| Tag | Content |
|---|---|
| Uniprot ID | Q8MJA0; Q8MHX3; |
| Entrez ID | 449627 |
| Genbank protein ID | AAN60056.1; AAN03410.1; AAN03409.1; AAL57731.1; AAL57735.1; AAN03385.1; |
| Genbank nucleotide ID | NM_001009020.3 |
| Ensembl protein ID | |
| Ensembl nucleotide ID | |
| Gene name | Forkhead box protein P2 |
| Gene symbol | FOXP2 |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels (By similarity). |
| Sequence | MMQESATETI SNSSMNQNGM STLSSQLDAG SRDGRSSGDT SSEVSTVELL HLQQQQALQA 60 ARQLLLQQQT SGLKSPKSSD KQRPLQVPVS VAMMTPQVIT PQQMQQILQQ QVLSPQQLQA 120 LLQQQQAVML QQQQLQEFYK KQQEQLHLQL LQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ 180 QQQQQQQQQQ QQHPGKQAKE QQQQQQQQQQ LAAQQLVFQQ QLLQMQQLQQ QQHLLSLQRQ 240 GLISIPPGQA ALPVQSLPQA GLSPAEIQQL WKEVTGVHSM EDNGIKHGGL DLTTNNSSST 300 TSSTTSKASP PITHHSIVNG QSSVLNARRD SSSHEETGAS HTLYGHGVCK WPGCESICED 360 FGQFLKHLNN EHALDDRSTA QCRVQMQVVQ QLEIQLSKER ERLQAMMTHL HMRPSEPKPS 420 PKPLNLVSSV TMSKNMLETS PQSLPQTPTT PTAPVTPITQ GPSVITPASV PNVGAIRRRH 480 SDKYNIPMSS EIAPNYEFYK NADVRPPFTY ATLIRQAIME SSDRQLTLNE IYSWFTRTFA 540 YFRRNAATWK NAVRHNLSLH KCFVRVENVK GAVWTVDEVE YQKRRSQKIT GSPTLVKNIP 600 TSLGYGAALN ASLQAALAES SLPLLSNPGL INNASSGLLQ AVHEDLNGSL DHIDSNGNSS 660 PGCSPQPHIH SIHVKEEPVI AEDEDCPMSL VTTANHSPEL EDDREIEEEP LSEDLE 716 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | FOXP2 | A0A452FUL3 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | FOXP2 | 93986 | O15409 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Foxp2 | 114142 | P58463 | E14.5 | Mus musculus | Prediction | More>> | |
| 1:1 ortholog | FOXP2 | 449627 | Q8MJA0 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | FOXP2 | A0A5G2QN29 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Foxp2 | 500037 | P0CF24 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | foxp2 | H0WFE7 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005634 | nucleus |
| GO:0003677 | DNA binding |
| GO:0003700 | DNA-binding transcription factor activity |
| GO:0046872 | metal ion binding |
| GO:0042803 | protein homodimerization activity |
| GO:0043565 | sequence-specific DNA binding |
| GO:0021757 | caudate nucleus development |
| GO:0021758 | putamen development |