| Tag | Content |
|---|---|
| Uniprot ID | P58463; Q6PD37; Q8C4F0; Q8R441; |
| Entrez ID | 114142 |
| Genbank protein ID | AAK69651.1; AAH62926.1; AAL85482.1; BAC38477.1; AAH58960.1; |
| Genbank nucleotide ID | NM_053242.4; NM_001286607.1; NM_212435.1; |
| Ensembl protein ID | ENSMUSP00000031545; ENSMUSP00000111137; ENSMUSP00000111132; |
| Ensembl nucleotide ID | ENSMUSG00000029563 |
| Gene name | Forkhead box protein P2 |
| Gene symbol | Foxp2 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | |
| Developmental stage | E14.5 |
| Data sources | Homology search |
| Reference | |
| Functional description | Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. |
| Sequence | MMQESATETI SNSSMNQNGM STLSSQLDAG SRDGRSSGDT SSEVSTVELL HLQQQQALQA 60 ARQLLLQQQT SGLKSPKSSE KQRPLQVPVS VAMMTPQVIT PQQMQQILQQ QVLSPQQLQA 120 LLQQQQAVML QQQQLQEFYK KQQEQLHLQL LQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ 180 QQQQQQQQQQ QHPGKQAKEQ QQQQQQQQLA AQQLVFQQQL LQMQQLQQQQ HLLSLQRQGL 240 ISIPPGQAAL PVQSLPQAGL SPAEIQQLWK EVTGVHSMED NGIKHGGLDL TTNNSSSTTS 300 STTSKASPPI THHSIVNGQS SVLNARRDSS SHEETGASHT LYGHGVCKWP GCESICEDFG 360 QFLKHLNNEH ALDDRSTAQC RVQMQVVQQL EIQLSKERER LQAMMTHLHM RPSEPKPSPK 420 PLNLVSSVTM SKNMLETSPQ SLPQTPTTPT APVTPITQGP SVITPASVPN VGAIRRRHSD 480 KYNIPMSSEI APNYEFYKNA DVRPPFTYAT LIRQAIMESS DRQLTLNEIY SWFTRTFAYF 540 RRNAATWKNA VRHNLSLHKC FVRVENVKGA VWTVDEVEYQ KRRSQKITGS PTLVKNIPTS 600 LGYGAALNAS LQAALAESSL PLLSNPGLIN NASSGLLQAV HEDLNGSLDH IDSNGNSSPG 660 CSPQPHIHSI HVKEEPVIAE DEDCPMSLVT TANHSPELED DREIEEEPLS EDLE 714 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | FOXP2 | A0A452FUL3 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | FOXP2 | 93986 | O15409 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Foxp2 | 114142 | P58463 | E14.5 | Mus musculus | Prediction | More>> | |
| 1:1 ortholog | FOXP2 | 449627 | Q8MJA0 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | FOXP2 | A0A5G2QN29 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Foxp2 | 500037 | P0CF24 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | foxp2 | H0WFE7 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding | IMP |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | IMP |
| GO:0003677 | DNA binding | ISS |
| GO:0003677 | DNA binding | IDA |
| GO:0003700 | DNA-binding transcription factor activity | IDA |
| GO:0005515 | protein binding | IPI |
| GO:0042802 | identical protein binding | IPI |
| GO:0042803 | protein homodimerization activity | ISS |
| GO:0046872 | metal ion binding | IEA |
| GO:0050681 | androgen receptor binding | IEA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IMP |
| GO:0002053 | positive regulation of mesenchymal cell proliferation | IGI |
| GO:0007519 | skeletal muscle tissue development | IGI |
| GO:0009791 | post-embryonic development | IMP |
| GO:0021549 | cerebellum development | IMP |
| GO:0021757 | caudate nucleus development | ISS |
| GO:0021758 | putamen development | ISS |
| GO:0021987 | cerebral cortex development | IEA |
| GO:0030324 | lung development | IGI |
| GO:0033574 | response to testosterone | IEA |
| GO:0042297 | vocal learning | IMP |
| GO:0043010 | camera-type eye development | IMP |
| GO:0045892 | negative regulation of transcription, DNA-templated | IDA |
| GO:0048286 | lung alveolus development | IMP |
| GO:0048745 | smooth muscle tissue development | IGI |
| GO:0050679 | positive regulation of epithelial cell proliferation | IGI |
| GO:0060013 | righting reflex | IMP |
| GO:0060501 | positive regulation of epithelial cell proliferation involved in lung morphogenesis | IGI |
| GO:0098582 | innate vocalization behavior | IEA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005634 | nucleus | IEA |
| Reactome ID | Reactome Term | Evidence |
|---|