| Tag | Content |
|---|---|
| Uniprot ID | P18331 |
| Entrez ID | 29200 |
| Genbank protein ID | AAA41436.1 |
| Genbank nucleotide ID | XM_008771714.2; XM_008771712.2; XM_008771713.2; XM_006254001.3; XM_008771715.2; XM_008771716.2; NM_017128.2; |
| Ensembl protein ID | ENSRNOP00000019272 |
| Ensembl nucleotide ID | ENSRNOG00000014320 |
| Gene name | Inhibin beta A chain |
| Gene symbol | Inhba |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. |
| Sequence | MPLLWLRGFL LASCWIIVRS SPTPGSEGHG AAPDCPSCAL ATLPKDGPNS QPEMVEAVKK 60 HILNMLHLKK RPDVTQPVPK AALLNAIRKL HVGKVGENGY VEIEDDIGRR AEMNELMEQT 120 SEIITFAESG TARKTLHFEI SKEGSDLSVV ERAEVWLFLK VPKANRTRTK VTIRLFQQQK 180 HPQGSLDMGD EAEEMGLKGE RSELLLSEKV VDARKSTWHI FPVSSSIQRL LDQGKSSLDV 240 RIACEQCQES GASLVLLGKK KKKEVDGDGK KKDGSDGGLE EEKEQSHRPF LMLQARQSED 300 HPHRRRRRGL ECDGKVNICC KKQFFVSFKD IGWNDWIIAP SGYHANYCEG ECPSHIAGTS 360 GSSLSFHSTV INHYRMRGHS PFANLKSCCV PTKLRPMSML YYDDGQNIIK KDIQNMIVEE 420 CGCS 424 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | INHBA | 281867 | P07995 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | INHBA | 483245 | E2QW13 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | INHBA | 100860960 | F8SXW5 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | INHBA | 3624 | P08476 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Inhba | 16323 | Q04998 | CPO | E12.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | INHBA | 463371 | H2QUH0 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | INHBA | 397093 | P03970 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Inhba | 29200 | P18331 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | inhbaa | 30072 | Q8QGE3 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0043509 | activin A complex |
| GO:0005576 | extracellular region |
| GO:0005615 | extracellular space |
| GO:0043512 | inhibin A complex |
| GO:0048471 | perinuclear region of cytoplasm |
| GO:0005125 | cytokine activity |
| GO:0008083 | growth factor activity |
| GO:0005179 | hormone activity |
| GO:0042802 | identical protein binding |
| GO:0034711 | inhibin binding |
| GO:0017046 | peptide hormone binding |
| GO:0044877 | protein-containing complex binding |
| GO:0005102 | signaling receptor binding |
| GO:0070699 | type II activin receptor binding |
| GO:0032924 | activin receptor signaling pathway |
| GO:0007050 | cell cycle arrest |
| GO:0071397 | cellular response to cholesterol |
| GO:0071372 | cellular response to follicle-stimulating hormone stimulus |
| GO:0035987 | endodermal cell differentiation |
| GO:0097191 | extrinsic apoptotic signaling pathway |
| GO:0061029 | eyelid development in camera-type eye |
| GO:0000082 | G1/S transition of mitotic cell cycle |
| GO:0097154 | GABAergic neuron differentiation |
| GO:0001942 | hair follicle development |
| GO:0002244 | hematopoietic progenitor cell differentiation |
| GO:0042541 | hemoglobin biosynthetic process |
| GO:0008584 | male gonad development |
| GO:0001707 | mesoderm formation |
| GO:0048333 | mesodermal cell differentiation |
| GO:0045786 | negative regulation of cell cycle |
| GO:0030308 | negative regulation of cell growth |
| GO:0008285 | negative regulation of cell population proliferation |
| GO:0051799 | negative regulation of hair follicle development |
| GO:0042476 | odontogenesis |
| GO:0001541 | ovarian follicle development |
| GO:0032270 | positive regulation of cellular protein metabolic process |
| GO:0045648 | positive regulation of erythrocyte differentiation |
| GO:2001241 | positive regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| GO:0010628 | positive regulation of gene expression |
| GO:0060279 | positive regulation of ovulation |
| GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0045893 | positive regulation of transcription, DNA-templated |
| GO:0042701 | progesterone secretion |
| GO:0046880 | regulation of follicle-stimulating hormone secretion |
| GO:0006357 | regulation of transcription by RNA polymerase II |
| GO:0042493 | response to drug |
| GO:0060021 | roof of mouth development |
| GO:0060395 | SMAD protein signal transduction |
| GO:0021773 | striatal medium spiny neuron differentiation |