Gene: BCO1

Basic information

Tag Content
Uniprot ID H2QBK9; A0A2J8LEG3;
Entrez ID 468043
Genbank protein ID
Genbank nucleotide ID XM_016930229.1
Ensembl protein ID ENSPTRP00000014319
Ensembl nucleotide ID ENSPTRG00000008389
Gene name Beta-carotene oxygenase 1
Gene symbol BCO1
Organism Pan troglodytes
NCBI taxa ID 9598
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MDIIFGRNRK EQQEPVRAKV TGKIPAWLQG TLLRNGPGMH TVGESRYNHW FDGLALLHSF 60
TIRDGEVYYR SKYLRSDTYN ANIEANRIVV SEFGTMAYPD PCKNIFSKAF SYLSHTIPDF 120
TDNCLINIMK CGEDFYATSE TNYIRKINPQ TLETLEKVDY RKYVAVNLAT SHPHYDEAGN 180
VLNMGTSIVE KGKTKYVIFK IPATVPEGKK QGKSPWKHTE VFCSIPSRSL LSPSYYHSFG 240
VTKNYVIFLE QPFRLDILKM ATAYIRRMSW ASCLAFHREE KTYIHIIDQK TRQPVQTKFY 300
TDAMVVFHHV NAYEEDGCIV FDVIAYEDNS LYQLFYLANL NQDFKENSRL TSVPTLRRFA 360
VPLHVDKNAE VGSNLIKVAS TTATALKEED GQVYCQPEFL YEGLELPRVN YAHNGKQYRY 420
VFAAGVQWSP IPTKIIKYDI LTKSSLKWRE DDCWPAEPLF VPAPGAKDED DGVILSAIVS 480
TDPQKLPFLL ILDAKSFTEL ARASVDVDMH MDLHGLFITD MDWDTKKQAA SEEQRDRVSD 540
CHGAPLT 547

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologBCO1102179507A0A452FQT3Capra hircusPredictionMore>>
1:1 orthologBCO153630Q9HAY6Homo sapiensPredictionMore>>
1:1 orthologBco163857Q9JJS6CPOMus musculusPublicationMore>>
1:1 orthologBCO1468043H2QBK9Pan troglodytesPredictionMore>>
1:1 orthologBCO1A0A287BCU5Sus scrofaPredictionMore>>
1:1 orthologBCO1100358087G1SEP0Oryctolagus cuniculusPredictionMore>>
1:1 orthologBco1114106G3V7N1Rattus norvegicusPredictionMore>>
1:1 orthologbco184039Q7ZTS0Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0003834 beta-carotene 15,15'-monooxygenase activity
GO:0010436 carotenoid dioxygenase activity
GO:0046872 metal ion binding
GO:0004744 retinal isomerase activity
GO:1901810 beta-carotene metabolic process
GO:0016121 carotene catabolic process
GO:0042574 retinal metabolic process

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0408 Iron
KW-0479 Metal-binding
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR004294 Carotenoid_Oase

PROSITE

PROSITE ID PROSITE Term

Pfam

Pfam ID Pfam Term
PF03055 RPE65