cuniculusPredictionMore>>
1:1 orthologTyms29261P45352Rattus norvegicusPredictionMore>>
1:1 orthologtyms81540Q6P045Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005829 cytosol
GO:0005739 mitochondrion
GO:0042083 5,10-methylenetetrahydrofolate-dependent methyltransferase activity
GO:0004799 thymidylate synthase activity
GO:0006231 dTMP biosynthetic process
GO:0001654 eye development
GO:0032259 methylation
GO:0060041 retina development in camera-type eye

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0489 Methyltransferase
KW-0545 Nucleotide biosynthesis
KW-1267 Proteomics identification
KW-1185 Reference proteome
KW-0808 Transferase

Interpro

InterPro ID InterPro Term
IPR023451 Thymidate_synth/dCMP_Mease
IPR036926 Thymidate_synth/dCMP_Mease_sf
IPR000398 Thymidylate_synthase
IPR020940 Thymidylate_synthase_AS

PROSITE

PROSITE ID PROSITE Term
PS00091 THYMIDYLATE_SYNTHASE

Pfam

Pfam ID Pfam Term
PF00303 Thymidylat_synt