| Tag | Content |
|---|---|
| Uniprot ID | Q28397 |
| Entrez ID | 100034195 |
| Genbank protein ID | AAB05774.1 |
| Genbank nucleotide ID | NM_001082495.2 |
| Ensembl protein ID | ENSECAP00000001652 |
| Ensembl nucleotide ID | ENSECAG00000019445 |
| Gene name | Stromelysin-1 |
| Gene symbol | MMP3 |
| Organism | Equus caballus |
| NCBI taxa ID | 9796 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase. |
| Sequence | MKNLPILLLL CVAACSAYPL DRSARDEDSN MDLLQDYLEK YYDLGKEMRQ YVRRKDSGPI 60 VKKIQEMQKF LGLKVTGKLD SDTVEVMHKS RCGVPDVGHF TTFPGMPKWS KTHLTYRIVN 120 YTQDLPRDAV DSDVEKALKI WEEVTPLTFS RIYEGEADIM ITFAVREHGD FFPFDGPGKV 180 LAHAYPPGPG MNGDAHFDDD EHWTKDASGI NFLLVAAHEL GHSLGLYHST NTEALMYPLY 240 NTLKGPARVR LSQDDVTGIQ SLYGPPPASP DSPVEPSEPE PPAPGTLAMC DPALSFDAIS 300 TLRGEILFFK DRYFWRKTFR TLVPEFHPIS SFWPSLPSGI DAAYEVTSRD SVFIFKGNKF 360 WAIRGNEEQA GYPRGIHTLG FPPTVRKIDA AIFDKEKQKT YFFVEDKYWR FDEKRQSMEP 420 GYPKQIAEDF PGIDSKLDAA FESFGFFYFF SGSSQFEFDP NAKKVTHVLK SNSWFNC 477 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | MMP3 | 403445 | Q6Y4Q5 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | MMP3 | 102170893 | A0A452FPV6 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | MMP3 | 100034195 | Q28397 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | MMP3 | 4314 | P08254 | CPO,CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Mmp3 | 17392 | Q922W6 | E12.5, E13.5, E14.5 | Mus musculus | Prediction | More>> | |
| 1:1 ortholog | MMP3 | 451511 | H2Q4N2 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | MMP3 | F1SV58 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Mmp3 | F1LPL9 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0031012 | extracellular matrix |
| GO:0004222 | metalloendopeptidase activity |
| GO:0008233 | peptidase activity |
| GO:0008270 | zinc ion binding |
| GO:0030574 | collagen catabolic process |
| GO:0030198 | extracellular matrix organization |
| GO:0010727 | negative regulation of hydrogen peroxide metabolic process |
| GO:0031334 | positive regulation of protein-containing complex assembly |
| Keyword ID | Keyword Term |
|---|---|
| KW-0002 | 3D-structure |
| KW-0106 | Calcium |
| KW-0177 | Collagen degradation |
| KW-1015 | Disulfide bond |
| KW-0272 | Extracellular matrix |
| KW-0325 | Glycoprotein |
| KW-0378 | Hydrolase |
| KW-0479 | Metal-binding |
| KW-0482 | Metalloprotease |
| KW-0645 | Protease |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0964 | Secreted |
| KW-0732 | Signal |
| KW-0862 | Zinc |
| KW-0865 | Zymogen |
| InterPro ID | InterPro Term |
|---|---|
| IPR000585 | Hemopexin-like_dom |
| IPR036375 | Hemopexin-like_dom_sf |
| IPR018487 | Hemopexin-like_repeat |
| IPR018486 | Hemopexin_CS |
| IPR033739 | M10A_MMP |
| IPR024079 | MetalloPept_cat_dom_sf |
| IPR001818 | Pept_M10_metallopeptidase |
| IPR021190 | Pept_M10A |
| IPR006026 | Peptidase_Metallo |
| IPR002477 | Peptidoglycan-bd-like |
| IPR036365 | PGBD-like_sf |