| Tag | Content |
|---|---|
| Uniprot ID | Q04998 |
| Entrez ID | 16323 |
| Genbank protein ID | CAA49325.1; AAH53527.1; |
| Genbank nucleotide ID | XM_006516559.2; XM_011244286.1; XM_006516558.2; XM_011244285.2; NM_008380.2; |
| Ensembl protein ID | ENSMUSP00000047894; ENSMUSP00000132085; |
| Ensembl nucleotide ID | ENSMUSG00000041324 |
| Gene name | Inhibin beta A chain |
| Gene symbol | Inhba |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | E12.5 |
| Data sources | Manually collected |
| Reference | 7885473 |
| Functional description | Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. |
| Sequence | MPLLWLRGFL LASCWIIVRS SPTPGSEGHG SAPDCPSCAL ATLPKDGPNS QPEMVEAVKK 60 HILNMLHLKK RPDVTQPVPK AALLNAIRKL HVGKVGENGY VEIEDDIGRR AEMNELMEQT 120 SEIITFAESG TARKTLHFEI SKEGSDLSVV ERAEVWLFLK VPKANRTRTK VTIRLFQQQK 180 HPQGSLDTGD EAEEMGLKGE RSELLLSEKV VDARKSTWHI FPVSSSIQRL LDQGKSSLDV 240 RIACEQCQES GASLVLLGKK KKKEVDGDGK KKDGSDGGLE EEKEQSHRPF LMLQARQSED 300 HPHRRRRRGL ECDGKVNICC KKQFFVSFKD IGWNDWIIAP SGYHANYCEG ECPSHIAGTS 360 GSSLSFHSTV INHYRMRGHS PFANLKSCCV PTKLRPMSML YYDDGQNIIK KDIQNMIVEE 420 CGCS 424 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | INHBA | 281867 | P07995 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | INHBA | 483245 | E2QW13 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | INHBA | 100860960 | F8SXW5 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | INHBA | 3624 | P08476 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Inhba | 16323 | Q04998 | CPO | E12.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | INHBA | 463371 | H2QUH0 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | INHBA | 397093 | P03970 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Inhba | 29200 | P18331 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | inhbaa | 30072 | Q8QGE3 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005102 | signaling receptor binding | IPI |
| GO:0005125 | cytokine activity | ISS |
| GO:0005125 | cytokine activity | ISO |
| GO:0005125 | cytokine activity | IBA |
| GO:0005179 | hormone activity | IEA |
| GO:0008083 | growth factor activity | IEA |
| GO:0017046 | peptide hormone binding | ISO |
| GO:0034711 | inhibin binding | ISO |
| GO:0042802 | identical protein binding | ISO |
| GO:0044877 | protein-containing complex binding | ISO |
| GO:0070699 | type II activin receptor binding | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | ISS |
| GO:0000082 | G1/S transition of mitotic cell cycle | ISO |
| GO:0001541 | ovarian follicle development | ISS |
| GO:0001541 | ovarian follicle development | ISO |
| GO:0001707 | mesoderm formation | IDA |
| GO:0001942 | hair follicle development | ISS |
| GO:0001942 | hair follicle development | ISO |
| GO:0002244 | hematopoietic progenitor cell differentiation | ISO |
| GO:0002244 | hematopoietic progenitor cell differentiation | IDA |
| GO:0006357 | regulation of transcription by RNA polymerase II | ISS |
| GO:0006357 | regulation of transcription by RNA polymerase II | ISO |
| GO:0007050 | cell cycle arrest | ISS |
| GO:0007050 | cell cycle arrest | ISO |
| GO:0008285 | negative regulation of cell population proliferation | ISS |
| GO:0008285 | negative regulation of cell population proliferation | ISO |
| GO:0008584 | male gonad development | ISS |
| GO:0008584 | male gonad development | ISO |
| GO:0010628 | positive regulation of gene expression | ISO |
| GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation | ISO |
| GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation | IBA |
| GO:0021773 | striatal medium spiny neuron differentiation | ISO |
| GO:0030308 | negative regulation of cell growth | ISS |
| GO:0030308 | negative regulation of cell growth | ISO |
| GO:0032270 | positive regulation of cellular protein metabolic process | ISO |
| GO:0032924 | activin receptor signaling pathway | ISS |
| GO:0032924 | activin receptor signaling pathway | ISO |
| GO:0035987 | endodermal cell differentiation | ISO |
| GO:0042476 | odontogenesis | ISS |
| GO:0042476 | odontogenesis | ISO |
| GO:0042493 | response to drug | ISS |
| GO:0042493 | response to drug | ISO |
| GO:0042541 | hemoglobin biosynthetic process | ISS |
| GO:0042541 | hemoglobin biosynthetic process | ISO |
| GO:0042701 | progesterone secretion | ISS |
| GO:0042701 | progesterone secretion | ISO |
| GO:0045648 | positive regulation of erythrocyte differentiation | ISS |
| GO:0045648 | positive regulation of erythrocyte differentiation | ISO |
| GO:0045786 | negative regulation of cell cycle | ISS |
| GO:0045786 | negative regulation of cell cycle | ISO |
| GO:0045893 | positive regulation of transcription, DNA-templated | ISO |
| GO:0045893 | positive regulation of transcription, DNA-templated | IGI |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | ISO |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IDA |
| GO:0046880 | regulation of follicle-stimulating hormone secretion | ISS |
| GO:0046880 | regulation of follicle-stimulating hormone secretion | ISO |
| GO:0048333 | mesodermal cell differentiation | IDA |
| GO:0051799 | negative regulation of hair follicle development | ISO |
| GO:0060021 | roof of mouth development | ISS |
| GO:0060021 | roof of mouth development | ISO |
| GO:0060279 | positive regulation of ovulation | IMP |
| GO:0060395 | SMAD protein signal transduction | IBA |
| GO:0061029 | eyelid development in camera-type eye | IGI |
| GO:0071372 | cellular response to follicle-stimulating hormone stimulus | ISO |
| GO:0071397 | cellular response to cholesterol | ISO |
| GO:0097154 | GABAergic neuron differentiation | ISO |
| GO:0097191 | extrinsic apoptotic signaling pathway | ISO |
| GO:2001241 | positive regulation of extrinsic apoptotic signaling pathway in absence of ligand | ISS |
| GO:2001241 | positive regulation of extrinsic apoptotic signaling pathway in absence of ligand | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005576 | extracellular region | ISS |
| GO:0005576 | extracellular region | ISO |
| GO:0005576 | extracellular region | TAS |
| GO:0005615 | extracellular space | ISO |
| GO:0005615 | extracellular space | IBA |
| GO:0005615 | extracellular space | HDA |
| GO:0043509 | activin A complex | ISS |
| GO:0043509 | activin A complex | ISO |
| GO:0043512 | inhibin A complex | ISS |
| GO:0043512 | inhibin A complex | ISO |
| GO:0048471 | perinuclear region of cytoplasm | IDA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-1502540 | Signaling by Activin | IEA |
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-209822 | Glycoprotein hormones | IEA |
| R-MMU-209952 | Peptide hormone biosynthesis | IEA |
| R-MMU-2473224 | Antagonism of Activin by Follistatin | IEA |
| R-MMU-2980736 | Peptide hormone metabolism | IEA |
| R-MMU-392499 | Metabolism of proteins | IEA |
| R-MMU-9006936 | Signaling by TGF-beta family members | IEA |