| Tag | Content |
|---|---|
| Uniprot ID | G3V7N1 |
| Entrez ID | 114106 |
| Genbank protein ID | EDL92648.1 |
| Genbank nucleotide ID | NM_053648.3 |
| Ensembl protein ID | ENSRNOP00000016880 |
| Ensembl nucleotide ID | ENSRNOG00000012027 |
| Gene name | Beta,beta-carotene 15,15'-dioxygenase |
| Gene symbol | Bco1 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MEIIFGRNKK EQLEPLRATV TGSIPAWLQG TLLRNGPGMH TVGDSKYNHW FDGLALLHSF 60 SIRDGEVFYR SKYLQSDTYN ANIEANRIVV SEFGTMAYPD PCKNIFSKAF SYLSHTIPDF 120 TDNCLINIMK CGEDFYATTE TNYIRKIDPQ TLETLEKVDY RKYVAVNLAT SHPHYDEAGN 180 VLNMGTSIAD KGRTKYVMFK IPATAPGSKK KGKNPLKHSE VFCSIPSRSL LSPSYYHSFG 240 VTENYVVFLE QPFKLDILKM ATAYMRGVSW ASCMTFCKED KTYIHIIDQK TRKPVPTKFY 300 TDPMVVFHHV NAYEEDGCVL FDVIAYEDNS LYQLFYLANL NKDFEEKSRL TSVPTLRRFA 360 VPLHVDKDAE VGSNLVKVSS TTATALKEKD DHVYCQPEVL YEGLELPRIN YAHNGKPYRY 420 IFAAEVQWSP VPTKILKYDV LTKSSLKWSE ESCWPAEPLF VPTPGAKDED DGVILSAIIS 480 TDPQKLPFLL ILDAKSFTEL ARASVDVDMH LDLHGLFIPD AGWNAVKQTP AKTQEDENSD 540 HPTGLTAPGL GHGENDFTAG HGGKSL 566 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | BCO1 | 102179507 | A0A452FQT3 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | BCO1 | 53630 | Q9HAY6 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Bco1 | 63857 | Q9JJS6 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | BCO1 | 468043 | H2QBK9 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | BCO1 | A0A287BCU5 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | BCO1 | 100358087 | G1SEP0 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Bco1 | 114106 | G3V7N1 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | bco1 | 84039 | Q7ZTS0 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0003834 | beta-carotene 15,15'-monooxygenase activity |
| GO:0046872 | metal ion binding |
| GO:0004497 | monooxygenase activity |
| GO:1901810 | beta-carotene metabolic process |
| GO:0042574 | retinal metabolic process |
| InterPro ID | InterPro Term |
|---|---|
| IPR004294 | Carotenoid_Oase |
| Pfam ID | Pfam Term |
|---|---|
| PF03055 | RPE65 |