| Tag | Content |
|---|---|
| Uniprot ID | Q6Y4Q5 |
| Entrez ID | 403445 |
| Genbank protein ID | AAO63580.1 |
| Genbank nucleotide ID | NM_001002967.1 |
| Ensembl protein ID | ENSCAFP00030022012; ENSCAFP00040033135; ENSCAFP00000022195; |
| Ensembl nucleotide ID | ENSCAFG00000015063; ENSCAFG00040020536; ENSCAFG00030013617; |
| Gene name | Stromelysin-1 |
| Gene symbol | MMP3 |
| Organism | Canis lupus familiaris |
| NCBI taxa ID | 9615 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase (By similarity). |
| Sequence | MQNLPALLLF CGVVCSAYPV DRAAEDENNN MELTQQYLEN YYNLGKDVKP FVRRRNSGPV 60 VEKIREMQKF LGLEVTGKVD SDTLAMMRRP RCGVPDVGDF TTFPGMPKWR KTHLTYRIMN 120 YTPDLPRDAV DSAIEKALNV WKEVTPLTFS RTDEGEADIK ISFAVRDHGD FNPFDGPGNV 180 LGHAYPPGPG IYGDAHFDDD EQWTSDTSGT NLFLVAAHEL GHSLGLFHSA DPSALMYPVY 240 NVLADLARFH LSQDDVNGIQ SLYGGPPSDS SNDPVVPTES VPPGPGTPAA CDPTLSFDAI 300 STLRGEFLFF KDRHFWRKSL RTLEPGFYLI SSFWPSLPSG LDAAYEETSK DIVFIFKGNQ 360 FWAMRGTEVQ AGYPKGIHTL GFPPTVKKID AAVFDKEKKK TYFFVGDKYW RFDEKRQSME 420 PGFPKQIAED FPGVDSKVDA AFEAFGFYYF FNGSSQLEFD PNAKKVTHVL KSNSWLNC 478 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | MMP3 | 403445 | Q6Y4Q5 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | MMP3 | 102170893 | A0A452FPV6 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | MMP3 | 100034195 | Q28397 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | MMP3 | 4314 | P08254 | CPO,CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Mmp3 | 17392 | Q922W6 | E12.5, E13.5, E14.5 | Mus musculus | Prediction | More>> | |
| 1:1 ortholog | MMP3 | 451511 | H2Q4N2 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | MMP3 | F1SV58 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Mmp3 | F1LPL9 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0031012 | extracellular matrix |
| GO:0004222 | metalloendopeptidase activity |
| GO:0008233 | peptidase activity |
| GO:0008270 | zinc ion binding |
| GO:0030574 | collagen catabolic process |
| GO:0030198 | extracellular matrix organization |
| GO:0010727 | negative regulation of hydrogen peroxide metabolic process |
| GO:0031334 | positive regulation of protein-containing complex assembly |
| Keyword ID | Keyword Term |
|---|---|
| KW-0106 | Calcium |
| KW-0177 | Collagen degradation |
| KW-1015 | Disulfide bond |
| KW-0272 | Extracellular matrix |
| KW-0325 | Glycoprotein |
| KW-0378 | Hydrolase |
| KW-0479 | Metal-binding |
| KW-0482 | Metalloprotease |
| KW-0645 | Protease |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0964 | Secreted |
| KW-0732 | Signal |
| KW-0862 | Zinc |
| KW-0865 | Zymogen |
| InterPro ID | InterPro Term |
|---|---|
| IPR000585 | Hemopexin-like_dom |
| IPR036375 | Hemopexin-like_dom_sf |
| IPR018487 | Hemopexin-like_repeat |
| IPR018486 | Hemopexin_CS |
| IPR033739 | M10A_MMP |
| IPR024079 | MetalloPept_cat_dom_sf |
| IPR001818 | Pept_M10_metallopeptidase |
| IPR021190 | Pept_M10A |
| IPR021158 | Pept_M10A_Zn_BS |
| IPR006026 | Peptidase_Metallo |
| IPR002477 | Peptidoglycan-bd-like |
| IPR036365 | PGBD-like_sf |
| IPR036366 | PGBDSf |