Gene: Gad1

Basic information

Tag Content
Uniprot ID P18088
Entrez ID 24379
Genbank protein ID CAA40800.1; CAA40801.1; AAA41184.1; AAC42037.1;
Genbank nucleotide ID XM_017591455.1; NM_017007.1; XM_017591454.1;
Ensembl protein ID ENSRNOP00000072778; ENSRNOP00000000008;
Ensembl nucleotide ID ENSRNOG00000000007
Gene name Glutamate decarboxylase 1
Gene symbol Gad1
Organism Rattus norvegicus
NCBI taxa ID 10116
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Catalyzes the production of GABA.
Sequence
MASSTPSPAT SSNAGADPNT TNLRPTTYDT WCGVAHGCTR KLGLKICGFL QRTNSLEEKS 60
RLVSAFRERQ ASKNLLSCEN SDPGARFRRT ETDFSNLFAQ DLLPAKNGEE QTVQFLLEVV 120
DILLNYVRKT FDRSTKVLDF HHPHQLLEGM EGFNLELSDH PESLEQILVD CRDTLKYGVR 180
TGHPRFFNQL STGLDIIGLA GEWLTSTANT NMFTYEIAPV FVLMEQITLK KMREIIGWSN 240
KDGDGIFSPG GAISNMYSIM AARYKYFPEV KTKGMAAVPK LVLFTSEHSH YSIKKAGAAL 300
GFGTDNVILI KCNERGKIIP ADLEAKILDA KQKGFVPLYV NATAGTTVYG AFDPIQEIAD 360
ICEKYNLWLH VDAAWGGGLL MSRKHRHKLS GIERANSVTW NPHKMMGVLL QCSAILVKEK 420
GILQGCNQMC AGYLFQPDKQ YDVSYDTGDK AIQCGRHVDI FKFWLMWKAK GTVGFENQIN 480
KCLELAEYLY AKIKNREEFE MVFNGEPEHT NVCFWYIPQS LRGVPDSPER REKLHRVAPK 540
IKALMMESGT TMVGYQPQGD KANFFRMVIS NPAATQSDID FLIEEIERLG QDL 593

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologGAD1517552Q0VCA1Bos taurusPredictionMore>>
1:1 orthologGAD1J9P2A8Canis lupus familiarisPredictionMore>>
1:1 orthologGAD1A0A452F295Capra hircusPredictionMore>>
1:1 orthologGAD1100052860F6ZIC0Equus caballusPredictionMore>>
1:1 orthologGAD12571Q99259CL/PHomo sapiensPublicationMore>>
1:1 orthologGad114415P48318CPOMus musculusPublicationMore>>
1:1 orthologGAD1468557Q5IS68Pan troglodytesPredictionMore>>
1:1 orthologGAD1396928P48319Sus scrofaPredictionMore>>
1:1 orthologGAD1100344727G1T3T2Oryctolagus cuniculusPredictionMore>>
1:1 orthologGad124379P18088Rattus norvegicusPredictionMore>>
1:1 orthologgad1bF1Q5U5Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0030424 axon
GO:0043679 axon terminus
GO:0005938 cell cortex
GO:0005737 cytoplasm
GO:0060077 inhibitory synapse
GO:0044306 neuron projection terminus
GO:0048786 presynaptic active zone
GO:0045202 synapse
GO:0016595 glutamate binding
GO:0004351 glutamate decarboxylase activity
GO:0047485 protein N-terminus binding
GO:0044877 protein-containing complex binding
GO:0030170 pyridoxal phosphate binding
GO:0009449 gamma-aminobutyric acid biosynthetic process
GO:0035641 locomotory exploration behavior
GO:0042493 response to drug
GO:0035176 social behavior

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0210 Decarboxylase
KW-0456 Lyase
KW-0530 Neurotransmitter biosynthesis
KW-0597 Phosphoprotein
KW-0663 Pyridoxal phosphate
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR002129 PyrdxlP-dep_de-COase
IPR015424 PyrdxlP-dep_Trfase
IPR015421 PyrdxlP-dep_Trfase_major
IPR021115 Pyridoxal-P_BS

PROSITE

PROSITE ID PROSITE Term
PS00392 DDC_GAD_HDC_YDC

Pfam

Pfam ID Pfam Term
PF00282 Pyridoxal_deC