| Tag | Content |
|---|---|
| Uniprot ID | P0CF24 |
| Entrez ID | 500037 |
| Genbank protein ID | |
| Genbank nucleotide ID | NM_001271104.1 |
| Ensembl protein ID | ENSRNOP00000069190 |
| Ensembl nucleotide ID | ENSRNOG00000054508 |
| Gene name | Forkhead box protein P2 |
| Gene symbol | Foxp2 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays a role in synapse formation by regulating SRPX2 levels. |
| Sequence | MMQESATETI SNSSMNQNGM STLSSQLDAG SRDGRSSGDT SSEVSTVELL HLQQQQALQA 60 ARQLLLQQQT SGLKSPKSSD KQRPLQVPVS VAMMTPQVIT PQQMQQILQQ QVLSPQQLQA 120 LLQQQQAVML QQQQLQEFYK KQQEQLHLQL LQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ 180 QQQQQQQHPG KQAKEQQQQQ QQQQLAAQQL VFQQQLLQMQ QLQQQQHLLS LQCQGLISIP 240 PGQAALPVQS LPQAGLSPAE IQQLWKEVTG VHSQEDNGIK HGGLDLTTNN SSSTTSSTTS 300 KASPPITHHS IVNGQSSVLN ARRDSSSHEE TGASHTLYGH GVCKWPGCES ICEDFGQFLK 360 HLNNEHALDD RSTAQCRVQM QVVQQLEIQL SKERERLQAM MTHLHMRPSE PKPSPKPLNL 420 VSSVTMSKNM LETSPQSLPQ TPTTPTAPVT PITQGPSVIT PASVPNVGAI RRRHSDKYNI 480 PMSSEIAPNY EFYKNADVRP PFTYATLIRQ AIMESSDRQL TLNEIYSWFT RTFAYFRRNA 540 ATWKNAVRHN LSLHKCFVRV ENVKGAVWTV DEVEYQKRRS QKITGSPTLV KNIPTSLGYG 600 AALNASLQAA LAESSLPLLS NPGLINNASS GLLQAVHEDL NGSLDHIDSN GNSSPGCSPQ 660 PHIHSIHVKE EPVIAEDEDC PMSLVTTANH SPELEDDREI EEEPLSEDLE |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | FOXP2 | A0A452FUL3 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | FOXP2 | 93986 | O15409 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Foxp2 | 114142 | P58463 | E14.5 | Mus musculus | Prediction | More>> | |
| 1:1 ortholog | FOXP2 | 449627 | Q8MJA0 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | FOXP2 | A0A5G2QN29 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Foxp2 | 500037 | P0CF24 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | foxp2 | H0WFE7 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005634 | nucleus |
| GO:0050681 | androgen receptor binding |
| GO:0003677 | DNA binding |
| GO:0003700 | DNA-binding transcription factor activity |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| GO:0042802 | identical protein binding |
| GO:0046872 | metal ion binding |
| GO:0046982 | protein heterodimerization activity |
| GO:0042803 | protein homodimerization activity |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0043565 | sequence-specific DNA binding |
| GO:0043010 | camera-type eye development |
| GO:0021757 | caudate nucleus development |
| GO:0021549 | cerebellum development |
| GO:0021987 | cerebral cortex development |
| GO:0030900 | forebrain development |
| GO:0098582 | innate vocalization behavior |
| GO:0048286 | lung alveolus development |
| GO:0030324 | lung development |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0045892 | negative regulation of transcription, DNA-templated |
| GO:0050679 | positive regulation of epithelial cell proliferation |
| GO:0060501 | positive regulation of epithelial cell proliferation involved in lung morphogenesis |
| GO:0002053 | positive regulation of mesenchymal cell proliferation |
| GO:0009791 | post-embryonic development |
| GO:0021758 | putamen development |
| GO:0033574 | response to testosterone |
| GO:0060013 | righting reflex |
| GO:0007519 | skeletal muscle tissue development |
| GO:0048745 | smooth muscle tissue development |
| GO:0042297 | vocal learning |