Gene: GAD1

Basic information

Tag Content
Uniprot ID P48319
Entrez ID 396928
Genbank protein ID BAA06636.1
Genbank nucleotide ID NM_213894.1
Ensembl protein ID ENSSSCP00015032241; ENSSSCP00070041427; ENSSSCP00070041424;
Ensembl nucleotide ID ENSSSCG00015059664; ENSSSCG00070024572;
Gene name Glutamate decarboxylase 1
Gene symbol GAD1
Organism Sus scrofa
NCBI taxa ID 9823
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Catalyzes the production of GABA.
Sequence
MASSTPSSSA TSSNAGPDPN TTNLRPTTYD TWCGVAHGCT RKLGLKICGF LQRTNSLEEK 60
SRLVSAFKER QSSKNLLSCE NSDRDGRFRR TETDFSNLFA RDLLPAKNGE EQTVQFLLEV 120
VDILLNYVRK TFDRSTKVLD FHHPHQLLEG MEGFNLELSD HPESLEQILV DCRDTLKYGV 180
RTGHPRFFNQ LSTGLDIIGL AGEWLTSTAN TNMFTYEIAP VFVLMEQITL KKMREIVGWS 240
NKDGDGIFSP GGAISNMYSI MAARYKYFPE VKTKGMAAVP KLVLFTSEHS HYSIKKAGAA 300
LGFGTDNVIL IKCNERGKII PADLEAKILE AKQKGYIPLY VNATAGTTVY GAFDPIQEIA 360
DICEKYNLWL HVDAAWGGGL LMSRKHRHKL SGIERADSVT WNPHKMMGVL LQCSAILVKE 420
KGILQGCNQM CAGYLFQPDK QYDVSYDTGD KAIQCGRHVD IFKFWLMWKA KGTVGFENQI 480
NKCLELAEYL YAKIKNREEF EMVFDGEPEH TNVCFWYIPQ SLRGVPDSPE RREKLHRVAP 540
KIKALMMESG TTMVGYQPQG DKANFFRMVI SNPAATQSDI DFLIEEIERL GQDL 594

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologGAD1517552Q0VCA1Bos taurusPredictionMore>>
1:1 orthologGAD1J9P2A8Canis lupus familiarisPredictionMore>>
1:1 orthologGAD1A0A452F295Capra hircusPredictionMore>>
1:1 orthologGAD1100052860F6ZIC0Equus caballusPredictionMore>>
1:1 orthologGAD12571Q99259CL/PHomo sapiensPublicationMore>>
1:1 orthologGad114415P48318CPOMus musculusPublicationMore>>
1:1 orthologGAD1468557Q5IS68Pan troglodytesPredictionMore>>
1:1 orthologGAD1396928P48319Sus scrofaPredictionMore>>
1:1 orthologGAD1100344727G1T3T2Oryctolagus cuniculusPredictionMore>>
1:1 orthologGad124379P18088Rattus norvegicusPredictionMore>>
1:1 orthologgad1bF1Q5U5Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0043679 axon terminus
GO:0005938 cell cortex
GO:0060077 inhibitory synapse
GO:0048786 presynaptic active zone
GO:0004351 glutamate decarboxylase activity
GO:0030170 pyridoxal phosphate binding
GO:0019752 carboxylic acid metabolic process
GO:0035641 locomotory exploration behavior
GO:0042136 neurotransmitter biosynthetic process
GO:0035176 social behavior

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0210 Decarboxylase
KW-0456 Lyase
KW-0530 Neurotransmitter biosynthesis
KW-0597 Phosphoprotein
KW-0663 Pyridoxal phosphate
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR002129 PyrdxlP-dep_de-COase
IPR015424 PyrdxlP-dep_Trfase
IPR015421 PyrdxlP-dep_Trfase_major
IPR021115 Pyridoxal-P_BS

PROSITE

PROSITE ID PROSITE Term
PS00392 DDC_GAD_HDC_YDC

Pfam

Pfam ID Pfam Term
PF00282 Pyridoxal_deC