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Dataset Description
  • Dataset Name: 18477577
  • Species: Human
  • Method: Addiction array gene list
  • No. of Genes: 130
  • Publication: Hodgkinson et al. Alcohol Alcohol. (2008) Addictions Biology: Haplotype-Based Analysis for 130 Candidate Genes on a Single Array. PubMed
  • Dataset Summary: To develop a panel of markers able to extract full haplotype information for candidate genes in alcoholism, other addictions and disorders of mood and anxiety. Methods: A total of 130 genes were haplotype tagged and genotyped in 7 case/control populations and 51 reference populations using Illumina GoldenGate SNP genotyping technology, determining haplotype coverage. The 130 candidate genes were selected on the basis of their roles in functional domains important in the addictions and in the related phenotypes of anxiety and depression. The candidate genes included a limited number involved in the pharmacokinetic domain (e.g. several genes in the ADH gene cluster, and ALDH genes). The majority of the genes represent the domains of vulnerability to drug use and pharmacodynamic response. These include dopamine, serotonin, glutamine, GABA, and opioid neurotransmitter genes, signaling genes, and genes modulating stress resiliency and behavioral dyscontrol domains. There is a high degree of overlap between functional gene categories because of pleiotropic actions of molecules on behavior.

    Gene list of this dataset (130 genes)
    Page: 1 2 3 list all   
    GeneIDSymbolNameGenetic location
    4887NPY2Rneuropeptide Y receptor Y24q31
    4889NPY5Rneuropeptide Y receptor Y54q31-q32
    2908NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)5q31.3
    4915NTRK2neurotrophic tyrosine kinase, receptor, type 29q22.1
    4923NTSR1neurotensin receptor 1 (high affinity)20q13
    23620NTSR2neurotensin receptor 22p25.1
    4985OPRD1opioid receptor, delta 11p36.1-p34.3
    4986OPRK1opioid receptor, kappa 18q11.2
    4987OPRL1opiate receptor-like 120q13.33
    4988OPRM1opioid receptor, mu 16q24-q25
    5020OXToxytocin, prepro- (neurophysin I)20p13
    5173PDYNprodynorphin20pter-p12
    5179PENKproenkephalin8q23-q24
    5368PNOCprepronociceptin8p21
    5443POMCproopiomelanocortin (adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin)2p23.3
    84152PPP1R1Bprotein phosphatase 1, regulatory (inhibitor) subunit 1B (dopamine and cAMP regulated phosphoprotein, DARPP-32)17q12
    5581PRKCEprotein kinase C, epsilon2p21
    6571SLC18A2solute carrier family 18 (vesicular monoamine), member 210q25
    2030SLC29A1solute carrier family 29 (nucleoside transporters), member 16p21.2-p21.1
    140679SLC32A1solute carrier family 32 (GABA vesicular transporter), member 120q11.23
    6538SLC6A11solute carrier family 6 (neurotransmitter transporter, GABA), member 113p25.3
    6540SLC6A13solute carrier family 6 (neurotransmitter transporter, GABA), member 1312p13.3
    6530SLC6A2solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 216q12.2
    6531SLC6A3solute carrier family 6 (neurotransmitter transporter, dopamine), member 35p15.3
    6532SLC6A4solute carrier family 6 (neurotransmitter transporter, serotonin), member 417q11.1-q12
    6534SLC6A7solute carrier family 6 (neurotransmitter transporter, L-proline), member 75q31-q32
    6863TAC1tachykinin, precursor 17q21-q22
    7054THtyrosine hydroxylase11p15.5
    7166TPH1tryptophan hydroxylase 1 (tryptophan 5-monooxygenase)11p15.3-p14
    121278TPH2tryptophan hydroxylase 212q21.1
    Page: 1 2 3 list all