| Tag | Content |
|---|---|
| Uniprot ID | Q5RJ97; F1QMY2; |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSDARP00000015055; ENSDARP00000070893; |
| Ensembl nucleotide ID | ENSDARG00000014013 |
| Gene name | 3-beta-hydroxysterol Delta (14)-reductase |
| Gene symbol | lbr |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MPPARFQIGD TVMGRWPGSN LYYEVKVMSF DNKTRLYTVI YKDGTELELK ESDITSVVIF 60 QTAGRSRSRS RSPGRSPGRS SARSPGRPRR SRSRSPARTP RRASSRSTEV RKEKLKEVLE 120 VRLTPVAMKH ENNSSNSKSE KKEENNTAKA APVVTEEKTE TESENQTGGR YNLRRRKDQG 180 DGKAVELEKA VESEPLLQTK APAAVKTADL EFGGRVGVLF LMFLLPVAVL VLLILCGQKD 240 ASLQSFPLEL PALQSVWDCQ VFGIVLLWLL FQAFLSLLPV GKLVEGMPLK NGKTLKYRIN 300 GFYALLLTAV AAGVAVYQEV DLSYIHAHFL QFYTSALLIA TLLSIYLFIR SRWASKDELA 360 PGGNSGYIIY DFFMGRELNP RIKSFDIKFF CEMRPGLMGW VLINFAMLLA EMKQQNLENP 420 SPAMLLVNIF QLLWVIDGLW HEEKLLTMMD IMYDGFGFML TFGDLAFVPF TFTCQAYYLV 480 NHPNELSVFW IITLIAMNGV GYYIFRKANS QKFAFRKNPS DPAVSHLKTI PTATGKSLIV 540 SGLWGFVRHP NYLGDIIMAL AWSLPCGFNN LVPYFYLIYL VTLLVHRNAR DERQCRKKYG 600 SAWEEYCKAV PYRIFPRVY 619 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | LBR | 509348 | A6QQV8 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | LBR | 490391 | E2QV27 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | LBR | 100056997 | A0A3Q2GWX9 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | LBR | 3930 | Q14739 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Lbr | 98386 | Q3U9G9 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | LBR | 457776 | H2Q178 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | LBR | M3VH35 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | LBR | 100345014 | G1SCZ4 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | A0A0G2JU83 | Rattus norvegicus | Prediction | More>> | ||||
| 1:1 ortholog | lbr | Q5RJ97 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0016021 | integral component of membrane |
| GO:0005637 | nuclear inner membrane |
| GO:0016627 | oxidoreductase activity, acting on the CH-CH group of donors |
| GO:0016628 | oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor |
| GO:0042074 | cell migration involved in gastrulation |
| GO:0006695 | cholesterol biosynthetic process |
| GO:0016126 | sterol biosynthetic process |
| Keyword ID | Keyword Term |
|---|---|
| KW-0152 | Cholesterol biosynthesis |
| KW-0153 | Cholesterol metabolism |
| KW-0963 | Cytoplasm |
| KW-0444 | Lipid biosynthesis |
| KW-0443 | Lipid metabolism |
| KW-0472 | Membrane |
| KW-0539 | Nucleus |
| KW-0560 | Oxidoreductase |
| KW-1267 | Proteomics identification |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0752 | Steroid biosynthesis |
| KW-0753 | Steroid metabolism |
| KW-0756 | Sterol biosynthesis |
| KW-1207 | Sterol metabolism |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |