Gene: Bco1

Basic information

Tag Content
Uniprot ID Q9JJS6; Q6K1L5; Q8C6N5; Q9ERN9;
Entrez ID 63857
Genbank protein ID AAG15381.1; AAM76677.1; BAC35679.1; AAG33982.1; CAB92531.2;
Genbank nucleotide ID NM_021486.3
Ensembl protein ID ENSMUSP00000034308
Ensembl nucleotide ID ENSMUSG00000031845
Gene name Beta,beta-carotene 15,15'-dioxygenase
Gene symbol Bco1
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO
Developmental stage
Data sources Manually collected
Reference 29892071
Functional description Symmetrically cleaves beta-carotene into two molecules of retinal using a dioxygenase mechanism.
Sequence
MEIIFGQNKK EQLEPVQAKV TGSIPAWLQG TLLRNGPGMH TVGESKYNHW FDGLALLHSF 60
SIRDGEVFYR SKYLQSDTYI ANIEANRIVV SEFGTMAYPD PCKNIFSKAF SYLSHTIPDF 120
TDNCLINIMK CGEDFYATTE TNYIRKIDPQ TLETLEKVDY RKYVAVNLAT SHPHYDEAGN 180
VLNMGTSVVD KGRTKYVIFK IPATVPDSKK KGKSPVKHAE VFCSISSRSL LSPSYYHSFG 240
VTENYVVFLE QPFKLDILKM ATAYMRGVSW ASCMSFDRED KTYIHIIDQR TRKPVPTKFY 300
TDPMVVFHHV NAYEEDGCVL FDVIAYEDSS LYQLFYLANL NKDFEEKSRL TSVPTLRRFA 360
VPLHVDKDAE VGSNLVKVSS TTATALKEKD GHVYCQPEVL YEGLELPRIN YAYNGKPYRY 420
IFAAEVQWSP VPTKILKYDI LTKSSLKWSE ESCWPAEPLF VPTPGAKDED DGVILSAIVS 480
TDPQKLPFLL ILDAKSFTEL ARASVDADMH LDLHGLFIPD ADWNAVKQTP AETQEVENSD 540
HPTDPTAPEL SHSENDFTAG HGGSSL 566

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologBCO1102179507A0A452FQT3Capra hircusPredictionMore>>
1:1 orthologBCO153630Q9HAY6Homo sapiensPredictionMore>>
1:1 orthologBco163857Q9JJS6CPOMus musculusPublicationMore>>
1:1 orthologBCO1468043H2QBK9Pan troglodytesPredictionMore>>
1:1 orthologBCO1A0A287BCU5Sus scrofaPredictionMore>>
1:1 orthologBCO1100358087G1SEP0Oryctolagus cuniculusPredictionMore>>
1:1 orthologBco1114106G3V7N1Rattus norvegicusPredictionMore>>
1:1 orthologbco184039Q7ZTS0Danio rerioPredictionMore>>

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0003834 beta-carotene 15,15'-monooxygenase activityISO
GO:0003834 beta-carotene 15,15'-monooxygenase activityISS
GO:0003834 beta-carotene 15,15'-monooxygenase activityIDA
GO:0003834 beta-carotene 15,15'-monooxygenase activityIBA
GO:0004744 retinal isomerase activityIBA
GO:0010436 carotenoid dioxygenase activityIBA
GO:0046872 metal ion bindingIEA

GO:Biological Process

GO ID GO Term Evidence
GO:0001523 retinoid metabolic processISO
GO:0001523 retinoid metabolic processIDA
GO:0016121 carotene catabolic processIBA
GO:0042572 retinol metabolic processIEA
GO:0042574 retinal metabolic processIBA
GO:0042574 retinal metabolic processIGI
GO:0055114 oxidation-reduction processIEA
GO:1901810 beta-carotene metabolic processIMP

GO:Cellular Component

GO ID GO Term Evidence

Reactome Pathway

Reactome ID Reactome Term Evidence
R-MMU-1430728 MetabolismIEA
R-MMU-162582 Signal TransductionIEA
R-MMU-196854 Metabolism of vitamins and cofactorsIEA
R-MMU-2187338 Visual phototransductionIEA
R-MMU-372790 Signaling by GPCRIEA
R-MMU-388396 GPCR downstream signallingIEA
R-MMU-418594 G alpha (i) signalling eventsIEA
R-MMU-6806667 Metabolism of fat-soluble vitaminsIEA
R-MMU-975634 Retinoid metabolism and transportIEA

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0223 Dioxygenase
KW-0408 Iron
KW-0479 Metal-binding
KW-0560 Oxidoreductase
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR004294 Carotenoid_Oase

PROSITE

PROSITE ID PROSITE Term

Pfam

Pfam ID Pfam Term
PF03055 RPE65

Protein-miRNA interaction