| Tag | Content |
|---|---|
| Uniprot ID | Q922W6 |
| Entrez ID | 17392 |
| Genbank protein ID | AAH06725.1; AAO37583.1; |
| Genbank nucleotide ID | NM_010809.2 |
| Ensembl protein ID | ENSMUSP00000034497 |
| Ensembl nucleotide ID | ENSMUSG00000043613 |
| Gene name | Matrix metallopeptidase 3 |
| Gene symbol | Mmp3 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | |
| Developmental stage | E12.5, E13.5, E14.5 |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MKMKGLPVLL WLCVVVCSSY PLHDSARDDD AGMELLQKYL ENYYGLAKDV KQFIKKKDSS 60 LIVKKIQEMQ KFLGLEMTGK LDSNTMELMH KPRCGVPDVG GFSTFPGSPK WRKSHITYRI 120 VNYTPDLPRQ SVDSAIEKAL KVWEEVTPLT FSRISEGEAD IMISFAVGEH GDFVPFDGPG 180 TVLAHAYAPG PGINGDAHFD DDERWTEDVT GTNLFLVAAH ELGHSLGLYH SAKAEALMYP 240 VYKSSTDLSR FHLSQDDVDG IQSLYGTPTA SPDVLVVPTK SNSLEPETSP MCSSTLFFDA 300 VSTLRGEVLF FKDRHFWRKS LRTPEPEFYL ISSFWPSLPS NMDAAYEVTN RDTVFIFKGN 360 QFWAIRGHEE LAGYPKSIHT LGLPATVKKI DAAISNKEKR KTYFFVEDKY WRFDEKKQSM 420 EPGFPRKIAE DFPGVDSRVD AVFEAFGFLY FFSGSSQLEF DPNAKKVTHI LKSNSWFNC 479 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | MMP3 | 403445 | Q6Y4Q5 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | MMP3 | 102170893 | A0A452FPV6 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | MMP3 | 100034195 | Q28397 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | MMP3 | 4314 | P08254 | CPO,CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Mmp3 | 17392 | Q922W6 | E12.5, E13.5, E14.5 | Mus musculus | Prediction | More>> | |
| 1:1 ortholog | MMP3 | 451511 | H2Q4N2 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | MMP3 | F1SV58 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Mmp3 | F1LPL9 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|
| GO ID | GO Term | Evidence |
|---|
| GO ID | GO Term | Evidence |
|---|
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-1442490 | Collagen degradation | IEA |
| R-MMU-1474228 | Degradation of the extracellular matrix | IEA |
| R-MMU-1474244 | Extracellular matrix organization | IEA |
| R-MMU-1474290 | Collagen formation | IEA |
| R-MMU-1592389 | Activation of Matrix Metalloproteinases | IEA |
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-2022090 | Assembly of collagen fibrils and other multimeric structures | IEA |
| R-MMU-2179392 | EGFR Transactivation by Gastrin | IEA |
| R-MMU-372790 | Signaling by GPCR | IEA |
| R-MMU-388396 | GPCR downstream signalling | IEA |
| R-MMU-416476 | G alpha (q) signalling events | IEA |
| R-MMU-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | IEA |
| R-MMU-8939211 | ESR-mediated signaling | IEA |
| R-MMU-9006931 | Signaling by Nuclear Receptors | IEA |
| R-MMU-9009391 | Extra-nuclear estrogen signaling | IEA |
| InterPro ID | InterPro Term |
|---|---|
| IPR000585 | Hemopexin-like_dom |
| IPR036375 | Hemopexin-like_dom_sf |
| IPR018487 | Hemopexin-like_repeat |
| IPR018486 | Hemopexin_CS |
| IPR033739 | M10A_MMP |
| IPR024079 | MetalloPept_cat_dom_sf |
| IPR001818 | Pept_M10_metallopeptidase |
| IPR021190 | Pept_M10A |
| IPR021158 | Pept_M10A_Zn_BS |
| IPR006026 | Peptidase_Metallo |
| IPR002477 | Peptidoglycan-bd-like |
| IPR036365 | PGBD-like_sf |