| Tag | Content |
|---|---|
| Uniprot ID | P07995; A0JN81; |
| Entrez ID | 281867 |
| Genbank protein ID | AAA97415.1; AAI26557.1; AAB60627.1; |
| Genbank nucleotide ID | NM_174363.2; XM_005205620.3; |
| Ensembl protein ID | ENSBTAP00000056958 |
| Ensembl nucleotide ID | ENSBTAG00000048508 |
| Gene name | Inhibin beta A chain |
| Gene symbol | INHBA |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. |
| Sequence | MPLLWLRGFL LASCWIIVRS SPTPGSEGHS AAPDCPSCAL ATLPKDVPNS QPEMVEAVKK 60 HILNMLHLKK RPDVTQPVPK AALLNAIRKL HVGKVGENGY VEIEDDIGRR AEMNELMEQT 120 SEIITFAESG TARKTLHFEI SKEGSDLSVV ERAEIWLFLK VPKANRTRSK VTIRLFQQQK 180 HLQGSLDAGE EAEEVGLKGE KSEMLISEKV VDARKSTWHI FPVSSCIQRL LDQGKSSLDI 240 RIACEQCQET GASLVLLGKK KKKEEEGEGK KRDGEGGAGG DEEKEQSHRP FLMLQARQSE 300 DHPHRRRRRG LECDGKVNIC CKKQFFVSFK DIGWNDWIIA PSGYHANYCE GECPSHIAGT 360 SGSSLSFHST VINHYRMRGH SPFANLKSCC VPTKLRPMSM LYYDDGQNII KKDIQNMIVE 420 ECGCS 425 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | INHBA | 281867 | P07995 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | INHBA | 483245 | E2QW13 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | INHBA | 100860960 | F8SXW5 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | INHBA | 3624 | P08476 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Inhba | 16323 | Q04998 | CPO | E12.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | INHBA | 463371 | H2QUH0 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | INHBA | 397093 | P03970 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Inhba | 29200 | P18331 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | inhbaa | 30072 | Q8QGE3 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0043509 | activin A complex |
| GO:0005576 | extracellular region |
| GO:0005615 | extracellular space |
| GO:0043512 | inhibin A complex |
| GO:0048471 | perinuclear region of cytoplasm |
| GO:0005125 | cytokine activity |
| GO:0008083 | growth factor activity |
| GO:0005179 | hormone activity |
| GO:0042802 | identical protein binding |
| GO:0017046 | peptide hormone binding |
| GO:0070699 | type II activin receptor binding |
| GO:0032924 | activin receptor signaling pathway |
| GO:0007050 | cell cycle arrest |
| GO:0035987 | endodermal cell differentiation |
| GO:0097191 | extrinsic apoptotic signaling pathway |
| GO:0061029 | eyelid development in camera-type eye |
| GO:0000082 | G1/S transition of mitotic cell cycle |
| GO:0097154 | GABAergic neuron differentiation |
| GO:0001942 | hair follicle development |
| GO:0002244 | hematopoietic progenitor cell differentiation |
| GO:0042541 | hemoglobin biosynthetic process |
| GO:0008584 | male gonad development |
| GO:0048333 | mesodermal cell differentiation |
| GO:0045786 | negative regulation of cell cycle |
| GO:0030308 | negative regulation of cell growth |
| GO:0008285 | negative regulation of cell population proliferation |
| GO:0051799 | negative regulation of hair follicle development |
| GO:0042476 | odontogenesis |
| GO:0001541 | ovarian follicle development |
| GO:0045648 | positive regulation of erythrocyte differentiation |
| GO:2001241 | positive regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| GO:0060279 | positive regulation of ovulation |
| GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0045893 | positive regulation of transcription, DNA-templated |
| GO:0042701 | progesterone secretion |
| GO:0046880 | regulation of follicle-stimulating hormone secretion |
| GO:0006357 | regulation of transcription by RNA polymerase II |
| GO:0042493 | response to drug |
| GO:0060021 | roof of mouth development |
| GO:0060395 | SMAD protein signal transduction |
| GO:0021773 | striatal medium spiny neuron differentiation |