Gene: bco1

Basic information

Tag Content
Uniprot ID Q7ZTS0
Entrez ID 84039
Genbank protein ID AAH49331.1
Genbank nucleotide ID NM_001328495.1
Ensembl protein ID ENSDARP00000137596
Ensembl nucleotide ID ENSDARG00000104256
Gene name Beta-carotene 15,15'-monooxygenase 1
Gene symbol bco1
Organism Danio rerio
NCBI taxa ID 7955
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MQYDYGKNKE EHPEPIKTEV KGSIPEWVQG TLIRNGPGMF SVGETTYNHW FDGMALLHSF 60
AINKGEVTYR SRYLRGDTYN SNMQANRIVV SEMGTMAYPD PCKNIFSKVI TFLSHTIPDF 120
TDNCGNNIIK YGNDFHATSE TNYIRKIDPV TLETQEKIDY LKYLPVSIVA SHTHYDKEGN 180
SYSMGTCIAE KGKTKYMLFK VPGESRPDGS PPLKSAEAVC TLPCRSLLTP SYYHSFGMTD 240
NYFIFIEQPL KLDILKMATA YLRRVSWASC MKFHPEDSTL IHLIDRNTKK EVATKFYTDA 300
MTVYHQVNAF EDDGHVVFDV IAYDDNNLYE FFYLNKLKET MGATNLYCKP KFTRFVFPLS 360
DQGETGENLV KLKYTTASAV KEKDGKIMCQ GEVLCEGVEL PRINYNFNGK KYRYSYMCCV 420
DESPVATRIV KFDADTKQQI EWKGDDGFAS EPVFIPRPGA VDEDDGVVLT VIINNKPLQG 480
GFLLVLDAKS FKEIARACLD VEIHMDMHGY FIPGSS 516

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologBCO1102179507A0A452FQT3Capra hircusPredictionMore>>
1:1 orthologBCO153630Q9HAY6Homo sapiensPredictionMore>>
1:1 orthologBco163857Q9JJS6CPOMus musculusPublicationMore>>
1:1 orthologBCO1468043H2QBK9Pan troglodytesPredictionMore>>
1:1 orthologBCO1A0A287BCU5Sus scrofaPredictionMore>>
1:1 orthologBCO1100358087G1SEP0Oryctolagus cuniculusPredictionMore>>
1:1 orthologBco1114106G3V7N1Rattus norvegicusPredictionMore>>
1:1 orthologbco184039Q7ZTS0Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0003834 beta-carotene 15,15'-monooxygenase activity
GO:0010436 carotenoid dioxygenase activity
GO:0008198 ferrous iron binding
GO:0004497 monooxygenase activity
GO:0016121 carotene catabolic process
GO:0001754 eye photoreceptor cell differentiation
GO:0030902 hindbrain development
GO:0042574 retinal metabolic process

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0408 Iron
KW-0479 Metal-binding
KW-0503 Monooxygenase
KW-0560 Oxidoreductase
KW-1267 Proteomics identification
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR004294 Carotenoid_Oase

PROSITE

PROSITE ID PROSITE Term

Pfam

Pfam ID Pfam Term
PF03055 RPE65