| Tag | Content |
|---|---|
| Uniprot ID | Q8BH61; Q3TNF9; Q8BIP2; |
| Entrez ID | 74145 |
| Genbank protein ID | BAC29414.1; AAH40274.1; BAE38130.1; BAC33539.1; |
| Genbank nucleotide ID | NM_001166391.1; NM_028784.3; |
| Ensembl protein ID | ENSMUSP00000128316; ENSMUSP00000048667; |
| Ensembl nucleotide ID | ENSMUSG00000039109 |
| Gene name | Coagulation factor XIII A chain |
| Gene symbol | F13a1 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. |
| Sequence | MSDTPASTFG GRRAVPPNNS NAAEVDLPTE ELQGLVPRGV NLKDYLNVTA VHLFKERWDS 60 NKIDHHTDKY DNNKLIVRRG QTFYIQIDFN RPYDPRKDLF RVEYVIGRYP QENKGTYIPV 120 PVVKELQSGK WGAKVIMNED RSVRLSVQSS PECIVGKFRM YVAVWTPYGI LRTRRDPETD 180 TYILFNPWCE EDAVYLDDEK EREEYVLNDI GVIFYGDFKD IKSRSWSYGQ FEDGILDTCL 240 YVMDKAEMDL SGRGNPIKVS RVGSAMVNAK DDEGVLVGSW DNVYAYGIPP SAWTGSVDIL 300 LEYRSSETPV RYGQCWVFAG VFNTFLRCLG IPARVITNYF SAHDNDANLQ MDIFLEEDGN 360 VSSKLTKDSV WNYHCWNEAW MTRPDLPVGF GGWQAVDSTP QENSDGMYRC GPASVQAVKH 420 GHVCFQFDAP FVFAEVNSDL VYITAKQDGT HVVEAVDATH IGKLIVTKQI GGDGMQDITD 480 TYKFQEGQEE ERLALETALM YGAKKTLNTE GVVKSRSDVT MNFDVENAVL GKDFKVTITF 540 QNNSSNLYTI LAYLSGNITF YTGVSKKEFK KESFEETLDP FSSKKKEVLV RAGEYMSHLL 600 EQGFLHFFVT ARINESRDVL AKQKSIILTI PKITIKVRGA AMVGSDMVVT VEFTNPLKET 660 LQNVWIHLDG PGVMRPKRKV FREIRPNTTV QWEEVCRPWV SGHRKLIASM TSDSLRHVYG 720 ELDLQIQRRP TM 732 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | F13A1 | F1PKX3 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | F13A1 | 102169238 | A0A452FF40 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | F13A1 | 2162 | P00488 | CPO,CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | F13a1 | 74145 | Q8BH61 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | F13A1 | 462413 | H2QS92 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | F13A1 | 100153504 | K7GQL2 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | F13a1 | 60327 | G3V811 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | f13a1b | F1R1R7 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0003810 | protein-glutamine gamma-glutamyltransferase activity | ISS |
| GO:0003810 | protein-glutamine gamma-glutamyltransferase activity | ISO |
| GO:0003810 | protein-glutamine gamma-glutamyltransferase activity | IMP |
| GO:0003810 | protein-glutamine gamma-glutamyltransferase activity | IBA |
| GO:0046872 | metal ion binding | IEA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0007596 | blood coagulation | ISO |
| GO:0007596 | blood coagulation | IMP |
| GO:0018149 | peptide cross-linking | ISS |
| GO:0018149 | peptide cross-linking | ISO |
| GO:0018149 | peptide cross-linking | IMP |
| GO:0018149 | peptide cross-linking | IBA |
| GO:0072378 | blood coagulation, fibrin clot formation | ISS |
| GO:0072378 | blood coagulation, fibrin clot formation | ISO |
| GO:0072378 | blood coagulation, fibrin clot formation | IMP |
| GO:0072378 | blood coagulation, fibrin clot formation | IBA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005737 | cytoplasm | IEA |
| GO:0062023 | collagen-containing extracellular matrix | HDA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-109582 | Hemostasis | IEA |
| R-MMU-114608 | Platelet degranulation | IEA |
| R-MMU-140875 | Common Pathway of Fibrin Clot Formation | IEA |
| R-MMU-140877 | Formation of Fibrin Clot (Clotting Cascade) | IEA |
| R-MMU-76002 | Platelet activation, signaling and aggregation | IEA |
| R-MMU-76005 | Response to elevated platelet cytosolic Ca2+ | IEA |
| InterPro ID | InterPro Term |
|---|---|
| IPR034810 | Factor_XIII_A |
| IPR013783 | Ig-like_fold |
| IPR014756 | Ig_E-set |
| IPR038765 | Papain-like_cys_pep_sf |
| IPR002931 | Transglutaminase-like |
| IPR036985 | Transglutaminase-like_sf |
| IPR023608 | Transglutaminase_animal |
| IPR013808 | Transglutaminase_AS |
| IPR008958 | Transglutaminase_C |
| IPR036238 | Transglutaminase_C_sf |
| IPR001102 | Transglutaminase_N |
| PROSITE ID | PROSITE Term |
|---|---|
| PS00547 | TRANSGLUTAMINASES |